Mycoses

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Global Epidemiology of Fungal Keratitis and Its Outcomes

By

Bradley van Paridon

Investigators analyzed data collected over more than 70 years to estimate the annual global incidence of this severe corneal infection.

Ibrexafungerp Gets Priority Review for Vulvovaginal Candidiasis

By

Brian Park, PharmD

The FDA has accepted for filing and granted Priority Review to the NDA for ibrexafungerp (SCY-078; Scynexis) for the treatment of vulvovaginal candidiasis.

Antifungal Prophylaxis in Hematological Disease or Hematopoietic Stem Cell Transplantation

By

Bradley van Paridon

Investigators summarized the evidence on the efficacy and adverse effects of antifungal agents in patients with hematological disease or undergoing hematopoietic stem cell transplantation.

Increased Risk of Mycobacterial Infection With Immune Checkpoint Inhibitors

By

Christina Bennett, MS

Using FAERS, study researchers identified reported cases of tuberculosis and atypical mycobacterial infection in patients who received ICIs.

Invasive Aspergillosis Superinfection Possible in Symptomatic COVID-19

By

Zahra Masoud

Critically ill patients hospitalized with COVID-19 — particularly those who develop ARDS — may also experience an opportunistic aspergillosis superinfection.

Terbinafine, Fluconazole, and Itraconazole for Dermatophyte Toenail Onychomycosis

By

Brandon May

A novel study used network meta-analysis to compare pulse and continuous systemic therapies for toenail onychomycosis.

Generic Version of Antifungal Drug Mycamine Now Available

By

Brian Park, PharmD

Fresenius Kabi announced the launch of Micafungin for Injection, a generic version of Mycamine (micafungin for injection; Astellas Pharma).

Value of Persistently Negative (1,3)-β-D-Glucan in Adults With Candidemia

By

Bradley van Paridon

Adults with candidemia and persistently negative (1,3)-β-D-glucan tests present with a better prognosis than comparative groups.

Inhaled Itraconazole Fast-Tracked for Allergic Bronchopulmonary Aspergillosis in Asthma

By

Brian Park, PharmD

The FDA has granted Fast Track designation to PUR1900 for the treatment of allergic bronchopulmonary aspergillosis in patients with asthma.

Investigations of Pan-Resistant C auris Cases After Antifungal Treatment

By

Bradley van Paridon

The Centers for Disease Control and Prevention (CDC) summarized investigations into 3 cases of pan-resistant Candida auris infections in New York.

Injectable Micafungin Approved for Invasive Candidiasis in Younger Patients

By

Brian Park, PharmD

The FDA has approved the sNDA for Mycamine for the treatment of candidemia, acute disseminated candidiasis, Candida peritonitis and abscesses without meningoencephalitis and/or ocular dissemination in pediatric patients aged <4 months.

Oral Ibrexafungerp Effective in Vulvovaginal Candidiasis Trial

By

Brian Park, PharmD

Scynexis announced positive topline results from the phase 3 VANISH 303 trial of ibrexafungerp for the treatment of vulvovaginal candidiasis (VVC) in women.

Higher Frequency of C albicans After Root Canals in Patients With Type 2 Diabetes

By

Bradley van Paridon

Patients with a long-term history of type 2 diabetes mellitus (T2DM) carried Candida albicans in their dental root canals more frequently when they have a primary endodontic infection.

Aspergillosis, ABPA-Related Hospitalizations in Cystic Fibrosis Confer Worse Outcomes

By

Heidi Moore

Nearly one-third of patients with cystic fibrosis-related hospitalizations have aspergillosis, which is associated with worse outcomes.

Oral Amphotericin B Formulation Gets Orphan Drug Status for Cryptococcosis

By

Brian Park, PharmD

The Food and Drug Administration (FDA) has granted Orphan Drug designation to MAT2203 (Matinas BioPharma) for the treatment of cryptococcosis.

Novel Antifungal Gains Fast Track Designation for Seven Indications

By

Steve Duffy

The FDA has granted Fast Track designations to both the oral and intravenous formulations of fosmanogepix for 7 antifungal indications.

ATS Guideline Outlines Lab Tests for Diagnosis of Fungal Infections

Guideline addresses lab testing for diagnosis of fungal infections in pulmonary medicine, critical care

Key for Candida auris Prevention: Strict Adherence to Infection Control Measures

By

Sweta Gupta

Multidrug-resistant Candida auris is an urgent antimicrobial resistance threat and the key method of prevention is strict adherence to infection control measures.

Invasive Aspergillosis and Mucromycosis Diagnosed With Real-Time PCR

By

Zahra Masoud

A new real-time polymerase chain reaction assay shows promise in the noninvasive diagnosis of aspergillosis and mucormycosis.

T2Candida Diagnostic Test for ICU Patients at Risk for Invasive Candidiasis

By

Infectious Disease Advisor Contributing Writer

The combination of the new test T2Candida and blood culture seemed to have the best performance in the detection of invasive candidiasis.