IDWeek 2018

Delafloxacin Equally Effective as Vancomycin/Aztreonam for Acute Bacterial, Skin Suture Infections

Delafloxacin Equally Effective as Vancomycin/Aztreonam for Acute Bacterial, Skin Suture Infections

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Treatment with intravenous and oral delafloxacin, a fluoroquinolone antibiotic with gram-negative and gram-positive activity, was comparable to vancomycin/aztreonam in improving clinical signs and symptoms in acute bacterial and skin structure infections.

Glecaprevir/Pibrentasvir Is Safe, Efficacious for HCV/HIV-1 Coinfection

Glecaprevir/Pibrentasvir Is Safe, Efficacious for HCV/HIV-1 Coinfection

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Analysis of 2 phase 3 clinical trials evaluating the safety/efficacy of glecaprevir/pibrentasvir in people with HCV coinfected with HIV-1 found an overall sustained virologic response of 98% at week 12 of treatment in those with or without cirrhosis.

Once Daily Single-Tablet HIV Regimen Safe and Effective

Once Daily Single-Tablet HIV Regimen Safe and Effective

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Once-daily single-tablet regimen of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in adults who have virologic suppression of HIV-1 infection has a high efficacy and safety profile.

Antibiotic Prophylaxis Before Dental Procedures May Be Unnecessary

Antibiotic Prophylaxis Before Dental Procedures May Be Unnecessary

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Prophylactic antibiotic prescriptions before dental procedures may not be limited to indicated cardiac diagnoses, as per present guidelines, according to a study presented at IDWeek 2018 in San Francisco.

Cure Rate of Intra-Abdominal Infection With Short vs Prolonged Therapy

Cure Rate of Intra-Abdominal Infection With Short vs Prolonged Therapy

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No significant differences in clinical cure rates were observed between short-course and prolonged-course antimicrobial therapy in patients with intraabdominal infections.

PCV13 in Young Adults With Diabetes Could Avert Pneumonia Hospitalizations

PCV13 in Young Adults With Diabetes Could Avert Pneumonia Hospitalizations

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PCV13 in adults age <65 years with diabetes could reduce a substantial number of pneumonia hospitalizations.

Sustained Hepatitis C Treatment Associated With Lower Risk for Cardiovascular Events

Sustained Hepatitis C Treatment Associated With Lower Risk for Cardiovascular Events

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Treatment for hepatitis C is associated with a reduction in cardiovascular events.

Common Antiretrovirals Have Same Likelihood of Certain Disorders After Initiation

Common Antiretrovirals Have Same Likelihood of Certain Disorders After Initiation

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Incidence of body fat redistribution/accumulation, pancreatic disorders, musculoskeletal disorders, IRIS, severe systemic rash, and HSR did not differ among common prescribed antiretrovirals.

Probiotic Use May Not Protect Against <i>Clostridium Difficile</i> Infection

Probiotic Use May Not Protect Against Clostridium Difficile Infection

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In patients taking multiple antibiotics, proton pump inhibitors, or histamine receptor antagonists, the concurrent use of probiotics was associated with an increased incidence of Clostridium difficile infection

Vitamin D Deficiency Associated With Sepsis Mortality

Vitamin D Deficiency Associated With Sepsis Mortality

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Vitamin D deficiency is associated with increased risk for sepsis mortality in postmenopausal women, which was seen in all ages.

Fluoroquinolones May Aid in Reducing Mortality in Community-Acquired Pneumonia

Fluoroquinolones May Aid in Reducing Mortality in Community-Acquired Pneumonia

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For patients with CAP, antibiotic regimens including a fluoroquinolone may reduce mortality risk by 1-2% compared to beta-lactams and cephalosporins alone.

Statins May Decrease the Risk for Active Tuberculosis

Statins May Decrease the Risk for Active Tuberculosis

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The use of statins may decrease the risk for active tuberculosis.

Daptomycin Plus Fosfomycin More Effective Than Daptomycin Monotherapy in MRSA Bacteremia

Daptomycin Plus Fosfomycin More Effective Than Daptomycin Monotherapy in MRSA Bacteremia

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The combination of daptomycin with fosfomycin demonstrates increased efficacy in treating methicillin-resistant Staphylococcus aureus bacteremia compared with daptomycin alone.

A Single Combination Tablet Suppresses HIV Load Through 48 Weeks

A Single Combination Tablet Suppresses HIV Load Through 48 Weeks

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A combination single tablet once-a-day regimen of doravirine/lamivudine/tenofovir disoproxil fumarate demonstrated non-inferiority and no significant adverse events when compared with continuation of established antiretroviral therapy in adults infected with HIV-1.

Continued Noninferiority of Doravirine to Efavirenz at Week 96

Continued Noninferiority of Doravirine to Efavirenz at Week 96

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The week 96 results of the DRIVE-AHEAD phase 3 noninferiority trial support noninferiority of doravirine to efavirenz in treatment-naive adults with HIV-1.

Antibiotic Stewardship May Aid Stepdown Therapies for Community-Acquired Pneumonia

Antibiotic Stewardship May Aid Stepdown Therapies for Community-Acquired Pneumonia

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The use of fluoroquinolones in stable patients with community-acquired pneumonia can be reduced with stewardship programs that share antibiotic use data and provide guidance for step-down therapy.

In Utero Antiretroviral Exposure Associated With Higher Neurological Risk

In Utero Antiretroviral Exposure Associated With Higher Neurological Risk

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Children who are HIV-exposed, but uninfected, demonstrated a higher risk of adverse neurologic events during infancy and early childhood associated with ART exposure in-utero.

Improved Documentation May Help Distinguish Beta-Lactam Allergy vs Intolerance

Improved Documentation May Help Distinguish Beta-Lactam Allergy vs Intolerance

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A documented β -lactam allergy was found in more than one-third of patients receiving broad-spectrum antibiotics, however, only 10% of patients were found to be truly allergic.

High Susceptibility Antibiotics Reduce Readmission Rates for Urinary Tract Infections

High Susceptibility Antibiotics Reduce Readmission Rates for Urinary Tract Infections

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The use of a moderate to low susceptibility antibiotic to treat a urinary tract infection [UTI] may result in a 1.74-fold increase in the odds of an emergency department readmission within 30 days for another UTI.

Voriconazole Therapy Associated With Hallucinations, Confusion

Voriconazole Therapy Associated With Hallucinations, Confusion

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Patients receiving voriconazole for the treatment of invasive fungal infections experienced CNS side effects that often resolved after decreasing/discontinuing this therapy.

Oral Ciprofloxacin Effective in Treatment for Bacteremia

Oral Ciprofloxacin Effective in Treatment for Bacteremia

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Oral ciprofloxacin has been found to be an effective option for gram-negative bacteremia treatment.

IDWeek 2018: What to Look For

IDWeek 2018: What to Look For

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San Francisco takes center stage in the world of infectious diseases from October 3 to 7, as the Moscone Centre hosts IDWeek 2018.

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