Fecal Microbiota Transplantation Superior to Fidaxomicin for Recurrent C Difficile Infection
Data from a study presents compelling evidence for the superiority of FMT in multiply recurrent CDI.
Clostridioides Difficile
Clostridioides difficile
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Guidelines Issued for Clostridioides difficile Management in Adults
Authors recommend against probiotics for prevention of CDI; in those with CDI recurrence, FMT recommended to prevent further recurrence.
Overcoming Current Challenges in the Development of Microbiome Drugs
To develop microbiome drugs, scientists will need to address challenges in safety, uniformity, and delivery.
Disinfectant Wipes Transfer C Difficile Spores
Study authors tested the effect of disinfectant wipes on spore loads and cross-contamination risk for Clostridioides difficile.
Revised Clostridioides difficile Practice Guidelines Had Significant Effect on Treatment Decisions
Publication of the revised clinical practice guidelines for Clostridioides difficile infection was followed by significant increases in use of oral vancomycin and fidaxomicin, and a significant decrease in use of oral metronidazole.
Microbiome-Based Therapy Looks Promising for Recurrent C Difficile Infection
“These positive preliminary findings represent a major step forward towards bringing an innovative, non-antibiotic option to patients that may help restore their gut microbiome,” said Per Falk, Ferring’s President and Chief Science Officer.
National Burden of C difficile Infection Decreased From 2011 Through 2017
As a result of a decline in healthcare–associated infections, the estimated burden of Clostridioides difficile infection in the United States decreased by an adjusted 24% from 2011 through 2017.
Burden of Clostridioides difficile Infection Down in the U.S.
From 2011 to 2017, there was a decrease in the estimated national burden of Clostridium difficile infection.
Changes in Microbiota Predictive of Recurrent C Difficile Infection Risk
Features of fecal microbiota at baseline and after antibiotic therapy may be predictive of recurrent Clostridiodes difficile infection in patients with and without ulcerative colitis.
Glutamate Dehydrogenase Test Reduces Isolation for C difficile Infection
A glutamate dehydrogenase test for Clostridioides difficile may reduce unnecessary isolation time for patients.
Fidaxomicin Approved for C difficile-Associated Diarrhea in Pediatric Patients
The FDA has approved fidaxomicin for the treatment of Clostridioides difficile-associated diarrhea in adult and pediatric patients aged 6 months and older.
Prevalence and Length of Hospital Stay for Clostridioides difficile Infections
Clostridioides difficile infection is associated with a large burden on the healthcare system in the United States.
Dual Therapy for C difficile Infection Not Superior to Vancomycin Alone
Dual therapy with intravenous metronidazole and oral vancomycin is not superior to oral vancomycin alone in the treatment of Clostridioides difficile infections.
One in 10 Hospital Patients May Carry C difficile at Admission
Asymptomatic carriers of C. difficile at significant risk for progression to symptomatic infection
Toxin Enzyme Immunoassay Identifies Severe Clostridioides difficile Infections
Toxin enzyme immunoassay more accurately identifies severe C difficile infections from strains more likely to cause recurrence, but otherwise had similar results for complications and mortality compared with the standard nucleic acid amplification test.
Incidence of Bloodstream Infections Lower in Recurrent CDI With Fecal Transplant
Patients with recurrent Clostridioides difficile infection (CDI) were less likely to develop bloodstream infections (BSI) if treated with fecal microbiota transplantation (FMT) compared with antibiotics.
Latest Evidence and Clinical Guidance to Reduce Clostridioides difficile Infection Recurrence
Studies present promising therapeutic options to reduce recurrent CDI, as well as strategies to improve favorable economic outcomes.
Detection of Fecal C difficile Toxins of High Importance in Diagnosis
Detection of Clostridioides difficile toxins in fecal matter can lead to accurate diagnosis of C difficile infection.
Substantial Costs Attributable to Hospital-Acquired C Difficile
Direct costs come from extended length of stay and increased hospitalization costs
Best Laboratory Practices for Clostridioides difficile Diagnosis in Adults
Repeat testing of nucleic acid amplification tests is not recommended for detection of the presence of Clostridioides (formerly Clostridium) difficile in adults.
Effect of Diagnostic Test on Hospital Length of Stay for Patients with C difficile
The use of a nucleic acid assay (NAAT) for diagnosing Clostridium difficile infection demonstrated a significant reduced length of stay (LOS) for patients compared with a multi-step enzyme immunoassay-based strategy, according to data presented at the American Society for Microbiology (ASM) Microbe 2019, held in San Francisco, California, from June 20 to 24, 2019. C…
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