Acute Respiratory Infections Reduced in Patients Receiving GERD Treatment

gastroesophageal reflux disease
gastroesophageal reflux disease
First study to examine the benefit of treating GERD with proton pump inhibitors in reducing the acute respiratory infections complications.

Treatment with proton pump inhibitors (PPIs) may help decrease healthcare visits for acute respiratory infections (ARIs) in patients with gastroesophageal reflux disease (GERD). These are the findings of a new study published in PLOS One.

Increasing epidemiological evidence suggests a strong relationship between gastroesophageal reflux episodes and respiratory symptoms. In this study, researchers aimed to assess whether treatment with PPIs had an impact on subsequent healthcare utilization for ARIs. This population-based study included 21,486 patients diagnosed with GERD and 21,486 matched comparison patients without GERD.

During the 1-year period before and after the index date, annual ARI episodes were compared between the patient groups. To estimate the adjusted association between GERD treatment and subsequent annual ARI rate, multiple regression analysis using a difference-in-difference approach was used.

Among GERD patients, the mean annual ARI episode dropped significantly by 11.4%, from 4.39 (during the year before PPI treatment) to 3.89 (after treatment with a PPI) (mean change = –0.5 visit; 95% CI –0.64 to –0.36). Poisson regression analysis also showed that GERD treatment was independently linked to a significant reduction in annual ARI rate (P <.001).

More studies are needed to validate these findings, as this is the first study to examine the benefit of PPI-treated GERD in reducing ARI complications. However, the authors note that “the study suggests that GERD treatment with PPIs may help reduce healthcare visits for ARIs, highlighting the importance of treatment-seeking by GERD patients and compliance with treatment.”

Related Articles


Lin HC, Xirasagar S, Chung SD, Huang CC, Tsai MC, Chen CH. Fewer acute respiratory infection episodes among patients receiving treatment for gastroesophageal reflux disease [published online February 21, 2017]. PLoS One. doi: 10.1371/journal.pone.0172436

This article originally appeared on MPR