GI Illness

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GI Illness

Rotavirus Vaccination Reduces Children Hospitalizations and Deaths

By

Zahra Masoud

With increasing numbers of countries implementing the use of the rotavirus vaccine, rotavirus and acute gastroenteritis hospitalizations and mortalities continue to show a sustained reduction.

Diagnostics

HPV Biomarkers, Survival Linked to High-Grade Esophageal Dysplasia, Adenocarcinoma

By

Bradley van Paridon

Low expression of the HPV-related marker cyclin D1 appears to be an independent prognostic marker in Barrett high-grade dysplasia and esophageal adenocarcinoma.

GI Illness

C difficile Risk and Antibiotic Prescription Choices

By

Bradley van Paridon

Large variations in Clostridioides difficile infection risk resulting from antibiotic courses used for the same indications were identified.

Pediatrics

Rotavirus Vaccination Program Linked to Sustained Reduction in Healthcare Resource Utilization

By

Infectious Disease Advisor Contributing Writer

A rotavirus vaccination program led to significant and sustained reductions in both hospitalizations and emergency department visits across the US.

GI Illness

Decreasing Prevalence of H pylori and Associated Gastric and Duodenal Ulcers

By

Lauren Dembeck, PhD

The prevalence of H pylori infection continues to fall in the general population with only 16% of all gastric and 25% of all duodenal patients with ulcer harboring H pylori.

GI Illness

Bezlotoxumab Effective for Treating Recurrent Clostridioides difficile Infection

By

Jessica Nye, PhD

Bezlotoxumab, both alone and in combination with actoxumab, was effective in preventing recurrent Clostridioides difficile infection without increased risk for adverse events.

GI Illness

Higher Microbiota Diversity Linked To Lower Risk of Mortality After Transplant

By

Jonathan Goodman, MPhil

Patients undergoing allogeneic hematopoietic cell transplantation who have greater intestinal microbiota diversity may have a lower risk for mortality.

GI Illness

SARS-CoV-2 May Also Cause Gastrointestinal Infection

By

Natasha Priya Dyal, MD

New evidence supports the possibility of gastrointestinal infection with the novel SARS-CoV-2 virus, as well as a possible feco-oral route of transmission.

GI Illness

Multiple Sclerosis Susceptibility Associated With Certain Gut Bacteria

By

Infectious Disease Advisor Contributing Writer

A network of gut bacteria species may be associated with host genetic factors that increase susceptibility to multiple sclerosis.

Clostridioides Difficile

Glutamate Dehydrogenase Test Reduces Isolation for C difficile Infection

By

Zahra Masoud

A glutamate dehydrogenase test for Clostridioides difficile may reduce unnecessary isolation time for patients.

GI Illness

Mediterranean Diet May Modulate Gut Bacteria in Seniors

For older persons, following a Mediterranean diet is associated with an increased abundance of specific taxa linked to markers of lower frailty and improved cognitive function.

GI Illness

Intestinal Microbiota Composition and Bloodstream Infection in Stem Cell Transplant Recipients

By

Infectious Disease Advisor Contributing Writer

Among recipients of allogeneic hematopoietic cell transplantation (allo-HCT), gram-negative intestinal colonization is highly predictive of bloodstream infections.

GI Illness

Association Between GI and Respiratory Illness, Income, and School Absenteeism

By

Bradley van Paridon

During the period from 2010 to 2016, parents of children from low-income households were more likely to report recent childhood GI and respiratory illnesses than parents with a higher income.

GI Illness

Elderly Patients Humoral and Mucosal Immune Responses to Norovirus

By

Bradley van Paridon

Among elderly patients with norovirus infection, salivary IgA increased as early as 5 days after onset of symptoms and correlated strongly with serum IgA titers and blockade antibodies.

GI Illness

H pylori Eradication Decreases Gastric Cancer Risk in Those With Family History

Among those who have Helicobacter pylori infection and a family history of gastric cancer in first-degree relatives, eradication treatment for H pylori reduces the risk for gastric cancer.

GI Illness

Bisphosphonate Usage Not Linked to C difficile Infections in Nursing Homes

By

Hannah Dellabella

In older adults who are long-term residents of nursing homes, there is no significant association between bisphosphonate use and Clostridiodes difficile infection.

GI Illness

Long-Duration Vancomycin May Reduce Recurrence of Clostridioides difficile

By

Infectious Disease Advisor Contributing Writer

The study researchers concluded that when compared with short-duration vancomycin therapy for the treatment of CDI, long-duration vancomycin therapy was associated with significantly lower CDI recurrence rates.

GI Illness

Association Between Population Level Secretor Status, Norovirus Genegroup

By

Bradley van Paridon

Human host genetics of local populations may drive norovirus evolution and diversity, which may have implications for vaccine development.

Clostridioides Difficile

Fidaxomicin Approved for C difficile-Associated Diarrhea in Pediatric Patients

By

Diana Ernst, RPh

The FDA has approved fidaxomicin for the treatment of Clostridioides difficile-associated diarrhea in adult and pediatric patients aged 6 months and older.

GI Illness

Fecal Microbiota Transplantation Decreases Mortality in Patients With Recurrent, Fulminant CDI

By

Infectious Disease Advisor Contributing Writer

Fecal microbiota transplantation may significantly decrease mortality in patients hospitalized with refractory severe or fulminant Clostridioides difficile infection.