HealthDay News — The potassium-competitive acid blocker vonoprazan-based triple therapy seems safe and effective compared with conventional proton pump inhibitor (PPI)-based triple therapy as first-line treatment against Helicobacter pylori, according to a study published online in the Journal of Digestive Diseases.

Satoki Shichijo, MD, PhD, from the University of Tokyo, and colleagues performed a multicenter study involving 2715 patients who received first-line H pylori eradication therapy. Vonoprazan-based triple therapy was compared with conventional PPI-based triple therapy.

The researchers found that eradication rates were 87.2 and 72.4% for vonoprazan-based and conventional PPI-based therapy, respectively (P < 0.01). There were 10 cases of diarrhea, six of nausea/vomiting, and five of rash in the vonoprazan-based therapy group; these rates were not higher than those in the conventional PPI-based group.

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“Vonoprazan-based triple therapy is feasible; it showed a higher eradication rate than conventional PPIs as a first-line regimen,” the authors write.


1. Shichijo S, Hirata Y, Niikura R, et al. Vonoprazan versus conventional proton pump inhibitor-based triple therapy as first-line treatment against Helicobacter pylori: A multicenter retrospective study in clinical practice. J Digest Dis. 2016; doi: 10.1111/1751-2980.12398.