Skin infections

When to Suspect GBS Cellulitis and Necrotizing Fasciitis in Infants

GBS infections in infants, cellulitis and necrotizing fasciitis, although uncommon in infants, requires swift treatment with antibiotics and occasionally surgical debridement.

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The Cleveland Clinic notes that 3D printing “gives medical practitioners the ability to provide patients the most advanced care, while simultaneously minimizing the risk of complication in patients that meet specific medical requirements.” Using this technology, medical devices can be matched to exact patient specifications. 3D printing can be used to improve the lives of patients reliant on prosthetic limbs, replace human organ transplants, and speed up surgical procedures. In all its applications, 3D printing is “increasing the attention to detail in patient care.”2

Most Risk Factors for Prosthetic Joint Infection Treatment Nonresponse Hard to Modify

Bradley van Paridon

Eradication of prosthetic hip and knee joint infections is challenging, with failure rates >20% even in the setting of complete prosthesis removal.

Risk of stroke after herpes zoster in patients with autoimmune diseases

Varicella Strain Identity in First and Second Herpes Zoster Infection Episodes

Bradley van Paridon

Varicella zoster virus (VZV) is extremely stable during the varicella replication phase and subsequent establishment of latency in sensory ganglia throughout the body.

Social Risk Factors Associated With Post-Colectomy Surgical Site Infections

Zahra Masoud

Infection prevention programs targeting low-income groups undergoing colectomy may be important in reducing surgical site infections.

Risk for Skin Infections, Diabetes Increase With Statin Use

Study shows mechanism of statins can induce onset of diabetes

Update on Efficacy of Treatments for Cutaneous Candidiasis

Linda Peckel

A review finds that fluconazole is the only commercially available evidence-based option for systemic treatment of cutaneous candidiasis.

Molluscum contagiosum occurs in approximately 5% to 18% of HIV-infected people, but is becoming rare in areas of the world with good access to highly effective antiretroviral therapies (HAART).16 It is caused by an infection of the epidermal keratinocytes by the molluscum contagiosum virus, a double-stranded DNA virus belonging to the Poxviridae family.16,17 Patients present with small (≤5 mm in diameter), raised lesions that are usually white, pink, or flesh colored with a dimple or pit in the center.17 The lesions are typically smooth, firm, and pearly appearing, and can affect any area of the body, although they are rarely found on the palms or soles. They may occur as solitary lesions or in groups and typically resolve within 6 to 12 months without any scarring.17 Genital lesions may take longer to resolve, and healing times up to 4 years have been reported.16,17 Photo Credit: Medical Images RM/AL LAMME.

Berdazimer Sodium Plus Hydrogel Provides Rapid Lesion Clearance in Molluscum Contagiosum

Brandon May

SB206 12% represents a well-tolerated topical treatment for molluscum contagiosum that can be applied at home by patients or caregivers, solving an unmet medical need.

DAIR Linked With High Readmission/Deep Surgical Site Infection of Prosthetic Joints

Sweta Gupta

Polymicrobial prosthetic joint infections managed with surgical debridement, antibiotics and implant retention (DAIR) had high readmission rates and deep surgical site infections.

Length of Hospital Stay Improved With Dalbavancin Therapy in ABSSSI

Nicole Clemons

Length of stay for ABSSSI hospital admissions were significantly improved after implementing dalbavancin therapy with the ENHANCE ABSSSI trial.

Once-Daily Omadacycline Noninferior to Twice-Daily Linezolid for ABSSSI in Adults

Sweta Gupta

Once-daily oral omadacycline was noninferior to twice-daily oral linezolid in adults with acute bacterial skin and skin structure infections.

Ceftaroline Approved for Younger Patients to Treat Acute Bacterial Skin/Skin Structure Infections

Diana Ernst, RPh

The FDA has expanded the indication for Teflaro to include treatment of ABSSSI in pediatric patients from birth to less than 2 months of age.

16S rDNA PCR Improves Bacterial Pyomyositis Diagnosis

Zahra Masoud

Using a broad-range PCR technique targeting 16S ribosomal DNA may improve diagnosis and treatment of bacterial pyomyositis.

Deep Surgical Site Infection After Knee Fracture Repair

Zahra Masoud

Orthopedic surgeons should be vigilant when managing periarticular knee fracture repairs.

Staphylococcus aureus Colonization Associated With Food Sensitization and Allergy, Not Eczema Severity

Brandon May

The association of S aureus with food sensitization and allergy could influence interventions aimed at inducing and maintaining tolerance to food allergens in eczematous infants.

Bacteremia Risk in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Infectious Disease Advisor Contributing Writer

Prediction of sepsis via markers such as hypothermia and elevated procalcitonin may allow for its early detection and management.

Five Cases of Vibrio vulnificus Necrotizing Fasciitis Outside Traditional Risk Areas

Sweta Gupta

Researchers describe 5 cases of Vibrio vulnificus necrotizing fasciitis that occurred after water or shellfish exposure in the Delaware Bay.

Atopic dermatitis (an allergy-related skin disorder) with secondary infection on a patient's wrist.

Methotrexate, Cyclosporine Yield Lowest Infection Risk in Atopic Dermatitis

Infectious Disease Advisor Contributing Writer

Patients requiring systemic therapy for atopic dermatitis may benefit from lower infection risk treatments such as methotrexate, cyclosporine.

Ceftobiprole Activity Against Bacterial Skin and Soft Tissue Pathogens

Bradley van Paridon

Ceftobiprole was highly active against most clinical isolates of the major Gram-positive and Gram-negative skin and soft tissue infection pathogen groups.

Paromomycin Topical Cream Effective in Treating Cutaneous Leishmaniasis

Infectious Disease Advisor Contributing Writer

Topical therapy with a paromomycin-based cream offered an effective treatment for cutaneous leishmaniasis.

Comparison of Ivermectin and Permethrin for Scabies

Infectious Disease Advisor Contributing Writer

Investigators sought to determine whether the use of ivermectin in patients with scabies leads to improved clinical and safety outcomes compared with permethrin.

Seborrheic Dermatitis Higher in Men, Associated With Fungal, Bacterial Skin Diseases

Brandon May

Seborrheic dermatitis is more prevalent in men and older people and has an increased rate of dermatological comorbidity.

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