• Viral infections

Viral infections:

Indications for VALTREX:

Treatment of herpes labialis or herpes zoster. Treatment of initial or recurrent episodes of genital herpes in immunocompetent adults. Chronic suppression of recurrent genital herpes in immunocompetent and HIV-infected adults. Reduction of transmission of genital herpes in immunocompetent heterosexual adults. Treatment of chickenpox in immunocompetent children.

Adult:

Begin at onset of signs/symptoms (within 48hrs for herpes zoster or initial episode of genital herpes). Coincide a dose for after hemodialysis. ≥12yrs: Herpes labialis (treat for max 1 day): 2g every 12hrs; CrCl 30–49mL/min: 1g every 12hrs; CrCl 10–29mL/min: 500mg every 12hrs; CrCl <10mL/min: 500mg once. ≥18yrs: Herpes zoster: 1g every 8hrs; CrCl 30–49mL/min: 1g every 12hrs; CrCl 10–29mL/min: 1g every 24hrs; CrCl <10mL/min: 500mg every 24hrs; all for 7 days. Initial episode of genital herpes: 1g every 12hrs; CrCl 10–29mL/min: 1g every 24hrs; CrCl <10mL/min: 500mg every 24hrs; all for 10 days. Treatment of recurrent genital herpes: 500mg every 12hrs; CrCl ≤29mL/min: 500mg every 24hrs; both for 3 days. Suppression of recurrent genital herpes: in immunocompetent (>9 episodes/yr): 1g every 24hrs; CrCl ≤29mL/min: 500mg every 24hrs; (≤9 episodes/yr): 500mg every 24hrs; CrCl ≤29mL/min: 500mg every 48hrs; in HIV-infected: 500mg every 12hrs; CrCl ≤29mL/min: 500mg every 24hrs. Reduction of genital herpes transmission (≤9 episodes/yr): 500mg every 24hrs for source partner (and use safer sex practices).

Children:

Herpes labialis: <12yrs: not established. Herpes zoster or genital herpes <18yrs: not established. Chickenpox: <2yrs or ≥18yrs: not established. Begin at onset of signs/symptoms. 2–<18yrs: 20mg/kg three times daily for 5 days; max 1g three times daily. CrCl<50mL/min: no data.

Warnings/Precautions:

Risk of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in advanced HIV-1 disease or transplant recipients on 8g/day; discontinue immediately if occurs. Underlying renal disease. Maintain adequate hydration. Elderly. Pregnancy. Nursing mothers.

Pharmacologic Class:

Nucleoside analogue.

Interactions:

Caution with nephrotoxic drugs.

Adverse Reactions:

Headache, nausea, abdominal pain; acute renal failure, CNS effects (esp. elderly; discontinue if occur).

How Supplied:

Tabs—30, 90

Pricing for VALTREX

1g tablet (Qty: 30)
Appx. price $28
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