Pediatric illnesses

Synovial Fluid Cell Counts Do Not Accurately Differentiate Arthritis Types

Synovial Fluid Cell Counts Do Not Accurately Differentiate Arthritis Types

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Accurate and rapid diagnostics methods are needed to inform initial clinical decision making for patients with hip monoarthritis.

Ventriculomegaly, Polymicrogyria Predict Epilepsy Risk Among Pediatric Patients With CMV Infections

Ventriculomegaly, Polymicrogyria Predict Epilepsy Risk Among Pediatric Patients With CMV Infections

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Investigators retrospectively reviewed the patients' medical records and MRI images and assessed the associations between the MRI findings and neurologic outcomes, specifically neurodevelopmental achievement, epilepsy, and sensorineural hearing loss.

MenACWY-TT Vaccine Can Be Effectively Coadministered With Routine Pediatric Immunizations

MenACWY-TT Vaccine Can Be Effectively Coadministered With Routine Pediatric Immunizations

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Study showed that DTPa-HBV-IPV/Hib and PHiD-CV coadministered with MenACWY-TT in infants and toddlers were immunogenic with an acceptable reactogenicity profile.

Effect of Pneumococcal Vaccination With PCV10 on All-Cause Acute Otitis Media

Effect of Pneumococcal Vaccination With PCV10 on All-Cause Acute Otitis Media

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In this whole-population study, researchers demonstrated a 22% vaccine effect of the 10-valent pneumococcal conjugate vaccine on all-cause acute otitis media.

UTICalc: A New Calculator for Estimating the Probability of UTI in Children

UTICalc: A New Calculator for Estimating the Probability of UTI in Children

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The UTICalc calculator can be used to guide testing and treatment in children with suspected urinary tract infection.

COPD Risk in Middle-Age: The 3-Way Interaction of Asthma, Smoking, and Measles

COPD Risk in Middle-Age: The 3-Way Interaction of Asthma, Smoking, and Measles

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A childhood measles infection may increase the risk for post-bronchodilator airflow obstruction in middle-age adults via its interaction with asthma and smoking.

FDA to Review Fluzone Quadrivalent 0.5mL Dose for Younger Patients

FDA to Review Fluzone Quadrivalent 0.5mL Dose for Younger Patients

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The sBLA included clinical data from a Phase 4 study that enrolled nearly 2000 children and assessed the safety and immunogenicity of the 0.5mL dose.

Season and Year of Birth an Emergent Risk Factor for Rotavirus

Season and Year of Birth an Emergent Risk Factor for Rotavirus

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Researchers found being born in an odd calendar year, especially in the winter or fall seasons, emerged as a risk factor for rotavirus in the postvaccine era in the United States.

Wide Range of Clinical Manifestations Identified in Chronic Recurrent Multifocal Osteomyelitis

Wide Range of Clinical Manifestations Identified in Chronic Recurrent Multifocal Osteomyelitis

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A series of reported cases shows that the range of associated clinical manifestations is heterogeneous in chronic nonbacterial osteomyelitis or chronic recurrent multifocal osteomyelitis.

Critical Need to Reduce Pediatric Prophylactic Antimicrobial Prescriptions Worldwide

Critical Need to Reduce Pediatric Prophylactic Antimicrobial Prescriptions Worldwide

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Cross-sectional survey represents the first assessment of antimicrobial prescription practices for prophylaxis in pediatric patients hospitalized worldwide.

MenB Vaccine Gets Breakthrough Therapy Designation for Children Ages 1-9 Years

MenB Vaccine Gets Breakthrough Therapy Designation for Children Ages 1-9 Years

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The FDA has granted Breakthrough Therapy designation to Trumenba for immunization caused by Neisseria meningitidis group B in children.

Prediction tool for urinary tract infections in preverbal children

The model developed accurately predicted which patients may need further testing based on clinical variables, and who may need antibiotics therapy based on urine analysis supplement.

Efficacy of Adjuvanted vs Conventional Quadrivalent Flu Vaccine Compared

Efficacy of Adjuvanted vs Conventional Quadrivalent Flu Vaccine Compared

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MF59 adjuvanted, quadrivalent influenza vaccine (aQIV) was found to be more efficacious in preventing influenza than a non-adjuvanted conventional influenza vaccine in children aged 6 through 23 months.

Herpes Zoster in Healthy Children Linked to Varicella-Zoster Vaccination

Herpes Zoster in Healthy Children Linked to Varicella-Zoster Vaccination

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The morphology of the lesions included erythematous papules, pseudovesicles, and plaques, with associated pain in 2 and pruritus in 3 patients; systemic symptoms ranged from none to low‐grade fevers, upper respiratory symptoms, and joint pain.

Risk Factors for Cytomegalovirus Reinfections in Seropositive Women

Risk Factors for Cytomegalovirus Reinfections in Seropositive Women

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Findings provide an alternative explanation for virus acquisition and shedding in seroimumne pregnant women that contrasts with proposed mechanisms that argue that reactivation of persistent infection in seroimmune women leads to infection and virus shedding.

Children With ASD, Younger Siblings Are Undervaccinated

Children With ASD, Younger Siblings Are Undervaccinated

Compared with the general population, children with autism spectrum disorder and their younger siblings are undervaccinated.

MenACWY-TT Vaccine Evaluated in Patients With Anatomic/Functional Asplenia

MenACWY-TT Vaccine Evaluated in Patients With Anatomic/Functional Asplenia

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Study evaluated the immunogenicity and safety of 1 and 2 doses of the quadrivalent meningococcal serogroups A, C, W, Y tetanus toxoid-conjugate vaccine in individuals with functional or anatomic asplenia.

Sepsis Calculator Reduces Antibiotic Therapy for Suspected Early-Onset Sepsis

Sepsis Calculator Reduces Antibiotic Therapy for Suspected Early-Onset Sepsis

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Implementation of the sepsis calculator in daily clinical decision-making may be feasible in conjunction with existing protocols, with high adherence.

Oseltamivir Does Not Increase Suicide Risk in Pediatric Population

Oseltamivir Does Not Increase Suicide Risk in Pediatric Population

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Use of oseltamivir does not appear to increase the risk of suicide in pediatric patients.

Compliance-linked incentives increase infant immunizations rates in rural India

Infantile immunization rates were higher among children whose caregivers received compliance-linked incentives when compared to those who received only mobile phone reminders and those who received no intervention.

Cystourethrograms Not Required For All Infant Urinary Tract Infections

Cystourethrograms Not Required For All Infant Urinary Tract Infections

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Investigators assessed the need for conducting routine voiding cystourethrograms in infants diagnosed with urinary tract infection.

Inhaled Nitric Oxide Protects From Fine Motor Impairment in Severe Malaria

Inhaled Nitric Oxide Protects From Fine Motor Impairment in Severe Malaria

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As long-term neurocognitive deficits can occur as a result of severe malaria, researchers assessed the potential neuroprotective effect of inhaled nitric oxide on children with the infection.

Planned Meta-Analysis of Risk Factors for Neonatal Pneumonia in India

Planned Meta-Analysis of Risk Factors for Neonatal Pneumonia in India

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This will be the first systematic review and meta-analysis on risk factors for pneumonia among neonates in India.

Oral neonatal rotavirus vaccine RV3-BB effective in preventing severe gastroenteritis

Newborns receiving the oral human neonatal rotavirus vaccine (RV3-BB) with the first dose occurring either at birth or at 8 weeks experienced fewer cases of severe rotavirus gastroenteritis than those treated with placebo.

Meningococcal Serogroup B Vaccine Safe, Effective Short-Term in Children, Adolescents

Meningococcal Serogroup B Vaccine Safe, Effective Short-Term in Children, Adolescents

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In the overall comparative meta-analyses, the multicomponent meningococcal serogroup B vaccine had increased immunogenicity (short-term and persistent) compared with recombinant meningococcal serogroup B vaccine against strain NZ98/254.

Shorter pediatric tuberculosis treatment linked to higher completion rates

Children with tuberculosis who received 3 months of directly observed preventative therapy were >25 times more likely to complete their treatment regimen than those who received 9 months of self-administered therapy.

Human Rhinovirus in Febrile Infants Does Not Alter UTI Risk

Human Rhinovirus in Febrile Infants Does Not Alter UTI Risk

Human rhinovirus is common in febrile infants, and detection does not alter risk of concomitant UTI.

Detection of respiratory viruses in febrile infants suggests lower risk of bacterial infection

Respiratory viruses were identified in 55% of febrile infants; those older than 28 days had a lower risk of bacterial infection when they tested positive for a respiratory virus.

Gastric Acid Inhibitors May Increase Late-Onset Sepsis Risk in Preterm Infants

Gastric Acid Inhibitors May Increase Late-Onset Sepsis Risk in Preterm Infants

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Study showed that very low birth weight infants exposed to gastric acid inhibitors have significantly increased odds of developing infections, and that the risk increases with each day of exposure.

Safety of Clofazimine in Treating Children With <i>Mycobacterium abscessus</i> Infections

Safety of Clofazimine in Treating Children With Mycobacterium abscessus Infections

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Clofazimine was safe and well-tolerated as part of a multidrug regimen for the treatment of children with Mycobacterium abscessus odontogenic infections.

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