Drinking Coffee Reduces Mortality in HIV/HCV Coinfection

HealthDay News — Drinking 3 or more cups of coffee per day halves all-cause mortality risk in patients co-infected with HIV/hepatitis C virus (HCV), according to a study published in the Journal of Hepatology.

Maria Patrizia Carrieri, from Aix Marseille University in France, and colleagues used data (both medical and psychosocial/behavioral) from a prospective cohort of patients co-infected with HIV/HCV to assess the effect of elevated coffee consumption (at least three cups per day) at baseline on all-cause mortality over a five-year follow-up period.

The researchers found that 77 deaths occurred over the study period among 1028 patients (mortality rate 1.64/100 person-years). 

HCV-related diseases (n = 33), cancers unrelated to AIDS/HCV (n = 9), and AIDS (n = 8) were the leading causes of death. At the first available visit, 26.6% of patients reported elevated coffee consumption. After adjustment for gender and psychosocial, behavioral, and clinical factors, elevated coffee consumption at baseline was associated with a 50% reduced risk of all-cause mortality (hazard ratio, 0.5).

“The benefits of coffee extracts and supplementing dietary intake with other anti-inflammatory compounds need to be evaluated in this population,” conclude the authors.

Several authors disclosed financial ties to the pharmaceutical industry, which partially funded the study.

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Carrieri MP, Protopopescu C, Marcellin F, et al. Protective effect of coffee consumption on all-cause mortality of French HIV-HCV co-infected patients. J Hepatol. 2017 Dec;67(6):1157-1167.