Malaria

CYP2D6 Enzymatic Activity May Increase Primaquine Malaria Treatment Efficacy

CYP2D6 Enzymatic Activity May Increase Primaquine Malaria Treatment Efficacy

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A natural variability of genotype-determined, CYP2D6-dependent metabolism of primaquine phosphate is associated with an increased risk of failure in the treatment of P vivax malaria.

Short Course Primaquine Regimens for <i>P vivax</i> Malaria Improves Treatment Efficacy

Short Course Primaquine Regimens for P vivax Malaria Improves Treatment Efficacy

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Chloroquine with either 7- or 14-day primaquine regimens provided highly effective radical cure of vivax malaria on the Thailand-Myanmar border.

Permethrin Plus Pyriproxyfen-Treated Bednets Reduce Malaria Transmission

Permethrin Plus Pyriproxyfen-Treated Bednets Reduce Malaria Transmission

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Long-lasting insecticidal nets treated with permethrin plus pyriproxyfen are more effective in preventing clinical malaria compared with standard insecticidal nets.

Novel Malaria Vaccine Shows Activity Only at Peak Titers

Novel Malaria Vaccine Shows Activity Only at Peak Titers

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A malaria transmission-blocking vaccine, Pfs25H-EPA in Alhydrogel®, was well tolerated and safe and induced significant blockage of parasite transmission, but this activity was only seen at peak titers after 4 vaccine doses.

FDA Advisory Committee Votes in Favor of Tafenoquine for Malaria Prevention

FDA Advisory Committee Votes in Favor of Tafenoquine for Malaria Prevention

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In clinical trials, tafenoquine, an 8-aminoquinoline, demonstrated efficacy against 2 primary types of malaria, Plasmodium vivax and P. falciparum malaria.

Single-Dose Krintafel Approved for the Radical Cure of <i>P vivax</i> Malaria

Single-Dose Krintafel Approved for the Radical Cure of P vivax Malaria

The FDA approved Krintafel for the radical cure of Plasmodium vivax malaria in patients ≥16 years old who are receiving appropriate antimalarial therapy for acute P vivax infection.

Promising Early Results With P27A Candidate Vaccine for Malaria Prevention

Promising Early Results With P27A Candidate Vaccine for Malaria Prevention

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Early findings show that the P27A candidate vaccine for malaria prevention appeared to be safe and induced a strong immunogenic response with parasite growth inhibitory capacity.

Vivax Malaria Relapses Predominantly Delayed by Chloroquine, Prevented by Primaquine

Vivax Malaria Relapses Predominantly Delayed by Chloroquine, Prevented by Primaquine

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The benefits of using slowly eliminated chloroquine vs rapidly eliminated arsenuate anti-malarials were assessed in a 3-way randomized comparison trial.

Long-Lasting Insecticidal Nets Improved Malaria Control Over Standard Methods

Long-Lasting Insecticidal Nets Improved Malaria Control Over Standard Methods

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As a direct consequence of this trial, WHO revised its policy on long-lasting insecticidal nets in September, 2017, gave interim endorsement to pyrethroid-piperonyl butoxide nets as a new WHO class of vector control product.

Despite Pyrethroid Resistance, Insecticidal Nets Protect Against Malaria

Despite Pyrethroid Resistance, Insecticidal Nets Protect Against Malaria

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In some locations, malaria incidence remained high despite high use of nets, emphasizing the need for new tools and approaches for malaria prevention if targets for the reduction of the global malaria burden are to be achieved.

CDC Recommends Additional Malaria Treatment Option During Pregnancy

CDC Recommends Additional Malaria Treatment Option During Pregnancy

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Women in the United States with uncomplicated malaria during the first trimester of pregnancy should be treated with the currently recommended options of either mefloquine or quinine plus clindamycin. However, when neither of these options is available, artemether-lumefantrine should be considered for treatment.

Malaria Therapy During Pregnancy Needs a Translational Booster

Malaria Therapy During Pregnancy Needs a Translational Booster

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First trimester treatment for malaria could change with the results of 1 of the most robust meta-analyses to date that compared artemisinin-based therapy vs quinine.

Inhaled Nitric Oxide Protects From Fine Motor Impairment in Severe Malaria

Inhaled Nitric Oxide Protects From Fine Motor Impairment in Severe Malaria

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As long-term neurocognitive deficits can occur as a result of severe malaria, researchers assessed the potential neuroprotective effect of inhaled nitric oxide on children with the infection.

Climate Change: Effects on the Incidence and Distribution of Infectious Diseases

Climate Change: Effects on the Incidence and Distribution of Infectious Diseases

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Without proactive measures and response, the changing climate is projected to continue to adversely affect the global incidence and distribution of infectious diseases and cause 250,000 additional deaths per year between 2030 and 2050.

FDA Grants Orphan Drug Designation for Novel Malaria Drug

FDA Grants Orphan Drug Designation for Novel Malaria Drug

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The FDA granted orphan drug designation to an investigational treatment for malaria.

Mass Drug Administration Can Reduce Short-term Malaria Transmission

Mass Drug Administration Can Reduce Short-term Malaria Transmission

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Mass drug administration has been proposed as a method to eradicate Plasmodium falciparum malaria.

Placental Malaria and Risk of Malaria Infection in Childhood

Placental Malaria and Risk of Malaria Infection in Childhood

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Placental malaria during pregnancy may raise the risk of malaria infection in childhood by promoting maternal microchimerism, in which the fetus acquires noninherited maternal cells during pregnancy. Maternal microchimerism may be the mechanism by which the fetus develops tolerance to malaria antigens, leading to an impaired malaria-specific immune response.

Investigational Malaria Vaccine Shows Durable Response to Multiple Strains

Investigational Malaria Vaccine Shows Durable Response to Multiple Strains

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3 IV doses of PfSPZ vaccine conferred protection after immunization against different Pf strains of malaria than the one the vaccine came from.

NIH Begins Study on a Universal Mosquito-Borne Diseases Vaccine

NIH Begins Study on a Universal Mosquito-Borne Diseases Vaccine

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Investigational vaccine is designed to trigger an immune response to mosquito saliva rather than to a specific virus or parasite carried by mosquitoes.

Antibody Therapy May Prevent Fatal Cerebral Malaria

Antibody Therapy May Prevent Fatal Cerebral Malaria

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In an animal model study, researchers tested an antibody therapy that may treat cerebral malaria.

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