Antimicrobial Prescriptions Rise for These Hospitalized Patients

HealthDay News — Individuals hospitalized with acute mania have an increased rate of bacterial infections, as evidenced by the recent prescription of antimicrobial agents, according to a study published online in Bipolar Disorders.

Robert Yolken, MD, from the Johns Hopkins School of Medicine in Baltimore, and colleagues examined recent prescriptions of systemic antimicrobial medications in 234 individuals hospitalized for acute mania. They also examined 368 individuals hospitalized for other psychiatric disorders and 555 controls.

The researchers found that the rate of recent antimicrobial prescription, defined as exposure within three days of ascertainment, was increased for individuals hospitalized with acute mania (adjusted odds ratio, 5.5; P < 0.0002). Overall, 7.7% of individuals hospitalized for acute mania were prescribed antibiotics compared with 1.3% of controls. Antibiotic prescription correlated with being on an inpatient unit versus being in the day hospital, and having increased mania symptom severity; there was no association for other clinical ratings, demographic variables, or psychiatric medications. There was no correlation seen for hospitalization for other psychiatric disorders with recent prescription of antimicrobial medications. The most common site of infection in women was the urinary tract, while for men the most common sites were the respiratory tract and mucosal surfaces.

“The prevention and effective treatment of bacterial infections may be important interventions for the management of individuals with mania,” the authors write.


1. Yolken R, Adamos M, Katsafanas E, et al. Individuals hospitalized with acute mania have increased exposure to antimicrobial medications. Bipolar Disorders. 2016;  DOI: 10.1111/bdi.12416.