HealthDay News — For children with B-cell acute lymphoblastic leukemia (B-ALL), a diet and exercise intervention might improve disease response, according to a study published online April 1 in Blood Advances.

Etan Orgel, MD, from the Cancer and Blood Disease Institute at the Children’s Hospital Los Angeles, and colleagues enrolled 40 patients aged 10 to 21 years newly diagnosed with B-ALL in the Improving Diet and Exercise in ALL trial and compared them to recent historical controls (80 participants). The intervention was intended to achieve caloric deficits of at least 20% during induction, reduce fat intake and glycemic load, and increase activity. Fat mass gain, minimal residual disease (MRD; ≥0.01%), and adherence/feasibility were assessed as trial end points.

The researchers found that the intervention did not significantly reduce median fat mass change from baseline overall (+5.1 vs +10.7%; P =.13), but in a stratified analysis, there was a benefit for overweight/obese participants (+1.5% vs +9.7%; P =.02). The intervention significantly reduced the risk for MRD after adjustment for prognostic factors (odds ratio, 0.30; 95% CI, 0.09% to 0.92%; P =.02). The adherence and feasibility thresholds were exceeded (≥75% of overall diet and ≥80% completed visits, respectively). Circulating adiponectin was increased, and insulin resistance decreased with the intervention.


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“This is the first trial to test a diet-and-exercise intervention to improve treatment outcomes from a childhood cancer,” Orgel said in a statement. “This is an exciting proof-of-concept, which may have great implications for other cancers as well.”

One author disclosed financial ties to Servier Pharmaceuticals.

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