Abnormal Platelet Aggregation Studies
Acquired causes of platelet dysfunction:
Ingestion of aspirin or aspirin-like compounds or NSAIDs
Impaired renal function
Exposure to cardiopulmonary bypass
Presence of a paraprotein
Congenital causes of platelet dysfunction:
Storage pool disease
Disorders of thromboxane production or action
Suggested Additional Lab Testing
Platelet aggregation studies with characteristic response patterns for the different agonists help identify Glanzmann thrombasthenia, Bernard-Soulier disease, aspirin ingestion, and defects in thromboxane production or action.
Plasma or serum BUN and creatinine and urinalysis to assess renal function should be ordered.
If aspirin ingestion is suspected but denied by patient, measurement of salicylates (metabolites of aspirin) may prove useful.
Bone marrow biopsy may be useful if myeloproliferative disease is suspected.
Serum protein electrophoresis can reveal a paraprotein. To identify platelet granule storage pool disease, assays for the granular contents of platelets can be performed, but these are complex, costly, and rarely performed.
Copyright © 2017, 2013 Decision Support in Medicine, LLC. All rights reserved.
No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. The Licensed Content is the property of and copyrighted by DSM.
Sign Up for Free e-newsletters
Infectious Disease Advisor Articles
- Dundee Severity Classification Improves Management of Patients With Cellulitis
- Three New Ebola Vaccines Demonstrate Persistent Immune Response
- Isavuconazole Not Noninferior to Caspofungin for Invasive Candida Infections
- Pregnant Women Commonly Refuse Vaccines
- Tap Water in Neti Pot Linked to Death From Brain-Eating Amoeba
- HIV Seroconversion Despite PrEP Therapy
- Management of Mycobacterium chimaera Outbreak From Heater-Cooler Units
- Novel H pylori Eradication Therapy Effective in Phase 3 Trial
- Topical 15% Paromomycin-Aquaphilic Effective For New World Leishmaniasis
- FDA: Safe to Eat Romaine Lettuce Again, but Check Labels
- Prenatal Malaria Exposure Modulates Innate Immune Responses at Birth
- Best Approach to Reduce Surgical Site Infections Before Colorectal Surgery
- A Single Triple-Drug Treatment for Lymphatic Filariasis
- Cyclosporiasis Cases Markedly Higher in 2018 Than Previous 2 Years
- Mail-Based HPV Testing May Increase Access