A team of investigators conducted a systematic review and meta-analysis to assess whether a shorter-than-recommended duration of antibiotic treatment can be effective for the management of acute uncomplicated cystitis.
The CDC has reported observing a significant increase in the number of meningococcal disease cases with isolates containing a blaROB-1 β-lactamase enzyme gene, conferring resistance to penicillin antibiotics and, in some cases, ciprofloxacin as well.
Screening for extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) carriage before and personalizing prophylaxis for carriers after elective colorectal surgery reduces the risk of surgical site infections.
Extended-pulsed fidaxomicin regimen for treatment of C difficile infection maintained fidaxomicin stool concentrations above the minimum inhibitory concentration required to inhibit the growth of 90% of organisms for 26 days.
For people who have low-risk reaction histories in an inpatient setting, direct oral challenges may be a safe, effective, and less expensive option for penicillin allergy delabeling when compared to penicillin skin testing.