Asymptomatic C diff Associated With Pathogen Reservoir, Affecting Carriers, Patients, Employees in ICU
Genomically-confirmed assessments of the risk for CDI found that asymptomatic carriers serve as viral reservoirs in clinical settings.
Nosocomial Infections
Nosocomial Infections
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Legionnaires’ Disease-Associated Hospitalizations Spiked Between 2006 and 2010
Research results underscore the importance of understanding the characteristics of Legionnaires’ disease and the need for early diagnosis.
GII.4 Genotype Most Common in Sporadic Pediatric Acute Gastroenteritis
Children with GII.4 type norovirus had more severe symptoms and required more medical care.
Guideline Update: Revised Consensus for Vancomycin Dosing and Monitoring in Serious MRSA Infection
Four medical societies have come together to publish an updated consensus guideline on dosing and monitoring vancomycin for the treatment of serious MRSA infections.
Strategic Guidelines for Managing Community-Acquired Pneumonia in Immunocompromised Populations Developed
In immunocompromised adults, community-acquired pneumonia should be treated by a multidisciplinary team of physicians.
Daptomycin Alone and in Combination for Complicated MRSA Bacteremia
Treatment with daptomycin for bacteremia caused by methicillin-resistant Staphylococcus aureus complicated by septic pulmonary emboli was found to have a success rate comparable to daptomycin-ceftaroline fosamil.
Mylan Recalls One Lot of Daptomycin for Injection
According to Mylan, the administration of the recalled product may lead to “serious adverse events including, but not limited to, local irritation, vasculitis/phlebitis, antigenic or allergic reactions, and microvascular obstruction, including pulmonary embolism.”
Methotrexate-Induced Acute Kidney Injuries in Patients with Hematologic Malignancies
Upon starting methotrexate treatment, LDH and albumin levels may be signals for AKIs in patients with hematologic malignancies.
Study Finds Vancomycin Increased Risk for Cytomegalovirus Reactivation After Hematopoietic Cell Transplant
A retrospective study of CMV-seropositive adults receiving allogeneic HCT and CMV-seronegative HLA-matched sibling donors found that vancomycin exposure before HCT increased the risk for CMV reactivation.
Bezlotoxumab Effective for Reducing Clostridioides difficile Recurrence
A post hoc analysis was conducted to assess the efficacy of bezlotoxumab in a subgroup of participants from the MODIFY I and II trials.
Strategies for Safe Home-Based Outpatient Parenteral Antimicrobial Therapy
An interactive, in-person barrier identification and mitigation tool can ensure safe administration of home-based outpatient parenteral antimicrobial therapy.
Recarbrio Noninferior to Pip/Tazo for Hospital-Acquired, Ventilator-Associated Bacterial Pneumonia
Merck announced results from the phase 3 RESTORE-IMI 2 trial of imipenem/relebactam/cilastatin (Recarbrio™) for the treatment of adults with hospital-acquired or ventilator-associated bacterial pneumonia (HABP/VABP).
Infection Prevention Is Widely Practiced Across Veterans Affairs Hospitals
Veterans Affairs hospitals adopted more infection prevention practices than non-VA hospitals.
Hand-Hygiene Adherence Varies at Critical Points of Care
Healthcare workers were more likely to partake in hand-hygiene protocols after contaminating tasks vs critical tasks and before such tasks.
Increased Rate of Bacterial Infection Hospitalizations With Substance Use Disorder
Rates of hospitalizations for serious bacterial infections among people with substance use disease are increasing, especially in younger populations.
Most Risk Factors for Prosthetic Joint Infection Treatment Nonresponse Hard to Modify
Eradication of prosthetic hip and knee joint infections is challenging, with failure rates >20% even in the setting of complete prosthesis removal.
Social Risk Factors Associated With Post-Colectomy Surgical Site Infections
Infection prevention programs targeting low-income groups undergoing colectomy may be important in reducing surgical site infections.
Antimicrobial Resistance Patterns Examined for Adult, Pediatric HAIs
Recent reports present updated summaries of common pathogens and antimicrobial resistance patterns among health care-associated infections.
Predicting Mortality After Transvenous Lead Extraction for Implantable Device Infections
The rate of complications and in-hospital mortality was found to be high in patients undergoing transcutaneous lead extraction for implantable device-related infections.
Trends in Rates of Hospitalized Infections Among Adults With Diabetes vs Those Without
There is a need to improve infectious risk mitigation in adults with diabetes because they are hospitalized for infections between 2.6 and 15.7 times as often as adults without diabetes, depending on the type of infection.
Carbapenem Nonsusceptible GNB Linked to In-Hospital Mortality
Among individuals with acute myelogenous leukemia (AML), carbapenem-nonsusceptible gram-negative bacteremia (GNB) is associated with worse outcomes than carbapenem-susceptible GNB.
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