Healthy Microbiome Is Key to Sepsis Management
The authors emphasize that sepsis treatment should be guided by the connection between the microbiota and sepsis outcomes.
Antibiotics, Antimicrobial Resistance
Antibiotics, Antimicrobial Resistance
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Previous Infection and Antibiotic Use Linked to Guillain-Barré Syndrome
Danish researchers looked into whether hospital-diagnosed and community-treated infections are important risk factors for GBS by examining the magnitude and duration of associated GBS risk.
Triple Therapy for Helicobacter pylori Eradication Safe for Adolescents
A team of investigators conducted a prospective, multicenter study to assess the safety of H pylori eradication therapy in adolescent students.
Testing for Legionella Pneumonia in Those at Risk: Room for Improvement
Is testing for Legionella pneumophila appropriate and could it impact treatment?
APPAC Trial: Uncomplicated Acute Appendicitis: Oral Antibiotics vs Intravenous Antibiotics?
Study authors compared oral moxifloxacin with combined intravenous ertapenem followed by oral levofloxacin in the managed of uncomplicated acute appendicitis.
Psychiatric Wards Need More Rigorous Infection Prevention Measures
This study determines which psychiatry specific factors contributed to a nosocomial outbreak taking place in a psychiatric department.
High Prevalence of Antibiotic Resistance in Men Having Sex with Men
The goal of this study was to assess the impact of doxycycline PEP on M genitalium, an emerging pathogen among men who have sex with men that has rising rates of antibiotic resistance.
Guidance Provided for Antibiotic Stewardship in Pediatrics
ASPs should be established to improve antibiotic prescribing, should include specialists with pediatric expertise.
Comparing Culture-Positive and -Negative Pyogenic Vertebral Osteomyelitis
The goal of this study is to investigate the antimicrobial therapy, therapeutic response, and outcome of culture-negative PVO compared with culture-positive PVO.
Alcaligenes faecalis: An Emerging Extensively Drug-Resistant Bacterium
Retrospective analysis was conducted to assess the presence of A faecalis infection, extensively drug-resistant A faecalis infection, and the susceptibility of commonly used antibiotics for the treatment of A faecalis and XDR A faecalis.
Mass Azithromycin Distribution Associated With Antibiotic Resistance
Investigators assessed the effect of mass distribution of azithromycin to preschool children on the gut resistome.
Infectious Diseases Consultation Effectively Reduces Antibiotic Use in Hospitals
Investigators assessed whether a daily service of infectious disease consultation was more effective than weekly consultation to reduce antibiotic use without worsening clinical outcomes.
Antibiotics Noninferior to Appendectomy for Appendicitis Treatment
Investigators proposed antibiotic therapy as an alternative to surgery for the treatment of appendicitis.
Physician Approval Prior to PICC Placement Lowers Complications
Study authors evaluated whether infectious disease physician approval prior to PICC placement for intravenous antimicrobials is associated with more appropriate device use and fewer complications.
Low Rates of Bacterial Co-Infections in COVID-19 Patients
Study authors analyzed microbiological data on COVID-19 patients to assess for bacterial co-infections associated with antimicrobial therapy.
MERINO Trial, Post-Hoc Analysis: Relationship Between MIC and 30-Day Mortality
Study authors assessed the association of piperacillin/tazobactam MIC, meropenem MIC, and beta-lactam resistance genes with mortality in the MERINO trial.
Displacement of Commensal Skin Microbes Post Colorectal Surgery
Investigators characterized temporal and spatial variation in the skin microbiota of patients undergoing colorectal surgery and to determine if dysbiosis contributes to surgical site infections.
Oral Beta-Lactams Effective Step-Down Therapy for Bacteremic UTI
Study authors compared clinical cure in patients with E coli bacteremic UTI who were stepped down to oral beta-lactams compared to oral fluoroquinolones.
Assessing the Effect of Antimalarial Drug Shortages in Rheumatic Disease During the COVID-19 Pandemic
The COVID-19 Global Rheumatology Alliance Patient Experience Survey was used to assess the effect of antimalarial drug shortages during the COVID-19 pandemic.
CREDIBLE-CR: Cefiderocol Effective for Serious Carbapenem-Resistant Gram-Negative Infections
Study authors assessed the efficacy and safety of cefiderocol vs best available therapy in adults with serious carbapenem-resistant Gram-negative infections.
APEKS-NP: Cefiderocol Non-Inferior to Meropenem for Nosocomial, Gram-Negative Pneumonia
Researchers compared the efficacy and safety of cefiderocol vs high-dose, extended-infusion meropenem for adults with nosocomial pneumonia.
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