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MEGACE ES
Anorexia/cachexia
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Drug Name:

MEGACE ES Rx

Generic Name and Formulations:
Megestrol acetate 125mg/mL; oral susp; lemon-lime flavor.

Company:
Endo Pharmaceuticals

Therapeutic Use:

Indications for MEGACE ES:

Anorexia, cachexia, or unexplained significant weight loss in patients diagnosed with AIDS.

Limitations Of use:

Should only be instituted after treatable causes of weight loss are sought and addressed. Not for prophylactic use to avoid weight loss.

Adult:

625mg/5mL per day.

Children:

Not established.

Contraindications:

Pregnancy.

Warnings/Precautions:

Do not substitute with other megestrol suspensions (not interchangeable). History of thromboembolic disease. Monitor for signs/symptoms of adrenal insufficiency; consider empiric therapy if occurs. Diabetes. Renal impairment. Elderly. Fetal toxicity. Obtain (–) pregnancy test prior to initiation. Advise females of reproductive potential to use effective contraception during therapy. Nursing mothers: not recommended.

Pharmacological Class:

Progestin.

Interactions:

May increase insulin requirements. Decreases indinavir levels.

Adverse Reactions:

Nausea, diarrhea, impotence, rash, flatulence, hypertension, asthenia; rare: adrenal insufficiency, breakthrough bleeding.

Generic Availability:

YES

How Supplied:

Concentrated susp (125mg/mL)—5oz

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