Accelerated Cortical Aging With Alcohol Dependence in HCV-Infected Individuals
Greater deficits were seen in those with vs those without HCV infection in frontal, precentral, superior, and orbital volumes.
HealthDay News — Alcohol dependence has deleterious effects on frontal cortical volumes that are compounded by hepatitis C virus (HCV) infection and drug dependence, according to a study published in JAMA Psychiatry.
Edith V. Sullivan, PhD, from the Stanford University School of Medicine in California, and colleagues examined cortical volume deficits using 826 structural magnetic resonance images from 222 individuals with alcohol dependence and 199 age-matched control participants. Longitudinal data were available for 116 participants with alcoholism and 96 controls.
The researchers found that participants with alcohol dependence had volume deficits in frontal, temporal, parietal, cingulate, and insular cortices; the deficits were prominent in fontal subregions and were not dependent on sex.
In the frontal cortex and precentral and superior gyri, accelerated aging occurred; this could not be attributed to the amount of alcohol consumed, which was greater in younger- vs older-onset participants with alcoholism. Smaller frontal volumes were seen for alcohol plus cocaine and alcohol plus opiate groups vs drug-dependence-free alcoholism groups.
Greater deficits were seen in those with vs those without HCV infection in frontal, precentral, superior, and orbital volumes; in uninfected participants with alcoholism, total frontal, insular, parietal, temporal, and precentral volume deficits persisted compared with control participants with known HCV status.
"We speculate that age-alcohol interactions notable in frontal cortex put older adults at heightened risk for age-associated neurocompromise even if alcohol misuse is initiated later in life," the authors write.
Sullivan EV, Zahr NM, Sassoon SA, et al. The role of aging, drug dependence, and hepatitis C cormorbidity in alcoholism cortical compromise [published online March 14, 2018]. JAMA Psychiatry. doi: 10.1001/jamapsychiatry.2018.0021