HealthDay News — HIV resistance to the antiretroviral drug tenofovir (Viread) is common, according to a study published online in The Lancet Infectious Diseases.
Investigators looked at 1,926 patients with HIV from 36 countries with treatment failure between 1998 and 2015.
Tenofovir-resistant HIV strains were found in 57% of patients in sub-Sahara Africa. The researchers also noted that, of 700 individuals with tenofovir resistance, 83% had cytosine analogue resistance (M184V/I mutation), 78 percent had major non-nucleotide reverse-transcriptase inhibitor resistance, and 65 percent had both.
“Tenofovir is a critical part of our armamentarium against HIV, so it is extremely concerning to see such a high level of resistance to this drug,” study author Ravindra Gupta, MD, PhD, from the department of infection and immunity at University College London, said in a university news release. “It is very potent drug with few side effects, and there aren’t any good alternatives that can be deployed using a public health approach. Tenofovir is used not only to treat HIV but also to prevent it in high-risk groups, so we urgently need to do more to combat the problem of emerging resistance.”
Several authors disclosed financial ties to the pharmaceutical industry.
1. TenoRes Study Group. Global epidemiology of drug resistance after failure of WHO recommended first-line regimens for adult HIV-1 infection: a multicentre retrospective cohort study. Lancet Infect Dis J. 2016; DOI: http://dx.doi.org/10.1016/S1473-3099(15)00536-8.