MicroRNAs are currently under investigation for various clinical applications in infectious disease because of their role in host response to infection and effects on innate and adaptive immune pathways.
Toxin enzyme immunoassay more accurately identifies severe C difficile infections from strains more likely to cause recurrence, but otherwise had similar results for complications and mortality compared with the standard nucleic acid amplification test.
It appears that the common ancestor of the modern hepatitis E virus (HEV) strains emerged approximately 6800 years ago in the period following the domestication of pigs, and natural selection has played a major role in the evolution of the codon usage of HEV open reading frames (ORFs), according to study results published in BMC…
In a randomized clinical trial, the use of lithium-heparin tubes for diversion of blood prior to aspiration of culture led to a 60% decrease in blood culture contamination compared with aspiration after obtaining culture.
Diagnosing HIV using rapid screening test may not be reliable in HIV-1 controllers, a rare group of individuals living with HIV who maintain HIV viremia at extremely low or even undetectable levels in the absence of antiretroviral treatment.
A new treatment-decision score for the diagnosis of TB in children with HIV performed well, and when used in an algorithm may facilitate prompt treatment decision making for children at a high risk for mortality.
The use of guideline recommendations from the IDSA for neuroimaging in the management of community-acquired bacterial meningitis is most likely to lead to detection of major head CT scan findings that subsequently affect clinical management.