HealthDay News — For adults with HIV, major depressive disorder (MDD) is associated with an increased risk of acute myocardial infarction (AMI), according to a study published online in JAMA Cardiology.
Tasneem Khambaty, PhD, from the University of Miami in Coral Gables, and colleagues examined whether depressive disorders are associated with incident AMI in a cohort of 26,144 veterans with HIV and cardiovascular disease (CVD). At baseline, 19% of veterans had MDD and 9% had dysthymic disorder.
The researchers noted that there were 490 AMI events (1.9%) during 5.8 years of follow-up. After adjustment for demographics, CVD risk factors, and HIV-specific factors, baseline MDD correlated with incident AMI (hazard ratios, 1.31 [95% confidence interval (CI), 1.05 to 1.62], 1.29 [95% CI, 1.04 to 1.60], and 1.30 [95% CI, 1.05 to 1.62], respectively). The associations were attenuated after further adjustment for hepatitis C, renal disease, substance abuse, and hemoglobin level (hazard ratio, 1.25; 95% CI, 1.00 to 1.56) and antidepressant use (hazard ratio, 1.12; 95% CI, 0.87 to 1.42). There was no correlation for baseline dysthymic disorder with incident AMI.
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“Our findings raise the possibility that MDD may be independently associated with incident atherosclerotic CVD in the HIV-infected population,” the authors write.
One of the researchers reported receiving grants and/or other forms of funding from Merck & Co, Bristol-Myers Squibb, Theratechnologies, and Gilead Sciences. Another researchers reported receiving grants from Gilead and AbbVie.
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