Nosocomial Infections

Latest News

APEKS-NP: Cefiderocol Non-Inferior to Meropenem for Nosocomial, Gram-Negative Pneumonia

By

Bradley van Paridon

Researchers compared the efficacy and safety of cefiderocol vs high-dose, extended-infusion meropenem for adults with nosocomial pneumonia.

Risk Factors and Epidemiology of Carbapenemase-Producing Enterobacteriaceae in High-Risk Patients

By

Bradley van Paridon

Investigators assessed the risk factors, prevalence, and epidemiology of carbapenemase-producing Enterobacteriacea in high-risk patients from ICU and HSCT wards.

Futility Concerns Halt C difficile Vaccine Trial

By

Bradley van Paridon

The efficacy, immunogenicity, and safety of a Clostridioides difficile toxoid vaccine candidate was assessed.

Nosocomial Spread of COVID-19 Minimal With Rigorous Infection Control Measures

By

Sweta Gupta

Findings from a study published in JAMA Network Open suggest that rigorous infection control measures may be associated with minimized risk and provide reassurance to patients concerned about contracting COVID-19 in hospitals.

Infection Risk Low in Patients With PJI and Concomitant Asymptomatic Prosthetic Implants

By

Sweta Gupta

There is a low incidence of second PJI in patients with bacteremia or hematogenous periprosthetic joint infection with concomitant prosthetic implants.

Oral Antibiotic Therapy the Day Before Colon Surgery Reduces Incidence of Surgical-Site Infections

By

Brandon May

The use of prophylactic oral antibiotic in the day prior to elective colon surgery is associated with a reduced incidence of surgical-site infections.

Redefining the Cutoff Duration for Staphylococcus aureus Persistent Bacteremia

By

Sweta Gupta

Investigators assessed patients who hospitalized with microbial S aureus bacteremia to determine the most meaningful cutoff point to define S aureus persistent bacteremia.

S aureus Bloodstream Infection Linked to Risk for Myocardial Infarction

By

Bradley van Paridon

Investigators analyzed a potential link between community-acquired Staphylococcus aureus bloodstream infection and increased short-term risk for myocardial infarction, which is associated with subsequent mortality.

Number of Antibiotics Used, Neoplasia History Associated With Recurrent C diff Infection

By

Bradley van Paridon

Patients who received more than 3 types of antibiotics in the year prior to C diff onset were more likely to experience a reoccurrence of C diff infection.

Asymptomatic C diff Associated With Pathogen Reservoir, Affecting Carriers, Patients, Employees in ICU

By

Bradley van Paridon

Genomically-confirmed assessments of the risk for CDI found that asymptomatic carriers serve as viral reservoirs in clinical settings.

Legionnaires’ Disease-Associated Hospitalizations Spiked Between 2006 and 2010

By

Sweta Gupta

Research results underscore the importance of understanding the characteristics of Legionnaires’ disease and the need for early diagnosis.

GII.4 Genotype Most Common in Sporadic Pediatric Acute Gastroenteritis

By

Bradley van Paridon

Children with GII.4 type norovirus had more severe symptoms and required more medical care.

Guideline Update: Revised Consensus for Vancomycin Dosing and Monitoring in Serious MRSA Infection

By

Bradley van Paridon

Four medical societies have come together to publish an updated consensus guideline on dosing and monitoring vancomycin for the treatment of serious MRSA infections.

Strategic Guidelines for Managing Community-Acquired Pneumonia in Immunocompromised Populations Developed

By

Zahra Masoud

In immunocompromised adults, community-acquired pneumonia should be treated by a multidisciplinary team of physicians.

Daptomycin Alone and in Combination for Complicated MRSA Bacteremia

By

Bradley van Paridon

Treatment with daptomycin for bacteremia caused by methicillin-resistant Staphylococcus aureus complicated by septic pulmonary emboli was found to have a success rate comparable to daptomycin-ceftaroline fosamil.

Mylan Recalls One Lot of Daptomycin for Injection

By

Brian Park, PharmD

According to Mylan, the administration of the recalled product may lead to “serious adverse events including, but not limited to, local irritation, vasculitis/phlebitis, antigenic or allergic reactions, and microvascular obstruction, including pulmonary embolism.”

Methotrexate-Induced Acute Kidney Injuries in Patients with Hematologic Malignancies

By

Rita Aghjayan

Upon starting methotrexate treatment, LDH and albumin levels may be signals for AKIs in patients with hematologic malignancies.

Study Finds Vancomycin Increased Risk for Cytomegalovirus Reactivation After Hematopoietic Cell Transplant

By

Jessica Nye, PhD

A retrospective study of CMV-seropositive adults receiving allogeneic HCT and CMV-seronegative HLA-matched sibling donors found that vancomycin exposure before HCT increased the risk for CMV reactivation.

Bezlotoxumab Effective for Reducing Clostridioides difficile Recurrence

By

Zahra Masoud

A post hoc analysis was conducted to assess the efficacy of bezlotoxumab in a subgroup of participants from the MODIFY I and II trials.

Strategies for Safe Home-Based Outpatient Parenteral Antimicrobial Therapy

By

Sweta Gupta

An interactive, in-person barrier identification and mitigation tool can ensure safe administration of home-based outpatient parenteral antimicrobial therapy.