Patients with multidrug-resistant HIV-1 infection receiving the capsid inhibitor lenacapavir have a greater reduction in viral load than those receiving placebo.
Use of antibiotics, regardless of class, is associated with an increased risk of older-onset inflammatory bowel disease.
In this meta-analysis, researchers assessed the safety and efficacy of fluconazole compared with alternative antifungal agents for the treatment of esophageal candidiasis.
Researchers conducted a retrospective study that assessed risk factors for liver injury among hospitalized patients receiving intravenous tigecycline.
Researchers assessed the pharmacokinetics of piperacillin to determine whether standard dosing provides adequate exposure in critically ill children receiving continuous kidney replacement therapy.
Researchers assessed the effects of discontinuing antimicrobial prophylaxis within 24- vs 48-hours of clean orthopedic surgery for the prevention of health care-associated infections.
Researchers assessed the pharmacokinetic profile and safety of weight-based bedaquiline among children with multidrug-resistant tuberculosis.
Investigators sought to identify a specific set of genetic loci associated with penicillin and tetracycline antibiotic susceptibility among Neisseria gonorrhoeae isolates.
Researchers compared the effect of Gram stain-guided antibiotics with guideline-based antibiotics for the treatment of patients with ventilator-associated pneumonia.
Researchers assessed the rate of inappropriate antibiotic prescriptions among older adults diagnosed with COVID-19 infection at outpatient settings.
Researchers assessed the efficacy and interaction between the 4 most common antibiotic combinations for Escherichia coli bloodstream infections.
Researchers assessed whether a shorter duration of antibiotic therapy is associated with an increased risk for recurrent diabetic foot infection.
Researchers conducted a matched cohort study to determine whether contact isolation increases the risk for adverse events among patients with vancomycin-resistant enterococcal infections.
Researchers evaluated the use of metatranscriptomic RNA sequencing for the epidemiologic surveillance of pneumonia pathogens in patients with HIV infection.
Researchers conducted a systematic review of studies that reported on interventions to increase the rate of appropriate antibiotic dispensing in low- and middle-income countries.
Researchers conducted a study to determine whether the risk for extended-spectrum -lactamase-producing enterobacterales is associated with number of sexual partners and increased sexual activity.
Researchers conducted a study that assessed antimicrobial resistance associated with specific Escherichia coli isolates in patients infected with E coli bacteremia.
Researchers evaluated first-line treatment with arthemether-lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria infection living in areas with an increased prevalence of multidrug-resistant parasites.
Investigators evaluated the 14-day bactericidal activity of various doses of meropenem, with or without rifampin, in patients being treated for pulmonary tuberculosis.
An increase in pediatric cases of C difficile is linked to use of broad-spectrum antibiotics, recurrent infections, and a growth in highly virulent strains.