People of Hispanic ethnicity with HIV have an elevated risk for HPV-related cancers, according to study results published in Cancer.
These results indicate that clinicians should promote HPV vaccination in this population in order to reduce the disease burden from HPV-related cancers.
The researchers used data from the HIV/AIDS Cancer Match Study to determine standardized incidence ratios (SIRs) that they used to estimate cancer risk in people of Hispanic ethnicity with HIV and the general Hispanic population in the United States. The researchers compared cancer rates with incidence rate ratios (IRRs) in people living with HIV. They compared survival with hazard ratios between Hispanics and non-Hispanic whites and non-Hispanic blacks.
During 864,067 person-years of follow-up in people of Hispanic ethnicity with HIV, 502 HPV-related cancers occurred.
Compared with the general population, the risk for of all HPV-related cancers except oropharyngeal cancer was higher in people of Hispanic ethnicity with HIV (SIR range, 3.59 [cervical cancer] to 18.7 [anal cancer in men]).
In women with HIV, the researchers found that Hispanic women had higher cervical cancer rates compared with non-Hispanic white women (IRR, 1.70; 95% CI, 1.19‐2.43) but lower vulvar cancer rates compared with non-Hispanic white women (IRR, 0.40; 95% CI, 0.24‐0.67) and non-Hispanic black women (IRR, 0.62; 95% CI, 0.41‐0.95).
In men with HIV, the researchers found that Hispanic men had higher penile cancer rates compared with non-Hispanic white men (IRR, 2.60; 95% CI, 1.36‐4.96) but lower anal cancer rates compared with non-Hispanic white men (IRR, 0.54; 95% CI, 0.46‐0.63) and non-Hispanic black men (IRR, 0.65; 95% CI, 0.56‐0.77).
The results indicated that the 5‐year survival was greater than 50% across HPV‐related cancer types in people of Hispanic origin living with HIV.
Ortiz AP, Engels EA, Nogueras-Gonzalez GM, et al. Disparities in human papillomavirus-related cancer incidence and survival among human immunodeficiency virus-infected hispanics living in the United States [published online October 22, 2018]. Cancer. doi:10.1002/cncr.31702