Researchers compared HAdV-3 with HAdV-7 replication kinetics and host response in ex vivo human lung tissue cultures.
For patients with heart failure, influenza and pneumococcal vaccinations are associated with lower in-hospital mortality.
The aim of this study was to evaluate the invasive disease potential of non-PCV13 serotypes after implementation of this vaccine.
The ODYSSEY study is evaluating the efficacy and safety of tradipitant in adults with neurogenic inflammation of the lung secondary to COVID-19 infection.
The U.S. Centers for Disease Control and Prevention informed employees that office space it rents in the Atlanta area would be closed after Legionella, the bacteria that causes legionnaires disease, was found in the buildings.
ICD-9 organism-specific administrative codes for pneumonia appear to underestimate the prevalence of specific disease-associated pathogens in hospitalized patients.
Researchers found limited clinical variability between PIV serotypes and substantial overlap in presenting signs and symptoms for PIV and other etiologies.
Research results underscore the importance of understanding the characteristics of Legionnaires’ disease and the need for early diagnosis.
A phase 3 study of tocilizumab (Actemra®) for the treatment of hospitalized patients with severe COVID-19 pneumonia did not meet its primary and key secondary end points.
In immunocompromised adults, community-acquired pneumonia should be treated by a multidisciplinary team of physicians.
Treatment with mavrilimumab is associated with improved clinical outcomes compared with standard care in non-mechanically ventilated patients with severe COVID-19 pneumonia and systemic hyperinflammation.
Preliminary data demonstrated that the Unyvero HPN panel was strongly concordant with bacterial culture for organism targets, confirming all pathogens reported by culture in 31 out of 35 patient samples.
Pediatric HIV infection and HIV exposure without infection both had an association with carriage prevalence and densities for Streptococcus pneumoniae and Pneumocystis jirovecii.
Trimethoprim-sulfamethoxazole (TMP-SMX) for Pneumocystis jirovecii pneumonia (PCP) prophylaxis in combination with methotrexate (MTX) was shown to be successful and well-tolerated in patients with chronic inflammatory/autoimmune diseases.
Merck announced results from the phase 3 RESTORE-IMI 2 trial of imipenem/relebactam/cilastatin (Recarbrio™) for the treatment of adults with hospital-acquired or ventilator-associated bacterial pneumonia (HABP/VABP).
A parsimonious score system that accurately identified elderly and non-elderly patients with pneumonia at highest risk for mortality in the intensive care unit has been developed.
Pfizer announced topline data from one of its phase 3 studies for 20vPnC for the prevention of invasive disease and pneumonia.
Anti-methicillin-resistant Staphylococcus aureus (MRSA) therapy in addition to standard pneumonia therapy does not improve mortality.
The FDA has accepted for review a sNDA for Recarbrio™, to treat adult patients with hospital-acquired and ventilator-associated bacterial pneumonia.
The FDA has requested that all manufacturers of bacitracin for injection voluntarily withdraw their product from the market.