Antipseudomonal Monotherapy Efficacious in Pneumonia
Antipseudomonal combination therapy has shown poorer efficacy than antipseudomonal monotherapy in individuals with suspected pseudomonal pneumonia.
IDWeek 2018
Glecaprevir/Pibrentasvir Is Safe, Efficacious for HCV/HIV-1 Coinfection
Analysis of 2 phase 3 clinical trials evaluating the safety/efficacy of glecaprevir/pibrentasvir in people with HCV coinfected with HIV-1 found an overall sustained virologic response of 98% at week 12 of treatment in those with or without cirrhosis.
High-Risk HPV Infection Linked With Cardiovascular Disease in Women
Women with high-risk human papillomavirus are at higher risk for developing cardiovascular disease than women without high-risk HPV
Novel Intranasal Influenza Vaccine Shows Tolerability, Safety, and High Immune Response
NasoVAX, an adenovirus-based intranasal flu vaccine, shows tolerability, safety, and higher cellular immune response compared to an injectable vaccine.
Delafloxacin Equally Effective as Vancomycin/Aztreonam for Acute Bacterial, Skin Suture Infections
Treatment with intravenous and oral delafloxacin, a fluoroquinolone antibiotic with gram-negative and gram-positive activity, was comparable to vancomycin/aztreonam in improving clinical signs and symptoms in acute bacterial and skin structure infections.
Baloxavir Marboxil Safe and Effective for High-Risk Influenza Patients
When compared to placebo, baloxavir marboxil was associated with reduced risk of influenza complications and faster recovery.
Once Daily Single-Tablet HIV Regimen Safe and Effective
Once-daily single-tablet regimen of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in adults who have virologic suppression of HIV-1 infection has a high efficacy and safety profile.
Antibiotic Prophylaxis Before Dental Procedures May Be Unnecessary
Prophylactic antibiotic prescriptions before dental procedures may not be limited to indicated cardiac diagnoses, as per present guidelines, according to a study presented at IDWeek 2018 in San Francisco.
Cure Rate of Intra-Abdominal Infection With Short vs Prolonged Therapy
No significant differences in clinical cure rates were observed between short-course and prolonged-course antimicrobial therapy in patients with intraabdominal infections.
Shorter Course Antibiotics May Be Effective for Pediatric Urinary Tract Infections
Rates of urinary tract infection recurrence after antibiotic depletion did not differ significantly between treatment durations of 7 days, 10 days, and 14 days.
PCV13 in Young Adults With Diabetes Could Avert Pneumonia Hospitalizations
PCV13 in adults age <65 years with diabetes could reduce a substantial number of pneumonia hospitalizations.
Sustained Hepatitis C Treatment Associated With Lower Risk for Cardiovascular Events
Treatment for hepatitis C is associated with a reduction in cardiovascular events.
Common Antiretrovirals Have Same Likelihood of Certain Disorders After Initiation
Incidence of body fat redistribution/accumulation, pancreatic disorders, musculoskeletal disorders, IRIS, severe systemic rash, and HSR did not differ among common prescribed antiretrovirals.
Vitamin D Deficiency Associated With Sepsis Mortality
Vitamin D deficiency is associated with increased risk for sepsis mortality in postmenopausal women, which was seen in all ages.
Probiotic Use May Not Protect Against Clostridium Difficile Infection
In patients taking multiple antibiotics, proton pump inhibitors, or histamine receptor antagonists, the concurrent use of probiotics was associated with an increased incidence of Clostridium difficile infection
Fluoroquinolones May Aid in Reducing Mortality in Community-Acquired Pneumonia
For patients with CAP, antibiotic regimens including a fluoroquinolone may reduce mortality risk by 1-2% compared to beta-lactams and cephalosporins alone.
Statins May Decrease the Risk for Active Tuberculosis
The use of statins may decrease the risk for active tuberculosis.
Daptomycin Plus Fosfomycin More Effective Than Daptomycin Monotherapy in MRSA Bacteremia
The combination of daptomycin with fosfomycin demonstrates increased efficacy in treating methicillin-resistant Staphylococcus aureus bacteremia compared with daptomycin alone.
A Single Combination Tablet Suppresses HIV Load Through 48 Weeks
A combination single tablet once-a-day regimen of doravirine/lamivudine/tenofovir disoproxil fumarate demonstrated non-inferiority and no significant adverse events when compared with continuation of established antiretroviral therapy in adults infected with HIV-1.
Antibiotic Stewardship May Aid Stepdown Therapies for Community-Acquired Pneumonia
The use of fluoroquinolones in stable patients with community-acquired pneumonia can be reduced with stewardship programs that share antibiotic use data and provide guidance for step-down therapy.
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