High-Risk HPV Infection Linked With Cardiovascular Disease in Women
In a large cohort of apparently healthy young and middle-aged women, high-risk HPV infection was significantly associated with an increased risk of developing CVD.
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SAN FRANCISCO — Women with high-risk, or oncogenic, human papillomavirus (HPV) infection are at higher risk for developing cardiovascular disease compared to women without high-risk HPV. This research was recently presented at IDWeek 2018 held October 3-7, 2018, in San Francisco, California.
This cohort study included 63,411 women, age >30 years, who did not have cardiovascular disease at study initiation, but who were tested for high-risk HPV infection and followed for 5 years to evaluate for subsequent onset of cardiovascular disease. Out of this cohort, 7.6% had high-risk HPV infection, and there were 1122 new cases of cardiovascular disease identified in 261,598.9 person-years of follow-up. Individuals with high-risk HPV infection were 1.26 times (95% CI, 1.03-1.53) more likely than those without high-risk HPV infection to have incident cardiovascular disease. The hazard ratio decreased to 1.25 (95% CI, 1.03-1.53) when further adjustments for potential confounders were made. Individuals with a body mass index (BMI) ≥25 kg/m2 were at higher risk than individuals with BMIs under this cutoff, but there were no other significant differences between subgroups.
The study researchers followed up with participants once per year or once every 2 years between 2011 and 2016. Links to the Health Insurance and Review Agency database were used to identify cardiovascular disease. Adjusted hazard ratios were approximated with a Cox-proportional hazards regression model, yielding 95% CI.
The study researchers concluded that “[in] this large cohort of apparently healthy young and middle-aged women, high-risk HPV infection was significantly associated with an increased risk of developing [cardiovascular diseases], indicating a possible role for high-risk HPV in the pathogenesis of [cardiovascular diseases].”
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Joo EJ, Kim J, Park SY, Cheong HS. High-risk human papillomavirus infection and the risk of cardiovascular disease: a cohort study. Poster presented at: Infectious Diseases Week; October 3-7, 2018; San Francisco, CA. Abstract 2509.