Nosocomial Infections

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Predictors of Multidrug-Resistant and Extended-Spectrum β-lactamase Gram-Negative Infections in Lung Transplant Recipients

By

Estie Mermelstein, MSN, FNP-BC

Researchers assessed the incidence and associated predictors of multidrug-resistant extended-spectrum and β-lactamase Gram-negative bacterial infection in bilateral lung transplant recipients.

Echinocandins Recommended as Optimal First-Line Treatment for Invasive Candidiasis

By

Maria Arini Lopez, PT, DPT, CSCS, CMTPT

Researchers evaluated the safety and efficacy of several antifungal agents for the treatment of invasive candidiasis infection.

Clinical Utility of Metal Nanoparticle Solutions Against Multidrug-Resistant Pathogens

By

Jessica Nye, PhD

Researchers evaluated the antimicrobial activity of metal nanoparticles against several multidrug-resistant pathogens.

Loop Drainage Technique May Become Gold Standard for Abscess Tx

By

Lauren Biscaldi

The loop drainage technique is less invasive than the conventional method because it requires 2 smaller incisions rather than 1 large incision with no packing of the wound.

Mortality Increased for Carbapenem-Resistant Infections Diagnosed via Blood Cultures

By

Estie Mermelstein, MSN, FNP-BC

Investigators assessed factors associated with 90- and 365-day mortality among veterans infected carbapenem-resistant Acinetobacter baumanii and carbapenem-resistant Pseudonomas aeruginosa.

Meropenem Treatment via Intermittent Bolus vs Extended Infusion in Critically ill Children

By

Jessica Nye, PhD

Researchers assessed clinical outcomes among critically ill children who received meropenem treatment via extended infusion vs intermittent bolus.

Monkeypox Poses Challenges, Even in High-Income Countries

Human monkeypox poses unique challenges, according to a retrospective observational study published online.

Antibiotics for Less Than 24 Hours After Orthopedic Surgery Prevents Health Care-Associated Infections

By

Colby Stong

Researchers assessed the effects of discontinuing antimicrobial prophylaxis within 24- vs 48-hours of clean orthopedic surgery for the prevention of health care-associated infections.

Gram Stain-Guided Antibiotics: Effective, May Combat Spread of Multidrug-Resistant Pathogens

By

Bradley van Paridon

Researchers compared the effect of Gram stain-guided antibiotics with guideline-based antibiotics for the treatment of patients with ventilator-associated pneumonia.

The Use of Rifampin for Periprosthetic Joint Infection Following Total Joint Arthroplasty

By

Shannon Storms

Researchers conducted a meta-analysis that assessed the use of rifampin among patients who developed periprosthetic joint infection following total joint arthoplasty.

Analysis of Burkholderia cepacia Outbreak From Contaminated Extracorporeal Membrane Oxygenation Water Heaters

By

Jessica Nye, PhD

Researchers conducted a study to evaluate a cluster of Burkholderia cepacia complex infections attributed to contaminated extracorporeal membrane oxygenation water heaters.

Attributable vs Crude Mortality in Candida Bloodstream Infections

By

Jessica Nye, PhD

Researchers conducted a study that assessed the rate of 90-day all-cause crude mortality vs attributable mortality among patients with candida bloodstream infections.

Analysis of the Global Burden of Bacterial Antimicrobial Resistance in 2019

By

Shannon Storms

Researchers conducted a systematic analysis to assess the global burden of antimicrobial resistance (AMR) and to estimate the number of deaths associated with or attributable to AMR in 2019.

Does Chlorhexidine Cleansing Decrease the Risk for Neonatal Healthcare-Associated Infections?

By

Shannon Storms

Researchers conducted a meta-analysis to determine whether chlorhexidine cleansing effectively decreases the risk for healthcare-associated infections in neonates.

Effect of High-Dose Rifampin in Staphylococcus Aureus Orthopedic Implant-Associated Infections

By

Bradley van Paridon

Researchers conducted a study to assess the effect of high-dose rifampin for the treatment of Staphylococcus aureus orthopedic implant-associated infection.

Association Between Double-Dose Cefuroxime and Surgical Site Infection Risk

By

Shannon Storms

Researchers conducted a study to determine whether a double-dose of cefuroxime decreases the risk for surgical site infections in patients weighing at least 80 kg.

Novel Outbreak Detection System That Combines Whole-Genome Sequencing, Machine Learning Shows Promise

By

Jessica Nye, PhD

Researchers sought to determine whether a novel system that combines whole-genome sequencing and machine learning is effective for detecting infectious outbreaks and identifying transmission routes of bacterial pathogens.

Safety and Risks Associated With Midline vs Peripherally Inserted Central Catheters

By

Bradley van Paridon

Researchers conducted a study to compare outcomes among patients who underwent placement of either a midline or peripherally inserted central catheter due to either difficult vascular access or to receive antibiotic therapy.

Effect of Chlorhexidine Gluconate Bathing on Vancomycin-Resistant Enterococci Transmission

By

Estie Mermelstein, MSN, FNP-BC

Investigators assessed whether daily bathing with 2% chlorhexidine gluconate decreases the risk for vancomycin-resistant enterococci (VRE) transmission in an intensive care unit with increased VRE endemicity.

Safety, Efficacy of Aminoglycosides or Polymyxin Monotherapy for Complicated UTI

By

Bradley van Paridon

Researchers conducted a study to assess the safety and efficacy of aminoglycosides or polymyxin monotherapy for the treatment of adults with complicated urinary tract infections caused by extensively drug-resistant Pseudomonas aeruginosa.