Estimates of Antimicrobial Use Prevalence: A Step Toward Improving Stewardship
A team of investigators conducted a survey to update prevalence estimates of hospital antimicrobial use.
Antibiotics, Antimicrobial Resistance
Antibiotics, Antimicrobial Resistance
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ESBL-Producing Enterobacterales Not a Causative Pathogen for Majority of Infections in ESBL-Producing Enterobacterales Carriers
Researchers investigated the relative proportions of ESBL-producing Enterobacterales vs non-ESBL-producing Enterobacterales infections in patients with ESBL-producing Enterobacterales colonization.
High Rates of Inappropriate Antibiotic Prescribing for Acute Sinusitis in Primary Care
A study revealed that primary care clinicians do not closely follow clinical practice guidelines with regard to antibiotic prescribing for acute sinusitis and frequently overprescribe antibiotics.
Shorter Antibiotic Treatment Duration Effective for Acute Uncomplicated Cystitis
A team of investigators conducted a systematic review and meta-analysis to assess whether a shorter-than-recommended duration of antibiotic treatment can be effective for the management of acute uncomplicated cystitis.
CDC: Penicillin-, Ciprofloxacin-Resistant Meningococci Detected in US
The CDC has reported observing a significant increase in the number of meningococcal disease cases with isolates containing a blaROB-1 β-lactamase enzyme gene, conferring resistance to penicillin antibiotics and, in some cases, ciprofloxacin as well.
Antibiotic Prescribing High in Low-, Middle-Income Countries
Antibiotic prescription rates are high in low- and middle-income countries (LMIC), with a pooled prevalence proportion of antibiotic prescribing of 52 percent.
Meta-Analysis Supports WHO-Recommended Discontinuation of Antibiotic Prophylaxis After Surgery
Researchers conducted a systematic review and meta-analysis to assess outcomes associated with ongoing antibiotic prophylaxis vs discontinuation following surgery.
Strategies for Safe Home-Based Outpatient Parenteral Antimicrobial Therapy
An interactive, in-person barrier identification and mitigation tool can ensure safe administration of home-based outpatient parenteral antimicrobial therapy.
Fecal Microbiota Transplant Improved Clinical Outcomes and Decolonized Multi-Drug Resistant Organisms
Fecal microbiota transplant (FMT) appears safe in decolonizing multi-drug resistant organisms (MDRO) from intestinal reservoirs in affected patients, even those who are highly immunosuppressed.
Antibiotic Resistance Not Found to Contribute to Mortality Associated With E coli Bloodstream Infection
The SEPTICOLI study was conducted to determine the effect of host characteristics, bacterial virulence, and antibiotic resistance on the outcomes of patients with E coli bloodstream infections.
Hydroxychloroquine With or Without Azythromycin for COVID-19 Treatment Associated With Increased Risk for QTc Prolongation
Patients treated with hydroxychloroquine alone or in combination with azithromycin for pneumonia associated with COVID-19 were found to be at increased risk for corrected QT interval prolongation.
Developing New Antimicrobial Resistance From Medical Devices Is Rare
The concern for development of new resistance to central lines coated with antimicrobial combinations was not validated by current clinical and experimental evidence.
Personalized Prophylaxis for Patients With ESBL Carriage Reduces Surgical Site Infection Risk
Screening for extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) carriage before and personalizing prophylaxis for carriers after elective colorectal surgery reduces the risk of surgical site infections.
Linezolid-Containing Regimen as Empiric Treatment for Moderate to Severe Nocardiosis
Linezolid use in combination therapy is effective and as safe as other firstline treatments for moderate to severe nocardiosis.
MDRO Colonization Risk Increased With Gastric Acid Suppressant Use
The use of acid suppressants increases the odds of multidrug-resistant microorganisms (MDROs).
Pharmacokinetic Analysis of an Extended-Pulsed Fidaxomicin Regimen
Extended-pulsed fidaxomicin regimen for treatment of C difficile infection maintained fidaxomicin stool concentrations above the minimum inhibitory concentration required to inhibit the growth of 90% of organisms for 26 days.
Widespread Pbp2x Mutations Reduce S Pyogenes Beta-lactam Susceptibility
Streptococcus pyogenes strains with mutations in the pbp2x gene may have decreased susceptibility to beta-lactam antibiotics.
Widespread Pbp2x Mutations Reduce S Pyogenes Beta-lactam Susceptibility
Streptococcus pyogenes strains with mutations in the pbp2x gene may have decreased susceptibility to beta-lactam antibiotics.
Direct Challenge to Penicillin-Based Antibiotics Is Advantageous
For people who have low-risk reaction histories in an inpatient setting, direct oral challenges may be a safe, effective, and less expensive option for penicillin allergy delabeling when compared to penicillin skin testing.
CRE, CRO: Optimizing Terminologies in Carbapenemase
The terms carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant organism (CRO) are inadequate in light of new therapies.
Doxycycline, Clindamycin, Caffeine Citrate Labeling Updated With Pediatric Recommendations
Data that informed these label changes came from research funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development.
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