Diagnosing coinfection in pneumonia can be challenging because of timing of the sample collection and false-negative results when the viruses replicate in the lower respiratory tract.
Pneumococcal colonization rates are low in recipients of solid organ transplants, but most of the colonizing serotypes are not included in pneumococcal vaccines.
The FDA has approved Xenleta (lefamulin; Nabriva Therapeutics) for the treatment of adults with community-acquired bacterial pneumonia (CABP) caused by the following susceptible microorganisms: Streptococcus pneumoniae, Staphylococcus aureus (methicillin-susceptible isolates), Haemophilus influenzae, Legionella pneumophila, Mycoplasma pneumoniae, and Chlamydophila pneumoniae.
Mycoplasma pneumoniae immunoglobulin M antibody-secreting cells were successfully used to differentiate between those with M pneumoniae infection and carriers in a pediatric population.
Patients with diabetes are at higher risk for hospitalization and mortality because of pneumococcal infection; however, uptake of vaccination remains suboptimal.
The PCV-13 demonstrated an association with the detection of low-density colonization and resulted in vaccine efficacy against colonization acquisition.
Hospitalized patients with alcohol use disorder (AUD) and community-acquired pneumonia harbor resistant organisms less often than hospitalized patients with community-acquired pneumonia (CAP) without AUD, according to a study published in JAMA Network Open. In addition, researchers noted that the higher age-adjusted mortality risk seen in patients with AUD appears to a result of differences in comorbidities,…
Compared with patients who have CSPA pneumonia, patients with CRPA pneumonia were more likely to be men and admitted from skilled nursing facilities and more often require mechanical ventilation.
Combinations of ibuprofen with aztreonam and ceftazidime display synergistic antimicrobial activity against drug-resistant Pseudomonas aeruginosa isolates in vitro, and efficacy of ceftazidime combined with ibuprofen was shown in vivo in a murine P aeruginosa pneumonia model, according to research presented at American Society of Microbiology (ASM) Microbe 2019 held from June 20-24, 2019 in San Francisco, California. Approximately…
The sNDA is supported by data from the phase 3, double blind, DEFINE-CABP trial (N=860) which compared the safety and efficacy of Baxdela to moxifloxacin for the treatment of CABP.
In patients with community-onset pneumonia, the Drug-Resistance in Pneumonia (DRIP) score was better at guiding appropriate broad-spectrum antibiotic use compared with the Healthcare Associated Pneumonia (HCAP) criteria.
Performing therapeutic bronchoscopy at the time of intensive care unit admission may decrease ventilator-associated pneumonia incidence in patients with level I trauma.
Based on the 2016 International Working Group (IWG) diagnostic criteria for idiopathic pulmonary fibrosis (IPF), outcomes are relatively similar between patients with IPF with pneumonia and patients with an acute IPF exacerbation.
Approaches to emergency department community-acquired pneumonia care can incorporate either guideline-based serial clinical assessment or procalcitonin-driven strategies.
The novel combination antibacterial agent ceftolozane/tazobactam had comparable clinical and microbiologic response rates to meropenem in treating gram-negative nosocomial pneumonia.
