A recent microbiological surveillance study found that >10% of linens tested positive for the fungi Mucorales at 20% of the hospitals included in the study.
Anidulafungin, caspofungin, and micafungin have shown similar risk profiles for severe hepatotoxicity.
Arikayce is intended for oral inhalation use and is administered via the Lamira Nebulizer System only.
The Phase 3 ReSPECT prophylaxis trial of rezafungin in patients undergoing allogeneic bone marrow transplantation is anticipated to start in the first quarter of 2019.
Pediatric histoplasmosis most frequently manifests as pulmonary disease, and the highest diagnostic yields were achieved when multiple diagnostic modalities were used.
Influenza proved to be an independent risk factor for invasive pulmonary aspergillosis.
Screening of asymptomatic coccidioidomycosis within a Coccidioides-endemic area allowed for identifying and managing asymptomatic cases before patients began tumor necrosis factor-α inhibitor therapy.
Candidemia and Clostridium difficile infection (CDI) are both common healthcare-associated infections with overlapping risk factors, and almost 1 in 10 patients with candidemia are coinfected with CDI.
A novel nanodiagnostic panel may be helpful in reducing the length of empiric antifungal treatment in patients with multiple risk factors for candidemia.
Based on the findings, it was concluded that fluconazole use during pregnancy was not associated with significantly increased risks of stillbirth or neonatal death. However, the authors cautioned that the confidence intervals were wide and neither result was statistically significant.
Although rare even in high-risk groups, invasive aspergillosis is associated with high hospital mortality rates, excess duration of hospitalization, and a 40% relative increase in the odds of 30-day readmission.
Results support further development of NDV-3A vaccine and provide guidance for meaningful clinical endpoints for immunotherapeutic management of recurrent vulvovaginal candidiasis.
While immunocompromised patients are the most susceptible to CNS fungal infections, they can also occur in immunocompetent patients undergoing invasive procedures such as neurosurgery and in patients exposed to contaminated devices or drugs.
While isavuconazole is an important therapeutic option in the management of invasive fungal infections, the epidemiology and microbiology of breakthrough infections on this agent are not well understood.
SCY-078 is an investigational antifungal agent that is a semi-synthetic derivative of the natural product enfumafungin.
The Bruker Maldi system is already cleared for use in identifying 333 species or species groups, including 424 bacteria and yeast species.
The absence of availability of amphotericin B or in conditions in which amphotericin B cannot be administered safely, the oral combination of fluconazole plus flucytosine provides an effective and sustainable alternative.
Treatment of cryptococcal meningitis with two weeks of flucytosine and fluconazole was noninferior to two weeks of amphotericin B. Addition of flucytosine to amphotericin B was superior to amphotericin B plus fluconazole.
Researchers validated the clinical sensitivity of the T2Candida panel for the diagnosis of bloodstream infections caused by the 5 most common pathogenic Candida species.
In this systematic review and meta-analysis, patients with infective endocarditis with vegetations greater than 10mm in size had significantly increased risk of systemic embolism and mortality.
FDA posts a notification for a voluntarily recall of a diabetes drug over microbial contamination.
Six-month survival was better in patients who received liposomal amphotericin B-based monotherapy than in those receiving a candin-based monotherapy.
F901318 has potent in vitro activity against A flavus and is highly active in both in vitro and in vivo models mimicking invasive human disease.
Antimicrobial stewardship traditionally focuses on optimal use of antibacterial agents, not antifungal therapy.
Compared to blood cultures, T2 Candida Panel is faster and more sensitive in detecting Candidemia.
Rapid identification of Candida auris is crucial in order to implement appropriate precautions and avoid transmission to other patients.
Drs Tapper and Crum-Cianflone discuss aspergillosis, an emerging complication of severe influenza infections.
Researchers designed a case-control study using de-identified commercial health claim information in the United States from January 1, 2007, to December 31, 2009.
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