FDA: Drug Interactions Section Updated for Prezcobix

The labeling for Prezcobix (darunavir/cobicistat; Janssen) has been updated with new drug interactions data. 

Prezcobix, a combination of an HIV-1 protease inhibitor and a CYP3A inhibitor, is indicated to treat HIV-1 infection in adults. 

Under the Drug Interactions section, the following updates have been made:

• Prednisone has been added as an alternative corticosteroid to consider for co-administration with Prezcobix especially for long-term use
• Dose recommendations for HMG-CoA reductase inhibitors: daily doses for atorvastatin and rosuvastatin should not exceed 20mg. 
• When coadministering Prezcobix with drospirenone (hormonal contraceptive), clinical monitoring is recommended due to potential for hyperkalemia.
• Concomitant administration with ticagrelor, a platelet aggregation inhibitor, is not recommended. 

In addition, clinically relevant interactions have not been observed or are not anticipated with concomitant use of rilpivirine, dolutegravir, raltegravir, abacavir, emtricitabine, emtricitabine/tenofovir alafenamide, tenofovir DF, lamivudine, stavudine, zidovudine, or acid modifying medications (eg, antacids, H₂-receptor antagonists, proton pump inhibitors).

Prezcobix is available as 800mg/150mg strength tablets in 30-count bottles.

Reference

Prezcobix® [package insert]. Beerse, Belgium: Janseen; 2016.

This article originally appeared on MPR