For many PICO questions, the literature review failed to identify sufficient data to develop strong recommendations for children with septic shock or other sepsis-associated organ dysfunction.
Among recipients of allogeneic hematopoietic cell transplantation (allo-HCT), gram-negative intestinal colonization is highly predictive of bloodstream infections.
For patients with septic shock, treatment with intravenous vitamin C, hydrocortisone, and thiamine did not significantly improve the duration of survival and free of vasopressor administration over 7 days.
Results of a study are the first to produce global estimates of sepsis incidence and mortality across 195 countries and territories, 282 underlying causes of death, both sexes, and 23 age groups for the years 1990 to 2017.
From 2003 to 2014, sepsis-associated mortality rates significantly declined in patients with cancer, yet these rates have remained relatively unchanged in patients without cancer.
Patients with recurrent Clostridioides difficile infection (CDI) were less likely to develop bloodstream infections (BSI) if treated with fecal microbiota transplantation (FMT) compared with antibiotics.
Early fluid resuscitative efforts are important in patients with sepsis with cirrhosis, congestive heart failure, or end-stage renal disease to prevent acute respiratory failure.
Early infectious diseases consultation is associated with a reduction in in-hospital mortality for patients receiving a severe sepsis and septic shock treatment bundle.
In this study, we found that early first antibiotic administration was associated with improved outcomes in ED patients with septic shock using propensity score analysis.
The development of quality indicators and accompanying defining conditions may highlight areas of improvement at hospital sites to enhance the management of Staphylococcus aureus bacteremia.
Among patients with sepsis and acute respiratory distress syndrome, administration of high-dose vitamin C via intravenous infusion does not significantly reduce organ failure.
The involvement of the biliary tract in bacteremia caused by Staphylococcus aureus may be more likely to develop in certain patients and aggressive treatment should be considered.
A shorter course of antibiotic treatment for uncomplicated gram-negative bloodstream infections appears to be as effective as long-course antibiotic treatment.
When empirical antimicrobial therapy is initiated in patients with severe manifestations of sepsis, the sensitivity of blood cultures drawn shortly after treatment initiation is reduced.
Data published in the Journal of the American College of Cardiology showed a high prevalence of definite infective endocarditis (IE) in patients with Enterococcus faecalis bacteremia (26%), suggesting that echocardiography should be considered in patients with E faecalis infection. A multicenter study using echocardiography was conducted from January 2014 to December 2016 in 344 consecutive…
The updated 1-hour sepsis care bundle is based on 2016 guidelines and recommends a specific set of treatments that should begin within 1 hour of sepsis recognition.
