Differential Diagnosis

  • Intact or not red blood cells secondary to bleeding in the urinary tract

  • Urinary tract infections are a common cause

  • In older individuals, malignancy must be ruled out

  • Clinical evidence for a neoplastic disease

  • History of renal trauma

  • History of blood transfusion

  • History of burns

  • Cause for renal infarction

Suggested Additional Lab Testing

For hemoglobinuria with urinary tract infection, complete blood count with white blood cell differential is useful. If hemoglobinuria might be explained by hemolytic anemia, a work-up for hemolysis, including a serum haptoglobin level, bilirubin, and lactate dehydrogenase, can be useful. Incompatibility of transfusion products with hemolysis is important to consider.