HealthDay News — Cryoablation seems promising for early breast cancer and has minimal risks, according to a study presented at the annual meeting of the American Society of Breast Surgeons, held virtually from April 29 to May 2.
Richard E. Fine, MD, from the West Cancer Center & Research Institute in Germantown, Tennessee, and colleagues examined the safety and efficacy of cryoablation for women aged 60 years and older with unifocal, ultrasound-visible invasive ductal carcinoma at least 1.5 cm in size; tumors were hormone receptor-positive, human epidermal growth factor receptor 2-negative. One hundred ninety-four patients (mean age, 75 years; mean tumor size, 7.4 mm) met the eligibility criteria and received successful cryoablation treatment per protocol, receiving a freeze-thaw-freeze cycle for 20 to 40 minutes. Patients were followed up at 6 months and then annually to 5 years.
The researchers observed no significant device-related adverse events or complications reported among the protocol-treated patients. Most adverse events were minor. Fifteen patients underwent sentinel lymph node biopsies; 1 had breast cancer-related positive sentinel lymph nodes, with no recurrence at 60 months of follow-up. Overall, 27, 1, and 148 patients underwent adjuvant radiation, received chemotherapy, and began endocrine therapy, respectively. During the follow-up visits, more than 95% of patients and 98% of physicians reported satisfaction from the cosmetic results. Only 4 of the protocol-treated patients had recurred at a mean of 34.83 months of follow-up (2.06% overall recurrence rate).
“Cryoablation potentially represents a dramatic improvement in care for appropriate low-risk patients, and at 3 years’ posttreatment, the ICE3 trial results are extremely positive,” Fine said in a statement.