Exebacase Gains Breakthrough Therapy Status for MRSA Bacteremia, Including Right-Sided Endocarditis
Exebacase is a novel, recombinantly-produced lysin (cell wall hydrolase enzyme), that targets the peptidoglycan cell wall.
Sepsis
Sepsis
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New Guidelines Issued for Cases of Pediatric Sepsis
For many PICO questions, the literature review failed to identify sufficient data to develop strong recommendations for children with septic shock or other sepsis-associated organ dysfunction.
Intestinal Microbiota Composition and Bloodstream Infection in Stem Cell Transplant Recipients
Among recipients of allogeneic hematopoietic cell transplantation (allo-HCT), gram-negative intestinal colonization is highly predictive of bloodstream infections.
Vitamin C, Hydrocortisone, Thiamine Not Superior to Hydrocortisone Alone for Septic Shock
For patients with septic shock, treatment with intravenous vitamin C, hydrocortisone, and thiamine did not significantly improve the duration of survival and free of vasopressor administration over 7 days.
Sepsis Incidence Underestimated, Remains Major Health Burden Worldwide
Results of a study are the first to produce global estimates of sepsis incidence and mortality across 195 countries and territories, 282 underlying causes of death, both sexes, and 23 age groups for the years 1990 to 2017.
Sepsis-Associated Mortality Rates Have Improved in Patients With Cancer
From 2003 to 2014, sepsis-associated mortality rates significantly declined in patients with cancer, yet these rates have remained relatively unchanged in patients without cancer.
Digital Sepsis Monitoring May Improve Inpatient Outcomes
A digital sepsis alert presents opportunity to improve care for patients who may have sepsis.
Incidence of Bloodstream Infections Lower in Recurrent CDI With Fecal Transplant
Patients with recurrent Clostridioides difficile infection (CDI) were less likely to develop bloodstream infections (BSI) if treated with fecal microbiota transplantation (FMT) compared with antibiotics.
Is Receiving Early Fluid Resuscitation Safe in Sepsis With Comorbidities?
Early fluid resuscitative efforts are important in patients with sepsis with cirrhosis, congestive heart failure, or end-stage renal disease to prevent acute respiratory failure.
Early Infectious Diseases Consult May Lower Sepsis Mortality
Early infectious diseases consultation is associated with a reduction in in-hospital mortality for patients receiving a severe sepsis and septic shock treatment bundle.
No Link Found Between Per-Hour Delay in Antibiotics and Mortality in Septic Shock
In this study, we found that early first antibiotic administration was associated with improved outcomes in ED patients with septic shock using propensity score analysis.
Quality Indicators Improve Management of Staphylococcus aureus Bacteremia
The development of quality indicators and accompanying defining conditions may highlight areas of improvement at hospital sites to enhance the management of Staphylococcus aureus bacteremia.
Can Vitamin C Infusion Reduce Organ Failure in Sepsis and ARDS?
Among patients with sepsis and acute respiratory distress syndrome, administration of high-dose vitamin C via intravenous infusion does not significantly reduce organ failure.
Staphylococcus aureus Bacteremia: Outcomes of Infection From Biliary Source
The involvement of the biliary tract in bacteremia caused by Staphylococcus aureus may be more likely to develop in certain patients and aggressive treatment should be considered.
Survey of Bloodstream Infections After Six Types of Solid Organ Transplant
Bloodstream infections are common in patients who have received a solid organ transplants.
Studies Further Support Shorter Antibiotic Courses in Gram-Negative Bacteremia
A shorter course of antibiotic treatment for uncomplicated gram-negative bloodstream infections appears to be as effective as long-course antibiotic treatment.
Cardiac Implantable Electronic Device-Related Infective Endocarditis Outcomes
Cardiac implantable electronic device-related infective endocarditis is diagnosed in a third of patients with implantable device related infections.
Initiating Empirical Treatment for Sepsis Reduces Blood Culture Sensitivity
When empirical antimicrobial therapy is initiated in patients with severe manifestations of sepsis, the sensitivity of blood cultures drawn shortly after treatment initiation is reduced.
Persistent Inflammation After Sepsis Linked With Higher Mortality
About two-thirds of patients who survive hospitalization for sepsis have persistent elevation of inflammation and immunosuppression biomarker.
High Prevalence of Infective Endocarditis in E faecalis Bacteremia
Data published in the Journal of the American College of Cardiology showed a high prevalence of definite infective endocarditis (IE) in patients with Enterococcus faecalis bacteremia (26%), suggesting that echocardiography should be considered in patients with E faecalis infection. A multicenter study using echocardiography was conducted from January 2014 to December 2016 in 344 consecutive…
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