HealthDay News — Zika virus may lead to lifelong vision impairment in affected infants, according to research published  in JAMA Ophthalmology.

The case series included 43 infants with microcephaly born in Colombia and Venezuela. Their mothers showed no signs of eye issues. The babies in the study were evaluated from October 2015 to June 2016.

The team observed substantial anterior and posterior segment abnormalities, including congenital glaucoma in 5 patients (12%) and macular or optic nerve abnormalities in 38 (88%).

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“These findings suggest that all infants with microcephaly associated with clinically diagnosed Zika virus should undergo evaluation for ophthalmic findings,” the researchers write.

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Yepez JB, Murati FA, Pettito M, et al. Opthalmic manifestations of congenital Zika syndrome in Colombia and Venezuela [published online April 13, 2017]. JAMA. doi:10.1001/jamaophthalmol.2017.0561