Leukemias, lymphomas, and other hematologic cancers:

Indications for POTELIGEO:

Treatment of adults with relapsed or refractory mycosis fungoides or Sézary syndrome after at least one prior systemic therapy.

Adult:

Premedicate with diphenydramine and acetaminophen for the 1st infusion. Infuse IV over ≥60mins. 1mg/kg on Days 1, 8, 15, and 22 of the first 28-day cycle, then on Days 1 and 15 of each subsequent cycle until disease progression or unacceptable toxicity. Dose modifications for toxicity: see full labeling.

Children:

Not established.

Warnings/Precautions:

Monitor for skin rash; permanently discontinue if SJS/TEN or life-threatening reaction (Grade 4) occurs. Monitor for infusion reactions; interrupt for any grade reaction and treat promptly; permanently discontinue for life-threatening reaction (Grade 4). Monitor for infection; treat promptly. History of autoimmune disease. Interrupt or permanently discontinue as appropriate if immune-mediated adverse reactions suspected. Complications of allogeneic HSCT after Poteligeo (including severe acute GVHD, steroid-refractory GVHD, transplant-related death); monitor closely. Verify pregnancy status prior to initiation. Females of reproductive potential should use effective contraception during and for ≥3 months after final dose. Pregnancy: not recommended. Nursing mothers.

Pharmacologic Class:

CCR4-directed monoclonal antibody.

Adverse Reactions:

Rash, infusion related reactions, fatigue, diarrhea, musculoskeletal pain, upper RTI, skin infection, pyrexia, nausea, edema, thrombocytopenia, headache, constipation, mucositis, anemia, cough, hypertension.

Generic Availability:

NO

How Supplied:

Single-dose vial—1

Pricing for POTELIGEO

5ml of 4mg/ml vial (Qty: 1)
Appx. price $3992
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