Hepatitis

Transplanting HCV-Infected Kidneys Into HCV-Infected Patients Increased Adjusted Life Expectancy

Transplanting HCV-Infected Kidneys Into HCV-Infected Patients Increased Adjusted Life Expectancy

For patients with HCV infection with end-stage renal disease, transplant of an HCV-infected kidney followed by treatment is more cost-effective than transplant of an HCV-uninfected kidney.

Keytruda sBLA Granted Priority Review for Advanced Hepatocellular Carcinoma

Keytruda sBLA Granted Priority Review for Advanced Hepatocellular Carcinoma

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The sBLA is based on results from the Phase 2 KEYNOTE-224 trial, which enrolled 104 individuals with advanced hepatocellular carcinoma previously treated with sorafenib who were either intolerant to or showed progression of disease after treatment.

Multidose Hepatitis Vaccine Adherence in US Adults May Be Suboptimal

Multidose Hepatitis Vaccine Adherence in US Adults May Be Suboptimal

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Adherence and completion to multidose vaccine schedules for hepatitis A, B, and A-B are low, thereby rendering vaccination ineffective.

Long-Term Safety Data for Tenofovir Alafenamide in Chronic Hepatitis B Added to Labeling

Long-Term Safety Data for Tenofovir Alafenamide in Chronic Hepatitis B Added to Labeling

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Vemlidy, a nucleoside analogue (reverse transcriptase inhibitor), is currently approved to treat chronic hepatitis B virus (HBV) infection in adults with compensated liver disease.

Project ECHO: Educational Support to Improve Hepatitis Care

Project ECHO: Educational Support to Improve Hepatitis Care

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Project ECHO at Los Angeles Christian Health Center contributes to improved care of HCV in underserved populations.

Demographic Insights Into Hepatitis Vaccination Practices

Demographic Insights Into Hepatitis Vaccination Practices

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From 2007 to 2015, the majority of initial hepatitis A, B, and A/B vaccinations were administered by primary care providers.

Hepatitis B Vaccines Compared in Older Adults With Type 2 Diabetes

Hepatitis B Vaccines Compared in Older Adults With Type 2 Diabetes

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For the analysis, study authors looked at data specifically for patients with type 2 diabetes aged 60 to 70 years.

Direct-Acting Antivirals Effective for Hepatitis C in Seniors

Direct-Acting Antivirals Effective for Hepatitis C in Seniors

For older patients with hepatitis C virus, direct-acting antiviral therapy is effective.

Normal on-Treatment ALT Linked to Reduced Hepatic Events in Hepatitis B

Normal on-Treatment ALT Linked to Reduced Hepatic Events in Hepatitis B

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Patients with chronic hepatitis B have a lower risk of hepatic events if they achieve normal on-treatment ALT in the first 12 months of NA treatment.

Risk for Liver Cirrhosis in Methorexate-Treated Psoriasis With Chronic Viral Hepatitis

Risk for Liver Cirrhosis in Methorexate-Treated Psoriasis With Chronic Viral Hepatitis

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Real-world data have demonstrated no rise in the development of incident liver cirrhosis among patients with psoriasis and either CHB or CHC who have received long-term MTX therapy.

Post-Transplant HCV Treatment Increases Access to Kidney Transplantation

Post-Transplant HCV Treatment Increases Access to Kidney Transplantation

Post-transplant hepatitis C treatment increases access to transplant and reduces waitlist time among hepatitis C-positive patients awaiting kidney transplantation.

CDC Issues Updated Advisory Regarding Outbreaks of Hepatitis A

CDC Issues Updated Advisory Regarding Outbreaks of Hepatitis A

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Of the 2500 cases of hepatitis A infection reported between January 2017 and April 2018, 68% were among persons who reported drug use (injection and non-injection), homelessness, or both.

Healthcare Program Obtains 93% of Prior Authorization Approvals for HCV Medications

Healthcare Program Obtains 93% of Prior Authorization Approvals for HCV Medications

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The Respectful & Equitable Access to Comprehensive Healthcare program obtained 93% of prior authorization approvals for hepatitis C medications.

HCV Guidelines Updated to Include Recommendations for Key Populations

HCV Guidelines Updated to Include Recommendations for Key Populations

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The guidelines were developed by the American Association for the Study of Liver Diseases and the Infectious Diseases Society of America.

Novel Medicaid Strategy Proposed to Increase Access to HCV Treatment

Novel Medicaid Strategy Proposed to Increase Access to HCV Treatment

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A proposed novel Medicaid purchasing strategy is anticipated to increase access to medications that can eradicate hepatitis C virus infection without increasing costs at the state and federal levels.

Two Hepatitis C Virus Infection Treatments to Be Discontinued

Two Hepatitis C Virus Infection Treatments to Be Discontinued

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The discontinuation is voluntary and is not related to product quality, safety or efficacy.

HBV Status Linked to Disease Activity and Progression in Rheumatoid Arthritis

HBV Status Linked to Disease Activity and Progression in Rheumatoid Arthritis

Patients with rheumatoid arthritis with chronic hepatitis B virus infection demonstrated greater radiographic progression and poorer clinical response at 1 year.

Hepatitis C-Exposed Infants Not Adequately Screened

Hepatitis C-Exposed Infants Not Adequately Screened

Low screening rate seen at same time as increase in hepatitis C virus prevalence among pregnant women.

Real-Life Renal Outcomes With Sofosbuvir in Chronic Hepatitis C

Real-Life Renal Outcomes With Sofosbuvir in Chronic Hepatitis C

Sofosbuvir-based treatment appears to guarantee renal safety for patients with chronic hepatitis C virus over one year of follow-up.

Methadone Maintenance Therapy Associated With Greater Access to Physician Care in HCV-Positive Drug Users

Methadone Maintenance Therapy Associated With Greater Access to Physician Care in HCV-Positive Drug Users

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The investigators suggest that enrollment in a methadone maintenance therapy program may be helpful in providing access to HCV care in people who inject drugs.

HBV Reactivation Examined in Patients Treated With TNF Antagonists

HBV Reactivation Examined in Patients Treated With TNF Antagonists

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The authors examined data from 8887 individuals who began TNF antagonist treatment for an autoimmune disease from 2001 through 2010 and were followed through 2012; 52% of these patients were screened for HBV before treatment.

Case Report: Nephrotic Syndrome and Chronic HCV in a 72-Year-Old Woman

Case Report: Nephrotic Syndrome and Chronic HCV in a 72-Year-Old Woman

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A 72-year-old Japanese woman with a 40-year history of lupus nephritis presented with leg edema that had lasted for several weeks.

Screening insufficient for newborns exposed to hepatitis C virus

In this retrospective study, only a fraction of infants receiving well-child care at the study institution were screened for hepatitis C, despite being born to mothers with a known history of hepatitis C virus infection.

Metabolic Syndrome Associated With Higher ALT Levels in Chronic Hepatitis B

Metabolic Syndrome Associated With Higher ALT Levels in Chronic Hepatitis B

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Findings highlight the importance of screening for metabolic syndrome (MS) and the potential for MS to influence alanine aminotransferase and its interpretation in the context of HBV treatment decisions.

CDC: Recommendations on the Use of Heplisav-B Published

CDC: Recommendations on the Use of Heplisav-B Published

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The CDC has published ACIP recommendations regarding the use of Heplisav-B.

Glecaprevir/Pibrentasvir Highly Efficacious for HCV/HIV Coinfection

Glecaprevir/Pibrentasvir Highly Efficacious for HCV/HIV Coinfection

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Study results support the indication of glecaprevir/pibrentasvir as the first 8-week pangenotypic treatment option for HCV/HIV-1 coinfected patients without cirrhosis.

How San Francisco Is Tackling the HIV/HCV and Opioid Epidemics

How San Francisco Is Tackling the HIV/HCV and Opioid Epidemics

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Katie Burk, MPH, presented measures undertaken by the city of San Francisco to provide integrated responses to the concurrent HIV/HCV and opioid public health epidemics.

Maternal Use of TDF Does Not Further Reduce HBV Transmission

Maternal Use of TDF Does Not Further Reduce HBV Transmission

Maternal use of tenofovir disoproxil fumarate does not lower hepatitis B virus transmission rates.

BMI Linked to Hepatocellular Carcinoma Risk in Chronic Hepatitis B Virus

BMI Linked to Hepatocellular Carcinoma Risk in Chronic Hepatitis B Virus

For patients with chronic HBV, BMI is significantly associated with increased risk of hepatocellular carcinoma.

Hepatitis C Screening Increasing Among Baby Boomers

Hepatitis C Screening Increasing Among Baby Boomers

Future research should develop interventions to increase HCV screening with special focus on groups demonstrating significantly lower screening rates, such as Hispanics and women.

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