Pneumonia

Combining Corticosteroids and Antibiotics May Be Cost-Effective in CAP

Combining Corticosteroids and Antibiotics May Be Cost-Effective in CAP

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Treating severe community-acquired pneumonia with a combination of corticosteroids and antibiotics may be a cost-effective strategy.

<i>Klebsiella pneumoniae</i> With PKS Gene Cluster Increases 30-Day Mortality

Klebsiella pneumoniae With PKS Gene Cluster Increases 30-Day Mortality

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Results showed pks carriage by a causative strain was an independent risk factor for 30-day mortality in patients with K pneumoniae bloodstream infections, especially when accompanied by MDR.

Invasive Pneumococcal Disease Risk Higher in Premature Infants

Invasive Pneumococcal Disease Risk Higher in Premature Infants

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Invasive pneumococcal disease was significantly higher in premature infants than in infants born at term.

Guideline Adoption for Childhood Community-Acquired Pneumonia

Guideline Adoption for Childhood Community-Acquired Pneumonia

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Recommendations in line with the current national guidelines for childhood CAP were found to be supported at pediatric primary care practices.

PCV13 Vaccine Protects Against Serotype 3 Invasive Pneumococcal Disease in Children

PCV13 Vaccine Protects Against Serotype 3 Invasive Pneumococcal Disease in Children

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A meta-analysis of case-control studies supports the use of the 13-valent pneumococcal conjugate vaccine in children as it protects against serotype 3.

IDSA/ATS CAP Guidelines Have Poor Specificity/Sensitivity for Some Bacteria

IDSA/ATS CAP Guidelines Have Poor Specificity/Sensitivity for Some Bacteria

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Recommended indications for Streptococcus pneumoniae and Legionella pneumophila antigen testing for CAP have poor sensitivity and specificity for identifying patients to screen.

Pneumococcal Vaccine Recommendations Cause Confusion Among Physicians

Pneumococcal Vaccine Recommendations Cause Confusion Among Physicians

While primary care physicians overwhelmingly recommend pneumococcal vaccines, there is a gap in their knowledge of how to implement related vaccine recommendations.

Epidemiology of <i>K pneumoniae</i> Carbapenemase-Producing Enterobacteriaceae Infections in Children

Epidemiology of K pneumoniae Carbapenemase-Producing Enterobacteriaceae Infections in Children

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Patients with Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae infections have multisystem disease and exposure to carbapenems and aminoglycosides.

Risk Factors for Multidrug-Resistant Pathogens in Pneumonia

Risk Factors for Multidrug-Resistant Pathogens in Pneumonia

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Previous antibiotic use and mechanical invasive ventilation were risk factors for multidrug-resistant pathogens in hospital-associated or ventilator-associated pneumonia.

Pneumococcal <i>H Influenzae</i> Protein D Conjugate Vaccine Effective in Children

Pneumococcal H Influenzae Protein D Conjugate Vaccine Effective in Children

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The burden of childhood and infant pneumonia can be effectively reduced through the use of the pneumococcal Haemophilus influenzae protein D conjugate vaccine.

Antipseudomonal Monotherapy Efficacious in Pneumonia

Antipseudomonal Monotherapy Efficacious in Pneumonia

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Antipseudomonal combination therapy has shown poorer efficacy than antipseudomonal monotherapy in individuals with suspected pseudomonal pneumonia.

PCV13 in Young Adults With Diabetes Could Avert Pneumonia Hospitalizations

PCV13 in Young Adults With Diabetes Could Avert Pneumonia Hospitalizations

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PCV13 in adults age <65 years with diabetes could reduce a substantial number of pneumonia hospitalizations.

Omadacycline Approved for  Community-Acquired Bacterial Pneumonia, Skin Infections

Omadacycline Approved for Community-Acquired Bacterial Pneumonia, Skin Infections

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The approval was based on Phase 3 data from 2 studies in ABSSSI, where treatment with Nuzyra was compared with linezolid, and 1 study in CABP comparing Nuzyra with moxifloxacin. Across all 3 trials, Nuzyra was found to be effective and generally safe and well-tolerated.

Antibiotic Stewardship May Aid Stepdown Therapies for Community-Acquired Pneumonia

Antibiotic Stewardship May Aid Stepdown Therapies for Community-Acquired Pneumonia

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The use of fluoroquinolones in stable patients with community-acquired pneumonia can be reduced with stewardship programs that share antibiotic use data and provide guidance for step-down therapy.

Improving Rates of Combination Pneumococcal Vaccination in Patients With SLE

Improving Rates of Combination Pneumococcal Vaccination in Patients With SLE

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Pneumococcal vaccination rates in patients with systemic lupus erythematosus improved significantly after the implementation of a multifaceted intervention at a rheumatology practice.

Chest Radiograph Effective for Excluding Pediatric Pneumonia

Chest Radiograph Effective for Excluding Pediatric Pneumonia

A negative chest radiograph accurately excludes pneumonia in the majority of children.

Positive Results for Ceftolozane/Tazobactamin Phase 3 Study of Ventilated HABP, VABP Patients

Positive Results for Ceftolozane/Tazobactamin Phase 3 Study of Ventilated HABP, VABP Patients

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The full findings from the study will be presented at a future scientific conference; Merck plans to include the data in a supplemental New Drug Application for Zerbaxa which will be submitted to the Food and Drug Administration.

Influenza an Independent Risk Factor for Invasive Pulmonary Aspergillosis

Influenza an Independent Risk Factor for Invasive Pulmonary Aspergillosis

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Influenza proved to be an independent risk factor for invasive pulmonary aspergillosis.

Therapeutic Algorithm May Guide Empiric Therapy in Pneumonia

Therapeutic Algorithm May Guide Empiric Therapy in Pneumonia

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An algorithm based on risk factors for resistant pathogens and illness severity can simplify pneumonia treatment, improve the accuracy of empiric therapy, reduce mortality, and help avoid overusing broad spectrum therapy in some patients.

Long-Term PPI Use Linked to Pneumonia Risk in Older Adults

Long-Term PPI Use Linked to Pneumonia Risk in Older Adults

Rate of incident pneumonia increased in second year after initiating treatment with proton pump inhibitors

Gram-Negative Bacteria Antibiotic Susceptibility for Pneumonia in the ICU

Gram-Negative Bacteria Antibiotic Susceptibility for Pneumonia in the ICU

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Antimicrobial agents ceftazidime/avibactam and amikacin provided the best overall coverage against Gram-negative organisms isolated from patients with pneumonia in the ICU.

FDA Approves Omadacycline for Skin Infections, Pneumonia

FDA Approves Omadacycline for Skin Infections, Pneumonia

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The Committee's recommendation was based on data from the omadacycline global development program that included nearly 2000 adults in three Phase 3 studies.

Immunogenicity of Co-Administered Herpes Zoster, Pneumonia Vaccine Assessed

Immunogenicity of Co-Administered Herpes Zoster, Pneumonia Vaccine Assessed

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A new study found no immunologic interference with the co-administration of Shingrix vaccine and the PCV 23 in adult patients

Community-Acquired Pneumonia In-Hospital Deaths Are Not Indicative of Lapse in Care

Community-Acquired Pneumonia In-Hospital Deaths Are Not Indicative of Lapse in Care

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Most deaths related to community-acquired pneumonia that occurred at tertiary-case hospitals were not preventable.

PCV13 Reduces Hospitalization for Vaccine-Type Community-Acquired Pneumonia

PCV13 Reduces Hospitalization for Vaccine-Type Community-Acquired Pneumonia

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The real-world effectiveness of PCV13 vaccine in preventing hospitalization for vaccine-type community-acquired pneumonia was assessed.

C-Reactive Protein as a Biomarker for CAP in Bronchiectasis

C-Reactive Protein as a Biomarker for CAP in Bronchiectasis

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Although clinical presentation was similar in both community-acquired pneumonia and non-pneumonia exacerbations, CRP, glucose, and leukocytes were higher in the former vs the latter.

Early Clinical Response With Omadacycline vs Moxifloxacin in CABP

Early Clinical Response With Omadacycline vs Moxifloxacin in CABP

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Early clinical response rates were similar across PORT risk class subgroups in patients with community-acquired bacterial pneumonia when treated with omadacycline or moxifloxacin.

Prevnar 13 Linked to Reduced Risk of CAP Hospitalization in Older Patients

Prevnar 13 Linked to Reduced Risk of CAP Hospitalization in Older Patients

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PCV13, marketed as Prevnar 13, was evaluated in a test-negative case-control study in real-world conditions where patients were administered pneumococcal vaccination as advised by their healthcare providers.

Prior Atypical Antipsychotic Use May Increase Mortality Risk in Pneumonia

Prior Atypical Antipsychotic Use May Increase Mortality Risk in Pneumonia

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Clinicians should consider these findings when using atypical antipsychotics in patients at risk for pneumonia.

Pediatric Pneumonia: Sensitivity of Lung Ultrasound vs Chest Radiography

Pediatric Pneumonia: Sensitivity of Lung Ultrasound vs Chest Radiography

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Lung ultrasound was more effective in diagnosing pediatric community-acquired pneumonia than chest radiography.

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