HIV/AIDS ADVISOR

HIV/AIDS Advisor

Web-Based Treatments for Depression in HIV-Infected Individuals

Depression is a common comorbidity in people living with HIV, with lifetime prevalence estimates ranging from 22% to 61%.
HIV Seroconversion Despite PrEP Therapy

The study evaluated a cohort of 14 young black, men who have sex with men in Atlanta, Georgia, who had HIV seroconversion despite treatment with PrEP.
The Effect of Chronic Pain on HIV Outcomes

Chronic pain is a frequent comorbidity in people living with HIV, with a 2014 systematic review finding a 54% point prevalence.
Mental Health Problems in Adolescents With HIV: Overview & Expert Interview

Adolescents infected with HIV have a greater risk for psychiatric hospitalizations compared with those not infected with HIV.
Dolutegravir Use During Pregnancy: What Are the Risks?

Early evidence of a heightened risk for birth defects with dolutegravir is concerning but remains to be fully established.

The Denver City Council recently passed an ordinance to allow the nation’s first supervised injection site. The Colorado General Assembly must also render an approval. A bipartisan bill to allow the site narrowly failed in a Republican-controlled Senate in 2018, but party control will change in 2019, making its passage more likely.3 Meanwhile, cities including San Francisco and Philadelphia are moving forward with their own site plans, despite warnings from the US Justice Department. Whether in Denver, San Francisco, Philadelphia, or elsewhere, expect the first supervised injection site in the United States to open in the near future, and for a legal battle to follow.

Will the First Supervised Injection Site Open in the United States This Year?

By

Tom Greenhalgh

Before the turn of the year, we predicted that the first supervised injection site would open in the United States. We revisit the debate over the efficacy and legality of these facilities and provide an update on where things stand.

Tuberculosis, x-ray

Early Prednisone Reduces TB-Related Immune Reconstitution Inflammatory Syndrome in PLWHIV

Prednisone during the first month of ART for those with HIV leads to a lower incidence of tuberculosis-related immune reconstitution inflammatory syndrome.

antiviral treatment, HIV

Combination of Lamivudine and Dolutegravir Effective in Treating HIV-1

By

Infectious Disease Advisor Contributing Writer

Combination therapy of lamivudine plus dolutegravir has shown efficacy, safety, and tolerability in people with HIV-1 infection.

Role of Highly-Active Antiretroviral Therapy

A New Pathway of HIV-2 Integrase Strand-Transfer Inhibitor Resistance

By

Virginia Schad, PharmD

A new integrase inhibitors resistance pathway in HIV-2 infected patients has been identified rendering isolates that are highly resistant.

Journal Articles

Daar ES, DeJesus E, Ruane P, et al. Efficacy and safety of switching to fixed-dose bictegravir, emtricitabine, and tenofovir alafenamide from boosted protease inhibitor-based regimens in virologically suppressed adults with HIV-1: 48 week results of a randomised, open-label, multicentre, phase 3, non-inferiority trial
[published online June 15, 2018]. doi: 10.1016/S2352-3018(18)30091-2

Fulcher JA, Hussain SK, Cook R, et al. Effects of substance use and sex practices on the intestinal microbiome During HIV-1 infection
[published online July 2, 2018]. J Infect Dis. doi: 10.1093/infdis/jiy349

Hoy JF, Richardson R, Ebeling PR, et al. Zoledronic acid is superior to tenofovir DF-switching for low bone mineral density in adults with HIV: a randomised trial
[published online June 20, 2018]. AIDS. doi: 10.1097/QAD.0000000000001911

Jarvis JN, Leeme TB, Molefi M, et al. Short course high-dose liposomal amphotericin B for HIV-associated cryptococcal meningitis: a phase-II randomized controlled trial
[published online June 26, 2018]. Clin Infect Dis. doi: 10.1093/cid/ciy515

Patient Education Materials

New York State Department of Health. 100 Questions & Answers About HIV/AIDS.

US Department of Veterans Affairs. HIV Prevention.

US Department of Veterans Affairs. Patient’s Guide to HIV Testing.

US Department of Veterans Affairs. Understanding Your HIV Positive Test Result.

Related Links (set in alphabetical order):

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Tuberculosis, x-ray

Early Prednisone Reduces TB-Related Immune Reconstitution Inflammatory Syndrome in PLWHIV