HealthDay News — HIV-seropositive women with cervical intraepithelial neoplasia (CIN) grade ≥3 (CIN3+) are less likely to have human papillomavirus (HPV) 16, according to a study published in the American Journal of Obstetrics & Gynecology.

L. Stewart Massad, MD, from the Washington University School of Medicine in St. Louis, and colleagues screened HIV-seropositive and HIV-seronegative women with CIN3+. Polymerase chain reaction assays were used to detect DNA from more than 40 HPV types in cervicovaginal lavage specimens obtained at the visit during which CIN3+ was diagnosed.

The researchers detected HPV16 in 62% of 21 HIV-seronegative women with CIN3+ and in 29% of 154 HIV-seropositive women with CIN3+ (P = 0.01). After controlling for covariates, the lower prevalence of HPV16 in CIN3+ among HIV-seropositive women persisted (odds ratio, 0.25; 95 percent confidence interval, 0.08 to 0.78). HIV-infected and uninfected women with CIN3+ had a similar prevalence of other members of the HPV16-related alpha-9 oncHPV clade as a group (odds ratio, 1.02; 95 percent confidence interval, 0.53 to 1.94).


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For HIV-seropositive versus HIV-seronegative women with CIN3+, the prevalence of non-alpha-9 oncHPV types was increased (odds ratio, 3.9; 95 percent confidence interval, 1.3 to 11.8).

“This is consistent with prior reports that HIV has a weak effect on infection by HPV16 relative to other oncHPV and supports use of nonavalent HPV vaccine in HIV-seropositive women,” the authors write.

Two authors disclosed financial ties to the biopharmaceutical industry.

Reference

1. Massad LS, Xie X, Burk RD, et al. Association of cervical precancer with human papillomavirus types other than 16 among HIV co-infected women. Am J Obstet Gynecol. 2016;214:354.e1-6.