Understanding the Oncogenic Role of HIV in Burkitt Lymphoma
While the rate of certain HIV-linked non-Hodgkin lymphomas has declined since the introduction of ART, the incidence of Burkitt lymphoma has remained steady.
HIV/AIDS
HIV/AIDS
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Neurocognitive Conditions Among People Living With HIV
Neurologic conditions associated with HIV remain major contributors to morbidity and mortality, and are increasingly recognized in the aging population of individuals living with HIV. -
An Overview of HIV-Associated Neurocognitive Disorder
Rates of HIV-associated dementia have decreased from approximately 50% in the pre-cART era to 2% currently. However, roughly 50% of patients treated with cART have the milder forms of HIV-associated neurocognitive disorder (HAND). -
AHA Guidelines for Prevention and Management of Cardiovascular Disease in HIV
A scientific statement from the American Heart Association was published in Circulation, with the purpose of providing a thorough review of available evidence on HIV-associated cardiovascular disease. -
Improving HIV Prevention for Underserved, At-Risk Populations
This article describes the populations at high risk for HIV infection and reports the results of a collaborative, multifaceted educational intervention designed to reduce the documented disparities related to HIV care and prevention.
Latest News
Persistent ALT Elevation in HIV-HBV Coinfection May Signal Coexisting Fatty Liver Disease
Patients with persistent ALT elevation despite controlled HBV should undergo evaluation for metabolic risk and fatty liver disease.
Switch From Efavirenz to Integrase Strand Transfer Inhibitors Related to Weight Gain
Researchers studied 61 HIV-infected individuals who switched from efavirenz- to integrase strand transfer inhibitor (INSTI)-based therapies.
Darunavir Resistance Development Is Rare in HIV Treatment
Researchers evaluated the results of multiple phase 2 and phase 3 clinical trials and found that drug resistance to darunavir, an HIV protease inhibitor, is rare.
High-Quality TB Drugs, ART Reduce Death From Multidrug-Resistant TB in HIV
A team of investigators conducted an individual patient data meta-analysis to evaluate how treatment for tuberculosis and antiretroviral therapy affect the risk of mortality in patients with HIV and multidrug-resistant tuberculosis.
Alcohol Use in HIV Associated With Intestinal Dysbiosis, CD8+ T-Cell Dysfunction
In post-hoc analyses, researchers analyzed alcohol use data and whole-blood samples from 359 participants in the New Orleans Alcohol Use in HIV study to explore the association between intestinal leak, dysbiosis, and T cells.
Dovato Use Expanded to Include Virologically Suppressed Adults With HIV-1
Previously, Dovato was only approved for treatment-naïve adults.
Novel Immunoassay Demonstrates Predictive Utility in PrEP Adherence, HIV Protection
A novel tenofovir urine immunoassay demonstrated predictive utility and may adequately determine PrEP adherence.
Brodalumab for the Treatment of Psoriasis in Patients With HIV
A first clinical experience with brodalumab in an HIV-positive patient proves successful and may imply the utility of brodalumab in this patient group.
Efficacy of Bundled HIV, HCV Testing for People With Substance Abuse Disorders Examined
By providing bundled HIV and HCV testing, substance use disorder treatment programs may create increased awareness of infection status among people with substance abuse disorders.
Elevated Inflammatory Markers in HIV May Lead to Worse Outcomes in COVID-19
Despite treatment with antiretroviral therapies, people with HIV may be more likely to experience severe manifestations of COVID-19.
Male Sex and Obesity Independently Associated With Residual HIV-1 Viremia Despite Suppressive ART
A cross-sectional study was performed to assess whether age, body mass index, and/or components of antiretroviral therapy contributed to persistence of HIV viremia.
Comparison of Systematic vs Test-Guided Treatment for TB in Adults With HIV
A team of investigators conducted a randomized trial comparing test-guided management of tuberculosis with systematic empirical treatment for adults with HIV infection.
Ethical Considerations for HIV Phylogenetic Research
A working group comprising members with expertise in virology, molecular epidemiology, public health, bioethics, community engagement, social work, community-based HIV research, and law was assembled to address ethical challenges in US-based HIV phylogenetic research.
Long-Acting Drug Targeting Capsid Protein Promising for HIV
A small molecule that disrupts the functions of the HIV capsid protein, GS-6207, demonstrates a reduction in plasma viral load and shows sustained plasma exposure.
Efforts to Reduce New HIV Infections in Children Faltering
Efforts to reduce new HIV infections in children worldwide are faltering.
Action Kit for Health Care Organizations Implementing PrEP Programs
Fenway Health has created a PrEP Action Kit that provides a roadmap for other health care organizations to implement and/or advance existing PrEP prescription programs.
Rukobia Approved for Heavily Treatment-Experienced HIV Patients With Limited Options
The FDA has approved Rukobia (fostemsavir; ViiV Healthcare), in combination with other antiretrovirals, for the treatment of HIV-1 infection in heavily treatment-experienced adults with multidrug-resistant HIV-1 infection failing their current antiretroviral regimen due to resistance, intolerance, or safety considerations.
Variation in Assays that Identify Early HIV Antibody Seroconversion
A study evaluated 5 commercially available assays that are approved for HIV seropositivity confirmation and could be readily performed in clinical laboratories.
CDC: HIV Testing Occurs at <1% of Physician Visits
HIV testing occurs at less than 1 percent of physician office and emergency department visits and at less than 3 percent of community health center (CHC) visits.
Factors Contributing to Poor ART Adherence, HIV-1 Drug Resistance Explored
HIV-positive patients in the United States face significant challenges associated with poor adherence to antiretroviral therapy (ART) and HIV-1 drug resistance, according to a study published in AIDS and Behavior.
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