Pertussis Booster Dose Safe in Pediatric Patients With IBD

intramuscular pediatric vaccination
intramuscular pediatric vaccination
A booster dose of pertussis vaccine is safe and immunogenic for pediatric patients with inflammatory bowel disease.

For pediatric patients with inflammatory bowel disease (IBD), a booster dose of pertussis vaccine was safe and immunogenic. Findings from the study are published in Inflammatory Bowel Diseases.

A team of Polish researchers conducted a multicenter, prospective, controlled trial that included 138 patients aged 11-18 years with no history of pertussis booster immunization after age 6 or history of pertussis. They aimed to compare the immunogenicity among pediatric patients with IBD vs healthy controls.

Study patients were grouped into 1 of the following: patients with IBD receiving no immunosuppressive therapy (Group 1), those on thiopurines only (Group 2), those on thiopurines and TNF-α agents (Group 3), and healthy controls (Group 4). The control group and patients were given 1 dose of pertussis vaccine via intramuscular injection and were asked to record adverse effects for 3 days post-vaccination. 

The study’s primary outcome measure was adequate vaccine response, defined as the concentration of anti-Bordetella pertussis antibodies >11 mcg/mL assessed between 4-8 weeks post-vaccination.

The data showed no difference in the rates of adequate vaccine response between the 4 study groups (=.11). Patients with IBD taking immunosuppressive therapy did not differ from those not taking immunosuppressive therapy (90.6% vs 88.2%; =.37). Moreover, there were no serious adverse effects related to vaccine administration.

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Banaszkiewicz A, Gawronska A, Klincewicz B, et al. Immunogenicity of pertussis booster vaccination in children and adolescents with inflammatory bowel disease: a controlled study. Inflamm Bowel Dis. 2017; 23:847-852. doi: 10.1097/MIB.0000000000001076

This article originally appeared on MPR