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Testing and Antibiotic Use in Children With Community-Acquired Pneumonia
Despite national guideline recommendations and the high prevalence of viral etiology of CAP in children, the use of antibiotics remains high.
Low Rate of STI Treatment Prescription Filling in Adolescents
Less than 60% of prescriptions for the treatment of STIs in adolescents seeking care in emergency departments were filled.
CDC Opens Emergency Operations Center for Congo Ebola Outbreak
The United States is stepping up its response to a historic outbreak of Ebola in two African nations.
Quality Indicators for Optimal Outpatient Parenteral Antimicrobial Therapy
New research published in Clinical Infectious Diseases describes the systematic development of 33 quality indicators for optimal outpatient parenteral antimicrobial therapy (OPAT). According to the study authors, these quality indicators are useful to assess and improve the quality of care provided by OPAT teams. Investigators used a RAND-modified Delphi procedure to develop their set of…
Treatment Failure in COPD Exacerbations Reduced by 3-Month Azithromycin Course
Treatment failure may be significantly reduced by a 3-month course of azithromycin for acute COPD exacerbations that require hospitalization.
FDA Panel Votes on Treatment for Extensively Drug Resistant, Multidrug Resistant TB
The FDA’s Antimicrobial Drugs Advisory Committee voted in favor of pretomanid, as part of a combination regimen with bedaquiline and linezolid, for the treatment of pulmonary extensively drug resistant, treatment intolerant, or nonresponsive multidrug resistant tuberculosis.
Susceptibility of Urinary E coli Isolates to Prescribed Oral Antimicrobials
Data on the in vitro susceptibility of urinary isolates of Escherichia coli to first- and second-line empirically prescribed oral antimicrobials were published in the International Journal of Antimicrobial Agents.
Effect of Earlier Organism Identification on Vancomycin Prescribing Patterns
Earlier identification of single positive blood culture growing gram-positive cocci did not significantly influence vancomycin prescribing patterns.
Ceftolozane/Tazobactam Approved for Hospital-Acquired Bacterial Pneumonia
Zerbaxa has been approved for a new indication to treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia.
Novel Antimicrobial Combination Show Activity Against Gram-Negative Uropathogens
An intravenous combination of colistin-methanesulfonate and azidothymidine shows promise as a treatment for gram-negative uropathogens.
Evaluating Survival Management of Patients With Ebola Virus Disease
A recent study examining Ebola virus disease survival and intravenous fluid administration brings to light broader knowledge gaps about survival management that should be studied further.
Guiding Broad-Spectrum Antibiotic Use in Pneumonia: DRIP vs HCAP Criteria
In patients with community-onset pneumonia, the Drug-Resistance in Pneumonia (DRIP) score was better at guiding appropriate broad-spectrum antibiotic use compared with the Healthcare Associated Pneumonia (HCAP) criteria.
Report Lists Top Infectious Diseases Spread From Animals to Humans
The Centers for Disease Control and Prevention (CDC), the Department of the Interior (DOI), and the US Department of Agriculture (USDA) released a report listing the zoonotic diseases of most concern in the United States
Increased Carbapenem Resistance-Related Mortality in Lower Income Countries
In low- and middle-income countries, carbapenem resistance may be associated with increased mortality and length of hospital stay in patients with bloodstream infections, according to a study published in Lancet Infectious Diseases. Antimicrobial resistance is a significant economic and global health threat. Strategies such as infection control measures, new antimicrobial development, and antimicrobial stewardship are…
Uropathogenic E coli Infection Commonly Manifests As Traveler’s Diarrhea
After molecular testing, half of all travel-acquired ESBL-producing E coli strains qualified as pathogens, despite most being classified as extraintestinal pathogenic or uropathogenic.
Gentamicin Found Inferior to Ceftriaxone for Gonorrhea Treatment
Ceftriaxone remains the superior first-line treatment for gonorrhea compared with gentamicin.
Trends in Histoplasma-Associated Immune Reconstitution Inflammatory Syndrome
Although incidence of histoplasma-associated immune reconstitution inflammatory syndrome is low, it still generates significant morbidity in people living with HIV.
Prophylactic Antibiotic Cuts Infection Risk After Operative Vaginal Birth
A single dose of a prophylactic antibiotic is beneficial after operative vaginal birth and reduces the risk for confirmed or suspected maternal infection.
No Improved Outcomes With β-lactam Plus Daptomycin Therapy For S aureus
Treatment of MSSA bacteremia with a combination of β-lactam and daptomycin failed to reduce mortality compared with β-lactam monotherapy.
Macrolide Resistance Against Mycoplasma genitalium Symptomatic Male Urethritis
Mycoplasma genitalium can be the only cause of symptomatic urethritis in men who took ineffective antibiotics.
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