Diagnosing coinfection in pneumonia can be challenging because of timing of the sample collection and false-negative results when the viruses replicate in the lower respiratory tract.
Pediatric HIV infection and HIV exposure without infection both had an association with carriage prevalence and densities for Streptococcus pneumoniae and Pneumocystis jirovecii.
Trimethoprim-sulfamethoxazole (TMP-SMX) for Pneumocystis jirovecii pneumonia (PCP) prophylaxis in combination with methotrexate (MTX) was shown to be successful and well-tolerated in patients with chronic inflammatory/autoimmune diseases.
Merck announced results from the phase 3 RESTORE-IMI 2 trial of imipenem/relebactam/cilastatin (Recarbrio™) for the treatment of adults with hospital-acquired or ventilator-associated bacterial pneumonia (HABP/VABP).
A parsimonious score system that accurately identified elderly and non-elderly patients with pneumonia at highest risk for mortality in the intensive care unit has been developed.
The FDA has accepted for review a sNDA for Recarbrio™, to treat adult patients with hospital-acquired and ventilator-associated bacterial pneumonia.
Inhaled amikacin adjunctive to standard-of-care intravenous antibiotic therapy was not associated with improvements in survival in mechanically ventilated patients with Gram-negative pneumonia.
Microbiologic treatment failure was found to be independently associated with recurrent pneumonia or death among patients with bacterial pneumonia after clinical cure.
Data gathered from a meta-analysis of clinical practice guidelines published in the European Journal of Clinical Microbiology and Infectious Diseases, show that well-designed randomized controlled trials are urgently needed.
Exposure to carbapenem and carboxypenicillin or ureidopenicillin during the week before onset of ventilator-associated pneumonia and the severity of disease with regard to respiratory and hematologic failures were independent risk factors for the occurrence of Stenotrophomonas maltophilia-related VAP.
The objective surveillance for nonventilator hospital-acquired pneumonia (HAP) via electronically computable definitions generates incidence, mortality, and adjusted odds ratios [OR] for hospital mortality similar to those generated by manual surveillance.
The decision to update the pneumococcal vaccine recommendations was based on a review of evidence that demonstrated that the implementation of the 2014 recommendation had minimal impact on PCV13-type disease at the population level among older adults.
