Mycoses

Many Linens Delivered To US Hospitals Contaminated With Mucorales Mold

Many Linens Delivered To US Hospitals Contaminated With Mucorales Mold

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A recent microbiological surveillance study found that >10% of linens tested positive for the fungi Mucorales at 20% of the hospitals included in the study.

Hepatotoxicity Risk Associated With Anidulafungin, Caspofungin, and Micafungin

Hepatotoxicity Risk Associated With Anidulafungin, Caspofungin, and Micafungin

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Anidulafungin, caspofungin, and micafungin have shown similar risk profiles for severe hepatotoxicity.

Amikacin Inhalation Suspension Approved for Mycobaterium Avium Infection

Amikacin Inhalation Suspension Approved for Mycobaterium Avium Infection

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Arikayce is intended for oral inhalation use and is administered via the Lamira Nebulizer System only.

Rezafungin Gets Fast Track, QIDP Status for Prevention of Invasive Fungal Infections

Rezafungin Gets Fast Track, QIDP Status for Prevention of Invasive Fungal Infections

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The Phase 3 ReSPECT prophylaxis trial of rezafungin in patients undergoing allogeneic bone marrow transplantation is anticipated to start in the first quarter of 2019.

Pediatric Histoplasmosis Most Frequently Manifested as Pulmonary Disease

Pediatric Histoplasmosis Most Frequently Manifested as Pulmonary Disease

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Pediatric histoplasmosis most frequently manifests as pulmonary disease, and the highest diagnostic yields were achieved when multiple diagnostic modalities were used.

Influenza an Independent Risk Factor for Invasive Pulmonary Aspergillosis

Influenza an Independent Risk Factor for Invasive Pulmonary Aspergillosis

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Influenza proved to be an independent risk factor for invasive pulmonary aspergillosis.

Coccidioidomycosis Screening Benefits TNFi Therapy Recipients

Coccidioidomycosis Screening Benefits TNFi Therapy Recipients

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Screening of asymptomatic coccidioidomycosis within a Coccidioides-endemic area allowed for identifying and managing asymptomatic cases before patients began tumor necrosis factor-α inhibitor therapy.

Candidemia and <i>Clostridium difficile</i> Coinfection Common in Certain High-Risk Groups

Candidemia and Clostridium difficile Coinfection Common in Certain High-Risk Groups

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Candidemia and Clostridium difficile infection (CDI) are both common healthcare-associated infections with overlapping risk factors, and almost 1 in 10 patients with candidemia are coinfected with CDI.

Novel Nanodiagnostic Panel May Reduce Empiric Antifungal Use in High-Risk Candidemia

Novel Nanodiagnostic Panel May Reduce Empiric Antifungal Use in High-Risk Candidemia

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A novel nanodiagnostic panel may be helpful in reducing the length of empiric antifungal treatment in patients with multiple risk factors for candidemia.

Antifungal Use During Pregnancy and Risk of Stillbirth: What's the Link?

Antifungal Use During Pregnancy and Risk of Stillbirth: What's the Link?

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Based on the findings, it was concluded that fluconazole use during pregnancy was not associated with significantly increased risks of stillbirth or neonatal death. However, the authors cautioned that the confidence intervals were wide and neither result was statistically significant.

Costs and Outcomes Associated With Invasive Aspergillosis Infections

Costs and Outcomes Associated With Invasive Aspergillosis Infections

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Although rare even in high-risk groups, invasive aspergillosis is associated with high hospital mortality rates, excess duration of hospitalization, and a 40% relative increase in the odds of 30-day readmission.

Study Supports Development of a Vaccine for Recurrent Vulvovaginal Candidiasis

Study Supports Development of a Vaccine for Recurrent Vulvovaginal Candidiasis

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Results support further development of NDV-3A vaccine and provide guidance for meaningful clinical endpoints for immunotherapeutic management of recurrent vulvovaginal candidiasis.

Fungal Infections of the CNS: Diagnostic and Treatment Approaches

Fungal Infections of the CNS: Diagnostic and Treatment Approaches

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While immunocompromised patients are the most susceptible to CNS fungal infections, they can also occur in immunocompetent patients undergoing invasive procedures such as neurosurgery and in patients exposed to contaminated devices or drugs.

Risk for Breakthrough Invasive Fungal Infections With Isavuconazole: More Data Needed

Risk for Breakthrough Invasive Fungal Infections With Isavuconazole: More Data Needed

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While isavuconazole is an important therapeutic option in the management of invasive fungal infections, the epidemiology and microbiology of breakthrough infections on this agent are not well understood.

First-in-Class Antifungal Fast-Tracked for Vulvovaginal Candidiasis

First-in-Class Antifungal Fast-Tracked for Vulvovaginal Candidiasis

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SCY-078 is an investigational antifungal agent that is a semi-synthetic derivative of the natural product enfumafungin.

First Test to Identify <i>Candida auris</i> Gets FDA Approval

First Test to Identify Candida auris Gets FDA Approval

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The Bruker Maldi system is already cleared for use in identifying 333 species or species groups, including 424 bacteria and yeast species.

Antifungal Combination Treatment for Cryptococcal Meningitis in HIV

Antifungal Combination Treatment for Cryptococcal Meningitis in HIV

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The absence of availability of amphotericin B or in conditions in which amphotericin B cannot be administered safely, the oral combination of fluconazole plus flucytosine provides an effective and sustainable alternative.

Flucytosine plus fluconazole is noninferior to amphotericin B in treating cryptococcal meningitis

Treatment of cryptococcal meningitis with two weeks of flucytosine and fluconazole was noninferior to two weeks of amphotericin B. Addition of flucytosine to amphotericin B was superior to amphotericin B plus fluconazole.

T2Candida May Shorten Time to <i>Candida</i> Detection, Species Identification

T2Candida May Shorten Time to Candida Detection, Species Identification

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Researchers validated the clinical sensitivity of the T2Candida panel for the diagnosis of bloodstream infections caused by the 5 most common pathogenic Candida species.

Vegetation Size May Increase Mortality Risk in Infective Endocarditis

Vegetation Size May Increase Mortality Risk in Infective Endocarditis

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In this systematic review and meta-analysis, patients with infective endocarditis with vegetations greater than 10mm in size had significantly increased risk of systemic embolism and mortality.

Possible Microbial Contamination Prompts Voluntary Recall of Diabetes Drug

Possible Microbial Contamination Prompts Voluntary Recall of Diabetes Drug

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FDA posts a notification for a voluntarily recall of a diabetes drug over microbial contamination.

Long-Term Outcomes Following Prosthetic Valve Endocarditis Caused by <i>Candida</i>

Long-Term Outcomes Following Prosthetic Valve Endocarditis Caused by Candida

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Six-month survival was better in patients who received liposomal amphotericin B-based monotherapy than in those receiving a candin-based monotherapy.

Novel Antifungal Agent for Treatment of <i>Aspergillus flavus</i> Infections

Novel Antifungal Agent for Treatment of Aspergillus flavus Infections

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F901318 has potent in vitro activity against A flavus and is highly active in both in vitro and in vivo models mimicking invasive human disease.

The T2Candida Panel Has Decreased Time to Therapy Initiation for Candidemia

The T2Candida Panel Has Decreased Time to Therapy Initiation for Candidemia

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Antimicrobial stewardship traditionally focuses on optimal use of antibacterial agents, not antifungal therapy.

T2 Candida Panel is Superior to Blood Cultures for Identifying Candidemia

T2 Candida Panel is Superior to Blood Cultures for Identifying Candidemia

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Compared to blood cultures, T2 Candida Panel is faster and more sensitive in detecting Candidemia.

<i>Candida auris</i>: Dispatch From an Outbreak

Candida auris: Dispatch From an Outbreak

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Rapid identification of Candida auris is crucial in order to implement appropriate precautions and avoid transmission to other patients.

Aspergillosis, An Emerging Complication of Severe Flu Infections

Aspergillosis, An Emerging Complication of Severe Flu Infections

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Drs Tapper and Crum-Cianflone discuss aspergillosis, an emerging complication of severe influenza infections.

TNF Inhibitors and Risk Factors for Fungal and Mycobacterial Infections

TNF Inhibitors and Risk Factors for Fungal and Mycobacterial Infections

Researchers designed a case-control study using de-identified commercial health claim information in the United States from January 1, 2007, to December 31, 2009.

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