Emerging Treatments

Vitamin C Treatment May Be Beneficial for Sepsis, But Duration and Dose Unclear

Vitamin C Treatment May Be Beneficial for Sepsis, But Duration and Dose Unclear

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Vitamin C was associated with lower mortality rates, shorter lengths of ICU stay, and shorter durations of vasopressor use in patients with sepsis.

Eravacycline Now Available for Treating Complicated Intra-Abdominal Infections

Eravacycline Now Available for Treating Complicated Intra-Abdominal Infections

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As Xerava is a fully-synthetic fluorocycline antibacterial that is structurally similar to tetracyclines, treatment is contraindicated in patients with known hypersensitivity to tetracycline-class antibacterial drugs.

Glecaprevir/Pibrentasvir Is Safe, Efficacious for HCV/HIV-1 Coinfection

Glecaprevir/Pibrentasvir Is Safe, Efficacious for HCV/HIV-1 Coinfection

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Analysis of 2 phase 3 clinical trials evaluating the safety/efficacy of glecaprevir/pibrentasvir in people with HCV coinfected with HIV-1 found an overall sustained virologic response of 98% at week 12 of treatment in those with or without cirrhosis.

Once Daily Single-Tablet HIV Regimen Safe and Effective

Once Daily Single-Tablet HIV Regimen Safe and Effective

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Once-daily single-tablet regimen of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in adults who have virologic suppression of HIV-1 infection has a high efficacy and safety profile.

A Single Combination Tablet Suppresses HIV Load Through 48 Weeks

A Single Combination Tablet Suppresses HIV Load Through 48 Weeks

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A combination single tablet once-a-day regimen of doravirine/lamivudine/tenofovir disoproxil fumarate demonstrated non-inferiority and no significant adverse events when compared with continuation of established antiretroviral therapy in adults infected with HIV-1.

Continued Noninferiority of Doravirine to Efavirenz at Week 96

Continued Noninferiority of Doravirine to Efavirenz at Week 96

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The week 96 results of the DRIVE-AHEAD phase 3 noninferiority trial support noninferiority of doravirine to efavirenz in treatment-naive adults with HIV-1.

Amikacin Inhalation Suspension Approved for Mycobaterium Avium Infection

Amikacin Inhalation Suspension Approved for Mycobaterium Avium Infection

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Arikayce is intended for oral inhalation use and is administered via the Lamira Nebulizer System only.

Pediatric Phase 1 Trial Shows Ceftolozane/Tazobactam Is Safe,Tolerable

Pediatric Phase 1 Trial Shows Ceftolozane/Tazobactam Is Safe,Tolerable

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Single doses of ceftolozane and tazobactam were well tolerated in children with gram-negative bacterial infections and no safety concerns were identified.

FDA Gives MRX-I QIDP, Fast Track Status for Acute Bacterial Skin Infections

FDA Gives MRX-I QIDP, Fast Track Status for Acute Bacterial Skin Infections

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The structure of contezolid was designed to potentially reduce the risk of hematological toxicity associated with this class of antibiotics.

Baloxavir Marboxil, Safe and Effective in Treatment of Uncomplicated Influenza

Baloxavir Marboxil, Safe and Effective in Treatment of Uncomplicated Influenza

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A single dose of baloxavir marboxil was superior to placebo in controlling influenza symptoms in patients with uncomplicated disease.

Metabolic Effects of Initiating Lopinavir/Ritonavir Treatment in Children

Metabolic Effects of Initiating Lopinavir/Ritonavir Treatment in Children

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Lopinavir/ritonavir-based treatment may be associated with higher total cholesterol in young children.

Positive Results for Ceftolozane/Tazobactamin Phase 3 Study of Ventilated HABP, VABP Patients

Positive Results for Ceftolozane/Tazobactamin Phase 3 Study of Ventilated HABP, VABP Patients

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The full findings from the study will be presented at a future scientific conference; Merck plans to include the data in a supplemental New Drug Application for Zerbaxa which will be submitted to the Food and Drug Administration.

Ampicillin Plus Ceftriaxone: An Effective Alternative for <i>E faecalis</i> Infective Endocarditis

Ampicillin Plus Ceftriaxone: An Effective Alternative for E faecalis Infective Endocarditis

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Ampicillin plus ceftriaxone was an effective treatment for penicillin-susceptible Enterococcus faecalis infective endocarditis compared with ampicillin plus gentamicin.

Mulpleta Approved for Thrombocytopenia in Patients With Chronic Liver Disease

Mulpleta Approved for Thrombocytopenia in Patients With Chronic Liver Disease

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The FDA has approved Mulpleta for the treatment of thrombocytopenia in adult patients with chronic liver disease who are scheduled to undergo a procedure.

Hep B Core Antibody-Positive Organs May Provide Solutions to the Organ Donor Crisis

Hep B Core Antibody-Positive Organs May Provide Solutions to the Organ Donor Crisis

Hepatitis B core Antibody (anti-HB c+) organs may be a safe and ethical transplant option in an era where increased medical knowledge has enabled greater treatment for hepatitis.

Continuous Antibiotic Infusion via Elastomeric Pumps Safe and Effective in Outpatients

Continuous Antibiotic Infusion via Elastomeric Pumps Safe and Effective in Outpatients

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Treating outpatients with continuous infusions of flucloxacillin, cefepime, vancomycin, and piperacillin/tazobactam using elastomeric pumps was effective and safe.

Could Zika Virus Be a Potential Treatment for Neuroblastoma?

Could Zika Virus Be a Potential Treatment for Neuroblastoma?

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Even with intensive therapy, survival among neuroblastoma patients is poor, indicating a need for alternative treatments.

Zemdri Now Available for the Treatment of Complicated UTI, Pyelonephritis

Zemdri Now Available for the Treatment of Complicated UTI, Pyelonephritis

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Zemdri carries a Boxed Warning describing reports of nephrotoxicity, ototoxicity, and neuromuscular blockade, as well as fetal harm if administered during pregnancy.

TPOXX Approved for the Treatment of Human Smallpox Disease

TPOXX Approved for the Treatment of Human Smallpox Disease

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The approval was supported by findings from 12 clinical trials of TPOXX with more than 700 healthy volunteers that showed no drug-related serious adverse events.

Using Genome Mapping to Fight Antibiotic Resistance Bacteria

Using Genome Mapping to Fight Antibiotic Resistance Bacteria

Whole genome sequencing is being used by the US Food and Drug Administration to combat the global spread of antibiotic resistance bacteria.

FDA Green Lights Combination Medication for Treating HIV-1

FDA Green Lights Combination Medication for Treating HIV-1

Gilead Sciences announced that the FDA has approved emtricitabine/tenofovir alafenamide [F/TAF] (Descovy) tablets for the treatment of HIV-1 infection.

FDA Green Lights Odefsey for Treating HIV-1

FDA Green Lights Odefsey for Treating HIV-1

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Combining emtricitabine and tenofovir alafenamide (Gilead Sciences) and rilpivirine (Janssen Sciences), Odefsey is Gilead's second tenofovir alafenamide-based regimen to receive FDA approval.

Drop-to-Drop Variation Noted With Fingerprick Blood

Drop-to-Drop Variation Noted With Fingerprick Blood

Authors say variation in blood analytes holds implications for point-of-care testing.

Antiretroviral Therapy For All (Almost)

Antiretroviral Therapy For All (Almost)

An international randomized trial resolves the debate about the timing for the initiation of antiretroviral therapy for patients.

Preventive HIV Treatment Proving Effective at Health Clinics

Preventive HIV Treatment Proving Effective at Health Clinics

But uptake of PrEP lower among blacks.

Years Leading Up To Violent Conflict May Be Time of High HIV Transmission

Years Leading Up To Violent Conflict May Be Time of High HIV Transmission

The study tracked HIV incidence statistics in 36 sub-Saharan countries from 1990 through 2012 and correlated them with periods of conflict and peace in each country.

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