Understanding the Oncogenic Role of HIV in Burkitt Lymphoma
While the rate of certain HIV-linked non-Hodgkin lymphomas has declined since the introduction of ART, the incidence of Burkitt lymphoma has remained steady.
HIV/AIDS
HIV/AIDS
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Neurocognitive Conditions Among People Living With HIV
Neurologic conditions associated with HIV remain major contributors to morbidity and mortality, and are increasingly recognized in the aging population of individuals living with HIV. -
An Overview of HIV-Associated Neurocognitive Disorder
Rates of HIV-associated dementia have decreased from approximately 50% in the pre-cART era to 2% currently. However, roughly 50% of patients treated with cART have the milder forms of HIV-associated neurocognitive disorder (HAND). -
AHA Guidelines for Prevention and Management of Cardiovascular Disease in HIV
A scientific statement from the American Heart Association was published in Circulation, with the purpose of providing a thorough review of available evidence on HIV-associated cardiovascular disease. -
Improving HIV Prevention for Underserved, At-Risk Populations
This article describes the populations at high risk for HIV infection and reports the results of a collaborative, multifaceted educational intervention designed to reduce the documented disparities related to HIV care and prevention.
Latest News
Switching From TDF to TAF or Dual-Therapy Regimens in HIV Patients
Investigators conducted a prospective analysis in patients with HIV to assess the rate of switching from TDF-based to TAF-based or dual therapy regimens and to assess the impact of switching on eGFR.
Well-Controlled HIV Infection Not Associated With Progression of Subclinical Atherosclerosis
A major concern in people with HIV includes accelerated atherosclerosis, underlined by increased rates of coronary artery disease. Researchers investigated the longitudinal progression of atherosclerosis in persons with HIV vs without HIV in the Swiss population.
Risk of Diabetes Mellitus in HIV Patients With Associated cART Initiation
Researchers assessed the risk of diabetes mellitus, weight gain, and their relationships with integrase inhibitor-based initial antiretroviral therapy among persons with HIV in the United States and Canada.
Glecaprevir/Pibrentasvir Effective in Wide Range of Frail HCV Subpopulations
Italian investigators conducted a prospective, multicenter study to assess the safety and effectiveness of glecaprevir/pibrentasvir in chronic hepatitis C patients and their subpopulations.
Rising Costs of HIV Preexposure Prophylaxis May Hinder Benefit and Decrease Access
Researchers conducted a retrospective cohort study to analyze national trends in drug payments and other associated costs of HIV PrEP treatment.
Persistent ALT Elevation in HIV-HBV Coinfection May Signal Coexisting Fatty Liver Disease
Patients with persistent ALT elevation despite controlled HBV should undergo evaluation for metabolic risk and fatty liver disease.
Switch From Efavirenz to Integrase Strand Transfer Inhibitors Related to Weight Gain
Researchers studied 61 HIV-infected individuals who switched from efavirenz- to integrase strand transfer inhibitor (INSTI)-based therapies.
Darunavir Resistance Development Is Rare in HIV Treatment
Researchers evaluated the results of multiple phase 2 and phase 3 clinical trials and found that drug resistance to darunavir, an HIV protease inhibitor, is rare.
High-Quality TB Drugs, ART Reduce Death From Multidrug-Resistant TB in HIV
A team of investigators conducted an individual patient data meta-analysis to evaluate how treatment for tuberculosis and antiretroviral therapy affect the risk of mortality in patients with HIV and multidrug-resistant tuberculosis.
Alcohol Use in HIV Associated With Intestinal Dysbiosis, CD8+ T-Cell Dysfunction
In post-hoc analyses, researchers analyzed alcohol use data and whole-blood samples from 359 participants in the New Orleans Alcohol Use in HIV study to explore the association between intestinal leak, dysbiosis, and T cells.
Dovato Use Expanded to Include Virologically Suppressed Adults With HIV-1
Previously, Dovato was only approved for treatment-naïve adults.
Novel Immunoassay Demonstrates Predictive Utility in PrEP Adherence, HIV Protection
A novel tenofovir urine immunoassay demonstrated predictive utility and may adequately determine PrEP adherence.
Brodalumab for the Treatment of Psoriasis in Patients With HIV
A first clinical experience with brodalumab in an HIV-positive patient proves successful and may imply the utility of brodalumab in this patient group.
Efficacy of Bundled HIV, HCV Testing for People With Substance Abuse Disorders Examined
By providing bundled HIV and HCV testing, substance use disorder treatment programs may create increased awareness of infection status among people with substance abuse disorders.
Elevated Inflammatory Markers in HIV May Lead to Worse Outcomes in COVID-19
Despite treatment with antiretroviral therapies, people with HIV may be more likely to experience severe manifestations of COVID-19.
Male Sex and Obesity Independently Associated With Residual HIV-1 Viremia Despite Suppressive ART
A cross-sectional study was performed to assess whether age, body mass index, and/or components of antiretroviral therapy contributed to persistence of HIV viremia.
Comparison of Systematic vs Test-Guided Treatment for TB in Adults With HIV
A team of investigators conducted a randomized trial comparing test-guided management of tuberculosis with systematic empirical treatment for adults with HIV infection.
Ethical Considerations for HIV Phylogenetic Research
A working group comprising members with expertise in virology, molecular epidemiology, public health, bioethics, community engagement, social work, community-based HIV research, and law was assembled to address ethical challenges in US-based HIV phylogenetic research.
Long-Acting Drug Targeting Capsid Protein Promising for HIV
A small molecule that disrupts the functions of the HIV capsid protein, GS-6207, demonstrates a reduction in plasma viral load and shows sustained plasma exposure.
Efforts to Reduce New HIV Infections in Children Faltering
Efforts to reduce new HIV infections in children worldwide are faltering.
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