HIV/AIDS

Glecaprevir/Pibrentasvir Is Safe, Efficacious for HCV/HIV-1 Coinfection

Glecaprevir/Pibrentasvir Is Safe, Efficacious for HCV/HIV-1 Coinfection

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Analysis of 2 phase 3 clinical trials evaluating the safety/efficacy of glecaprevir/pibrentasvir in people with HCV coinfected with HIV-1 found an overall sustained virologic response of 98% at week 12 of treatment in those with or without cirrhosis.

Once Daily Single-Tablet HIV Regimen Safe and Effective

Once Daily Single-Tablet HIV Regimen Safe and Effective

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Once-daily single-tablet regimen of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in adults who have virologic suppression of HIV-1 infection has a high efficacy and safety profile.

Common Antiretrovirals Have Same Likelihood of Certain Disorders After Initiation

Common Antiretrovirals Have Same Likelihood of Certain Disorders After Initiation

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Incidence of body fat redistribution/accumulation, pancreatic disorders, musculoskeletal disorders, IRIS, severe systemic rash, and HSR did not differ among common prescribed antiretrovirals.

A Single Combination Tablet Suppresses HIV Load Through 48 Weeks

A Single Combination Tablet Suppresses HIV Load Through 48 Weeks

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A combination single tablet once-a-day regimen of doravirine/lamivudine/tenofovir disoproxil fumarate demonstrated non-inferiority and no significant adverse events when compared with continuation of established antiretroviral therapy in adults infected with HIV-1.

Continued Noninferiority of Doravirine to Efavirenz at Week 96

Continued Noninferiority of Doravirine to Efavirenz at Week 96

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The week 96 results of the DRIVE-AHEAD phase 3 noninferiority trial support noninferiority of doravirine to efavirenz in treatment-naive adults with HIV-1.

In Utero Antiretroviral Exposure Associated With Higher Neurological Risk

In Utero Antiretroviral Exposure Associated With Higher Neurological Risk

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Children who are HIV-exposed, but uninfected, demonstrated a higher risk of adverse neurologic events during infancy and early childhood associated with ART exposure in-utero.

HIV Infection Diagnoses on the Rise in Young Homosexual Men

HIV Infection Diagnoses on the Rise in Young Homosexual Men

Number of HIV diagnoses in those aged 13 to 29 four times higher than those age 50 years or older.

Integrated Intervention Engages PLWHIV who Inject Drugs

Integrated Intervention Engages PLWHIV who Inject Drugs

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A flexible, scalable intervention increases antiretroviral therapy and medication-assisted treatment use while reducing mortality in people who inject drugs.

Cryptococcal Meningitis May Be Linked With Higher Mortality in PLWHIV

Cryptococcal Meningitis May Be Linked With Higher Mortality in PLWHIV

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Antiretroviral therapy initiation within 4 weeks of a cryptococcal meningitis diagnosis in PLWHIV appears to be associated with a higher mortality risk.

Psychosocial Factors Associated With Persistent Pain in HIV

Psychosocial Factors Associated With Persistent Pain in HIV

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A recent meta-analysis and literature review found moderate evidence supporting an association between pain outcomes in people with HIV and several psychosocial factors.

Certain Patient Characteristics May Augment Tenofovir in Viral Suppression of HIV

Certain Patient Characteristics May Augment Tenofovir in Viral Suppression of HIV

Tenofovir diphosphate in dried blood spots was strongly associated with virologic suppression in those living with HIV on TDF-based therapies.

Abacavir Linked to Increased Risk for Cardiovascular Disease in PLWHIV

Abacavir Linked to Increased Risk for Cardiovascular Disease in PLWHIV

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Exposure to abacavir is associated with an increased risk for cardiovascular disease in individuals infected with HIV.

Carotid Artery Atherosclerosis Is Associated With Mortality in Adults With HIV

Carotid Artery Atherosclerosis Is Associated With Mortality in Adults With HIV

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Carotid artery plaque was predictive of mortality, with differences observed by sex and HIV serostatus.

HIV, TB Co-Infection Associated With Decreased Neurological Performance

HIV, TB Co-Infection Associated With Decreased Neurological Performance

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Co-infection of HIV+ and tuberculosis (TB) may be associated with decreased neurological and neuropsychological functioning.

Recipients of Popular Facial May Have Been Exposed to HIV, Hepatitis

Recipients of Popular Facial May Have Been Exposed to HIV, Hepatitis

Inspection at the VIP Spa in Albuquerque detected practices that might spread HIV or hepatitis B and C.

Metabolic Effects of Initiating Lopinavir/Ritonavir Treatment in Children

Metabolic Effects of Initiating Lopinavir/Ritonavir Treatment in Children

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Lopinavir/ritonavir-based treatment may be associated with higher total cholesterol in young children.

Checkpoint Blockade Demonstrates Antitumor Activity in HIV-Associated Kaposi Sarcoma

Checkpoint Blockade Demonstrates Antitumor Activity in HIV-Associated Kaposi Sarcoma

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One patient achieved complete remission in the trial, while 5 other patients experienced partial remission.

Aptima and RealTime Assay Have High Concordance in Monitoring HIV Viral Load

Aptima and RealTime Assay Have High Concordance in Monitoring HIV Viral Load

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The Aptima assay has 6-sigma performance, high concordance with the RealTime reference assay, and is user friendly and efficient, making it a good choice for laboratories that perform routine monitoring of HIV-1 viral loads.

Ibalizumab, a Treatment Option for Multidrug Resistant HIV-1 Infection

Ibalizumab, a Treatment Option for Multidrug Resistant HIV-1 Infection

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Ibalizumab showed significant antiviral activity in patients with multidrug-resistant HIV-1 infection, advanced disease, and few other treatment options

FDA Approves Two New Oral Treatments for HIV-1 Infection

FDA Approves Two New Oral Treatments for HIV-1 Infection

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Delstrigo is approved as a complete regimen whereas Pifeltro is to be administered in combination with other antiretrovirals.

Behavioral Intervention Reduces HIV Transmission Risk in Young Transgender Women

Behavioral Intervention Reduces HIV Transmission Risk in Young Transgender Women

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A group-based behavioral intervention reduced the sexual risk for HIV infection and transmission by nearly 40% in young transgender women.

Patient Navigation Associated With Positive Outcomes in HIV

Patient Navigation Associated With Positive Outcomes in HIV

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Patient navigation may be considered an effective strategy to enhance engagement and continuation in disease treatment among people with HIV.

Smartphone App Can Help Improve Outcomes in Patients With HIV

Smartphone App Can Help Improve Outcomes in Patients With HIV

Improvements seen in retention in care, CD4 counts, and viral suppression.

HIV Viral Suppression Rates Show Increasing Trend, 1997 to 2015

HIV Viral Suppression Rates Show Increasing Trend, 1997 to 2015

Lower odds of having detectable viral load for older adults and those using ISTI-based regimen

The Nature of Stigma-Pain Relation in People Living With HIV

The Nature of Stigma-Pain Relation in People Living With HIV

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Anxiety sensitivity may explain the association between stigma and pain among people living with HIV.

Trends in HIV/AIDS Have Worsened in African-Americans

Trends in HIV/AIDS Have Worsened in African-Americans

Recommendations have been developed for addressing the HIV/AIDS epidemic in the African-American community.

Ibalizumab Active in Multidrug Resistant HIV-1 Infection

Ibalizumab Active in Multidrug Resistant HIV-1 Infection

Ibalizumab has antiviral activity among patients with multidrug resistant HIV-1 infection.

Tolerability of Switching to Long-acting Cabotegravir Plus Rilpivirine From Current HIV-1 Regimen

Tolerability of Switching to Long-acting Cabotegravir Plus Rilpivirine From Current HIV-1 Regimen

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The ATLAS study enrolled 570 patients infected with HIV-1; participants were randomized to either the experimental or active comparator arms.

FDA Updates Labeling for Several HIV Medications to Include Interaction Data With DOACs

FDA Updates Labeling for Several HIV Medications to Include Interaction Data With DOACs

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The FDA has approved labeling updates for Genvoya, Stribild and Tybost to include new drug-drug interaction data.

Previous Missed Appointments Predict Likelihood of Trend in Patients With HIV

Previous Missed Appointments Predict Likelihood of Trend in Patients With HIV

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In a large, geographically diverse sample of patients engaged in routine HIV primary care, past HIV appointment attendance emerged as the most powerful predictor of future attendance.

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