Does Doxycycline Cause Tooth Discoloration in Younger Patients?
Short-term use of doxycycline in pediatric patients younger than 8 years old does not appear to discolor teeth or weaken tooth enamel.
Antibiotics, Antimicrobial Resistance
Antibiotics, Antimicrobial Resistance
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Most US Adults Are Concerned About Antibiotic Resistance
Most US adults have heard of and are concerned about antibiotic resistance, but 45% report having not taken antibiotics as prescribed.
Mycoplasma genitalium/Chlamydia Coinfection: Prevalence and Macrolide Resistance Incidence
A recent study evaluated the frequency and characteristics that predicted coinfection of M genitalium and chlamydia in women.
Serotype Replacement in Childhood Invasive Pneumococcal Disease
Understanding the pneumococcal population dynamics will drive an effective next-generation vaccine design.
Polymyxin B and Sertraline Show Synergistic Activity Against P aeruginosa
The combination of polymyxin B with sertraline exhibited in vitro synergistic activity against highly polymyxin-resistant Pseudomonas aeruginosa isolates from the lungs of patients with cystic fibrosis.
Characteristics of Risk Factors and Outcomes in Carbapenem-Resistant P aeruginosa
Compared with patients who have CSPA pneumonia, patients with CRPA pneumonia were more likely to be men and admitted from skilled nursing facilities and more often require mechanical ventilation.
Pathogens in Uncomplicated UTI Commonly Resistant to Empiric Treatment
A significant percentage of patients with uncomplicated urinary tract infection (UTI) are treated with an empiric antibiotic agent to which the etiologic bacteria is resistant.
Ceftobiprole Activity Against Bacterial Skin and Soft Tissue Pathogens
Ceftobiprole was highly active against most clinical isolates of the major Gram-positive and Gram-negative skin and soft tissue infection pathogen groups.
Fosfomycin for Injection: ZEUS Study Updates
Fosfomycin for injection may show promise and noninferiority compared with standard treatment for complicated urinary tract infections.
Novel Antimicrobial Agent Shows Promise Against Gram-Negative Bacteria
A new antimicrobial agent, known as ADC56, has shown efficacy and selectivity in vitro and in vivo against Gram-negative pathogens.
Delafloxacin Receives FDA’s Priority Review for Community-Acquired Bacterial Pneumonia
The sNDA is supported by data from the phase 3, double blind, DEFINE-CABP trial (N=860) which compared the safety and efficacy of Baxdela to moxifloxacin for the treatment of CABP.
Scabies and Impetigo Prevalence After Ivermectin/Azithromycin Mass Drug Administration
Coverage with 2-dose ivermectin-based mass drug administration may have a large and sustained effect on disease prevalence.
Testing and Antibiotic Use in Children With Community-Acquired Pneumonia
Despite national guideline recommendations and the high prevalence of viral etiology of CAP in children, the use of antibiotics remains high.
Treatment Options for Methicillin-Resistant Staphylococcus Aureus Pneumonia Evaluated
Evidence for the treatment of MRSA pneumonia with trimethoprim-sulfamethoxazole, clindamycin, doxycycline, or minocycline was found to be based on limited data.
Low Rate of STI Treatment Prescription Filling in Adolescents
Less than 60% of prescriptions for the treatment of STIs in adolescents seeking care in emergency departments were filled.
Quality Indicators for Optimal Outpatient Parenteral Antimicrobial Therapy
New research published in Clinical Infectious Diseases describes the systematic development of 33 quality indicators for optimal outpatient parenteral antimicrobial therapy (OPAT). According to the study authors, these quality indicators are useful to assess and improve the quality of care provided by OPAT teams. Investigators used a RAND-modified Delphi procedure to develop their set of…
Treatment Failure in COPD Exacerbations Reduced by 3-Month Azithromycin Course
Treatment failure may be significantly reduced by a 3-month course of azithromycin for acute COPD exacerbations that require hospitalization.
FDA Panel Votes on Treatment for Extensively Drug Resistant, Multidrug Resistant TB
The FDA’s Antimicrobial Drugs Advisory Committee voted in favor of pretomanid, as part of a combination regimen with bedaquiline and linezolid, for the treatment of pulmonary extensively drug resistant, treatment intolerant, or nonresponsive multidrug resistant tuberculosis.
Susceptibility of Urinary E coli Isolates to Prescribed Oral Antimicrobials
Data on the in vitro susceptibility of urinary isolates of Escherichia coli to first- and second-line empirically prescribed oral antimicrobials were published in the International Journal of Antimicrobial Agents.
Effect of Earlier Organism Identification on Vancomycin Prescribing Patterns
Earlier identification of single positive blood culture growing gram-positive cocci did not significantly influence vancomycin prescribing patterns.
Most Antibiotics Prescribed Before Dental Procedures Unnecessary
Greater than 80% of antibiotics prescribed for infection prophylaxis prior to dental visits were found to be unnecessary.
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