Pneumonia

Planned Meta-Analysis of Risk Factors for Neonatal Pneumonia in India

Planned Meta-Analysis of Risk Factors for Neonatal Pneumonia in India

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This will be the first systematic review and meta-analysis on risk factors for pneumonia among neonates in India.

Higher Mortality Rate in Severe CAP Treated With Invasive Mechanical Ventilation

Higher Mortality Rate in Severe CAP Treated With Invasive Mechanical Ventilation

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Patients admitted to hospitals with severe CAP who subsequently required invasive mechanical ventilation had a higher mortality risk.

Increased Risk for Invasive Pneumococcal Disease With Opioid Use

Increased Risk for Invasive Pneumococcal Disease With Opioid Use

Opioid use is associated with elevated risk of invasive pneumococcal disease.

FDA: Avycaz Approved for Hospital-Acquired, Ventilator-Associated Pneumonia

FDA: Avycaz Approved for Hospital-Acquired, Ventilator-Associated Pneumonia

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The FDA has approved the use of Avycaz (ceftazidime, avibactam) to treat hospital-acquired bacterial pneumonia.

Trends of <i>S pneumoniae, H influenzae</i> Antibiotic Resistance in Children

Trends of S pneumoniae, H influenzae Antibiotic Resistance in Children

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Study analyzed the trends of nasopharyngeal carriage and antibiotic resistance of Streptococcus pneumoniae, Haemophilus influenza, and Moraxella catarrhalis isolated from young children with acute otitis media during a 16-year period.

PCV13 Vaccine Elicits Small, Transient Reduction in Pneumococcal Carriage in Adults

PCV13 Vaccine Elicits Small, Transient Reduction in Pneumococcal Carriage in Adults

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A single dose of PCV13 was found to be effective in generating a small, temporary reduction in vaccine-type nasopharyngeal pneumococcal carriage in older, community-dwelling residents.

Corticosteroids Associated With Reduced Pneumonia-Related Mortality

Corticosteroids Associated With Reduced Pneumonia-Related Mortality

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Corticosteroid therapy was associated with more adverse events, especially hyperglycemia, but the harms did not seem to outweigh the benefits.

Ceftazidime-Avibactam Efficacious in Nosocomial Pneumonia

Ceftazidime-Avibactam Efficacious in Nosocomial Pneumonia

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Results support a role for ceftazidime-avibactam as a potential alternative to carbapenems in patients with nosocomial pneumonia (including ventilator-associated pneumonia) caused by Gram-negative pathogens.

Reason for Hope: Promising Gram-Negative Infection Treatments in the Pipeline

Reason for Hope: Promising Gram-Negative Infection Treatments in the Pipeline

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Dr McKinnell provides a summary of drugs in development for infections caused by Gram-negative bacteria, including carbapenem-resistant Pseudomonas aeruginosa and carbapenem-resistant Enterobacteriaceae.

Nonventilator Hospital-Acquired Pneumonia Highly Prevalent in Acute Care

Nonventilator Hospital-Acquired Pneumonia Highly Prevalent in Acute Care

Nonventilator hospital-acquired pneumonia is a significant burden in US acute care hospitals and poses a risk to nonelderly, non-intensive unit patients.

Machine Learning Algorithms in Medicine: What Are the Pitfalls?

Machine Learning Algorithms in Medicine: What Are the Pitfalls?

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Experts discusses the potential pitfalls of machine learning algorithms in medicine.

Routine Chest Radiographs Not Recommended in Suspected Pediatric Pneumonia

Routine Chest Radiographs Not Recommended in Suspected Pediatric Pneumonia

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Chest X-rays do not differentiate between viral and bacterial pathogens, and they do not subsequently alter the course of treatment.

Breastfeeding Mediates Pneumonia Outcomes in HIV-Exposed Children

Breastfeeding Mediates Pneumonia Outcomes in HIV-Exposed Children

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Investigators evaluated pneumonia outcomes and HIV exposure with birth weight status, malnutrition, breast feeding, in utero exposure to combination antiretroviral therapy, or the severity of pneumonia.

Serological Response to PCV13, PPV23 Vaccination Varies According to Individual Biologic in RA

Serological Response to PCV13, PPV23 Vaccination Varies According to Individual Biologic in RA

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The objective of the study was to evaluate initial serologic responses to the 13-valent protein-conjugated and the 23-valent polysaccharide pneumococcal vaccine.

Primary Prophylaxis Reduces Pneumocystis Pneumonia in Rheumatic Disease

Primary Prophylaxis Reduces Pneumocystis Pneumonia in Rheumatic Disease

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Prolonged treatment with high-dose steroids is a significant risk factor for pneumocystis pneumonia in patients with hematologic malignancies, solid organ transplants, and rheumatic diseases.

Increased Aspiration Pneumonia Risk Associated With Antipsychotic Use

Increased Aspiration Pneumonia Risk Associated With Antipsychotic Use

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The absolute risk for aspiration pneumonia attributable to antipsychotic exposure is much greater in older rather than younger adults.

Tools for Predicting Prolonged Hospitalization in Pediatric CAP

Tools for Predicting Prolonged Hospitalization in Pediatric CAP

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Pleural fluid lactic dehydrogenase and glucose are useful parameters in determining the severity of pediatric CAP.

Reduced Rate of Ventilator-Associated Pneumonia With Nebulized Antibiotics

Reduced Rate of Ventilator-Associated Pneumonia With Nebulized Antibiotics

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Prophylactic antibiotics delivered by nebulization in patients who were mechanically ventilated reduced the rate of ventilator-associated pneumonia

Combination β-lactam, Macrolide Pneumonia Therapy in Children Not More Effective

Combination β-lactam, Macrolide Pneumonia Therapy in Children Not More Effective

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The results of this study question the routine empirical use of macrolide combination therapy in this population.

Zoonotic Potential of <i>C caviae</i> Resulting in Severe CAP Described

Zoonotic Potential of C caviae Resulting in Severe CAP Described

Three cases of community-acquired pneumonia involving Chlamydia caviae after exposure to ill guinea pigs have been described

Universal Pneumonia Vaccine in Development

Universal Pneumonia Vaccine in Development

Preclinical tests show the new vaccine stimulated an immune response to 72 of the more than 90 known strains of S pneumoniae.

Increase in Long-Term Risk of Pneumonia With GERD

Increase in Long-Term Risk of Pneumonia With GERD

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Gastroesophageal reflux disease is associated with long-term risk of pneumonia in a younger population of patients treated with PPIs.

FDA: Priority Review Granted to Expand Indications for Ceftazidime/Avibactam

FDA: Priority Review Granted to Expand Indications for Ceftazidime/Avibactam

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The FDA has granted priority review for Avycaz (ceftazidime/avibactam) to expand the current indications.

Effect of Omadacycline on Cardiac Parameters in ABSSSI and CABP

Effect of Omadacycline on Cardiac Parameters in ABSSSI and CABP

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Omadacycline was non-inferior to moxifloxacin for treatment of CABP and linezolid for treatment of ABSSSI.

Antibiotic Regimen Strategy for Improving Severe Community-Acquired Pneumonia

Antibiotic Regimen Strategy for Improving Severe Community-Acquired Pneumonia

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Patients who seem to benefit most from the combination of a macrolide with a β-lactam are patients with bacteremic pneumococcal pneumonia, septic shock, and invasive mechanical ventilation.

Efficacy of Procalcitonin-Guided Antimicrobial Stewardship Initiative for Diagnosing Pneumonia

Efficacy of Procalcitonin-Guided Antimicrobial Stewardship Initiative for Diagnosing Pneumonia

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Implementation of a procalcitonin diagnostic algorithm improves diagnostic yield and reduces hospital length of stay in bacterial pneumonia.

Minorities With Low Income and Poor Education Receive Lower Uptake of PCV13

Minorities With Low Income and Poor Education Receive Lower Uptake of PCV13

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Multiple disparities exist in rates of adult vaccination for 13-valent pneumococcal conjugate vaccine.

Efficacy of Delafloxacin in Treating Community-Acquired Bacterial Pneumonia

Efficacy of Delafloxacin in Treating Community-Acquired Bacterial Pneumonia

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The efficacy of delafloxacin in treating Streptococcus pneumoniae, Haemophilius influenzae, and Moraxella catarrhalis isolates was examined.

Macrolides Superior to Beta-Lactams in Pediatric Community-Acquired Pneumonia

Macrolides Superior to Beta-Lactams in Pediatric Community-Acquired Pneumonia

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Macrolides, despite inferior anti-pneumococcal activity, are the most commonly prescribed antibiotic class for CAP in Children.

Updated Guidelines for Management of Hospital-Acquired/Ventilator-Associated Pneumonia

Updated Guidelines for Management of Hospital-Acquired/Ventilator-Associated Pneumonia

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An international panel of experts applied the GRADE system and choose 7 PICO questions to generate recommendations for HAP/VAP.

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