HealthDay News — From 2005 to 2015 there was a decrease in the proportion of infants aged ≤60 days with a urinary tract infection (UTI) who received 4 or more days of intravenous (IV) antibiotics, according to a study published in Pediatrics.

William W. Lewis-de los Angeles, MD, from Ann & Robert H. Lurie Children’s Hospital of Chicago, and colleagues analyzed data from the Pediatric Health Information System database from 2005 through 2015 for infants aged ≤60 days old diagnosed with a UTI who were admitted to a children’s hospital and received IV antibiotics.

The researchers found that from 2005 to 2015 there was a decrease in the proportion of infants ≤60 days old receiving 4 or more days of IV antibiotics (long IV treatment) from 50% to 19%. 

There was variation in the proportion of infants aged ≤60 days receiving long IV treatment at 46 children’s hospitals from 3% to 59%; this was not associated with readmission (correlation coefficient, 0.13; P =.37). Readmission for a UTI was associated with younger age and female sex in multivariable analysis but not with duration of IV antibiotic therapy (adjusted odds ratio for long IV treatment, 0.93; 95% confidence interval, 0.52 to 1.67)

“These findings support the safety of short-course IV antibiotic therapy for appropriately selected neonates,” the authors write.

One author disclosed ties to Merck.

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Lewis-de Los Angeles WW, Thurm C, Hersh AL, et al. Trends in intravenous antibiotic duration for urinary tract infections in young infants [published online November 2, 2017]. Pediatrics. doi: 10.1542/peds.2017-1021.