Developing New Antimicrobial Resistance From Medical Devices Is Rare
The concern for development of new resistance to central lines coated with antimicrobial combinations was not validated by current clinical and experimental evidence.
Antibiotics, Antimicrobial Resistance
Antibiotics, Antimicrobial Resistance
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Hydroxychloroquine With or Without Azythromycin for COVID-19 Treatment Associated With Increased Risk for QTc Prolongation
Patients treated with hydroxychloroquine alone or in combination with azithromycin for pneumonia associated with COVID-19 were found to be at increased risk for corrected QT interval prolongation.
Personalized Prophylaxis for Patients With ESBL Carriage Reduces Surgical Site Infection Risk
Screening for extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) carriage before and personalizing prophylaxis for carriers after elective colorectal surgery reduces the risk of surgical site infections.
Linezolid-Containing Regimen as Empiric Treatment for Moderate to Severe Nocardiosis
Linezolid use in combination therapy is effective and as safe as other firstline treatments for moderate to severe nocardiosis.
MDRO Colonization Risk Increased With Gastric Acid Suppressant Use
The use of acid suppressants increases the odds of multidrug-resistant microorganisms (MDROs).
Pharmacokinetic Analysis of an Extended-Pulsed Fidaxomicin Regimen
Extended-pulsed fidaxomicin regimen for treatment of C difficile infection maintained fidaxomicin stool concentrations above the minimum inhibitory concentration required to inhibit the growth of 90% of organisms for 26 days.
Widespread Pbp2x Mutations Reduce S Pyogenes Beta-lactam Susceptibility
Streptococcus pyogenes strains with mutations in the pbp2x gene may have decreased susceptibility to beta-lactam antibiotics.
Widespread Pbp2x Mutations Reduce S Pyogenes Beta-lactam Susceptibility
Streptococcus pyogenes strains with mutations in the pbp2x gene may have decreased susceptibility to beta-lactam antibiotics.
Direct Challenge to Penicillin-Based Antibiotics Is Advantageous
For people who have low-risk reaction histories in an inpatient setting, direct oral challenges may be a safe, effective, and less expensive option for penicillin allergy delabeling when compared to penicillin skin testing.
CRE, CRO: Optimizing Terminologies in Carbapenemase
The terms carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant organism (CRO) are inadequate in light of new therapies.
Doxycycline, Clindamycin, Caffeine Citrate Labeling Updated With Pediatric Recommendations
Data that informed these label changes came from research funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development.
Multiple-Dose Fosfomycin for Complicated UTIs
In cases of complicated urinary tract infections (UTI) treated with multiple-dose fosfomycin, clinical resolution occurred in 2 of 3 treatment episodes.
Decreased Antibiotic Susceptibility of S pneumoniae Strains
Nasopharyngeal pneumococcal and acute otitis media isolates from children have exhibited reduced susceptibility to several antibiotic classes after the introduction of PCV-13.
Vancomycin for Acute Bacterial Skin and Skin Structure Infection
Using oral antibiotics when possible and limiting the durations of vancomycin treatment may decrease vancomycin-associated acute kidney injury in patients with acute bacterial skin and skin structure infections.
Pneumonia Mortality Not Improved With Empiric Anti-MRSA Therapy
Anti-methicillin-resistant Staphylococcus aureus (MRSA) therapy in addition to standard pneumonia therapy does not improve mortality.
Normal Dose Moxifloxacin Maintained Effectiveness in Rifampin-Resistant TB
A short, 9-month regimen of normal dose moxifloxacin maintained good effectiveness up to 24 months after therapy cessation in patients with rifampicin-resistant tuberculosis.
Infection Prevention Is Widely Practiced Across Veterans Affairs Hospitals
Veterans Affairs hospitals adopted more infection prevention practices than non-VA hospitals.
High Prevalence of Antibiotic Use in First Nations Communities
A high prevalence of antibiotic use and skin and soft tissue infections caused by community-acquired methicillin-resistant Staphylococcus aureus were identified in Indigenous Canadian communities.
Tobramycin/Dexamethasone Suspension Available for Inflammatory Eye Conditions With Bacterial Infection
Tobradex ST contains tobramycin, an antibacterial drug, and dexamethasone, a potent corticosteroid.
First Generic of Daraprim Gets FDA Approval
Pregnant women and patients with weakened immune systems (eg, HIV or AIDS) are most susceptible to severe complications from the infection.
Repeated Courses of Antibiotics Linked to Hospital Admissions
Repeated courses of antibiotics may be associated with adverse outcomes, including admissions for infection-related complications.
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