With increasing numbers of countries implementing the use of the rotavirus vaccine, rotavirus and acute gastroenteritis hospitalizations and mortalities continue to show a sustained reduction.
Low expression of the HPV-related marker cyclin D1 appears to be an independent prognostic marker in Barrett high-grade dysplasia and esophageal adenocarcinoma.
Large variations in Clostridioides difficile infection risk resulting from antibiotic courses used for the same indications were identified.
A rotavirus vaccination program led to significant and sustained reductions in both hospitalizations and emergency department visits across the US.
The prevalence of H pylori infection continues to fall in the general population with only 16% of all gastric and 25% of all duodenal patients with ulcer harboring H pylori.
Bezlotoxumab, both alone and in combination with actoxumab, was effective in preventing recurrent Clostridioides difficile infection without increased risk for adverse events.
Patients undergoing allogeneic hematopoietic cell transplantation who have greater intestinal microbiota diversity may have a lower risk for mortality.
New evidence supports the possibility of gastrointestinal infection with the novel SARS-CoV-2 virus, as well as a possible feco-oral route of transmission.
A network of gut bacteria species may be associated with host genetic factors that increase susceptibility to multiple sclerosis.
A glutamate dehydrogenase test for Clostridioides difficile may reduce unnecessary isolation time for patients.
For older persons, following a Mediterranean diet is associated with an increased abundance of specific taxa linked to markers of lower frailty and improved cognitive function.
Among recipients of allogeneic hematopoietic cell transplantation (allo-HCT), gram-negative intestinal colonization is highly predictive of bloodstream infections.
During the period from 2010 to 2016, parents of children from low-income households were more likely to report recent childhood GI and respiratory illnesses than parents with a higher income.
Among elderly patients with norovirus infection, salivary IgA increased as early as 5 days after onset of symptoms and correlated strongly with serum IgA titers and blockade antibodies.
Among those who have Helicobacter pylori infection and a family history of gastric cancer in first-degree relatives, eradication treatment for H pylori reduces the risk for gastric cancer.
In older adults who are long-term residents of nursing homes, there is no significant association between bisphosphonate use and Clostridiodes difficile infection.
The study researchers concluded that when compared with short-duration vancomycin therapy for the treatment of CDI, long-duration vancomycin therapy was associated with significantly lower CDI recurrence rates.
Human host genetics of local populations may drive norovirus evolution and diversity, which may have implications for vaccine development.
The FDA has approved fidaxomicin for the treatment of Clostridioides difficile-associated diarrhea in adult and pediatric patients aged 6 months and older.
Fecal microbiota transplantation may significantly decrease mortality in patients hospitalized with refractory severe or fulminant Clostridioides difficile infection.