Pneumonia

FDA Approves Omadacycline for Skin Infections, Pneumonia

FDA Approves Omadacycline for Skin Infections, Pneumonia

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The Committee's recommendation was based on data from the omadacycline global development program that included nearly 2000 adults in three Phase 3 studies.

Immunogenicity of Co-Administered Herpes Zoster, Pneumonia Vaccine Assessed

Immunogenicity of Co-Administered Herpes Zoster, Pneumonia Vaccine Assessed

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A new study found no immunologic interference with the co-administration of Shingrix vaccine and the PCV 23 in adult patients

Community-Acquired Pneumonia In-Hospital Deaths Are Not Indicative of Lapse in Care

Community-Acquired Pneumonia In-Hospital Deaths Are Not Indicative of Lapse in Care

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Most deaths related to community-acquired pneumonia that occurred at tertiary-case hospitals were not preventable.

PCV13 Reduces Hospitalization for Vaccine-Type Community-Acquired Pneumonia

PCV13 Reduces Hospitalization for Vaccine-Type Community-Acquired Pneumonia

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The real-world effectiveness of PCV13 vaccine in preventing hospitalization for vaccine-type community-acquired pneumonia was assessed.

C-Reactive Protein as a Biomarker for CAP in Bronchiectasis

C-Reactive Protein as a Biomarker for CAP in Bronchiectasis

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Although clinical presentation was similar in both community-acquired pneumonia and non-pneumonia exacerbations, CRP, glucose, and leukocytes were higher in the former vs the latter.

Early Clinical Response With Omadacycline vs Moxifloxacin in CABP

Early Clinical Response With Omadacycline vs Moxifloxacin in CABP

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Early clinical response rates were similar across PORT risk class subgroups in patients with community-acquired bacterial pneumonia when treated with omadacycline or moxifloxacin.

Prevnar 13 Linked to Reduced Risk of CAP Hospitalization in Older Patients

Prevnar 13 Linked to Reduced Risk of CAP Hospitalization in Older Patients

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PCV13, marketed as Prevnar 13, was evaluated in a test-negative case-control study in real-world conditions where patients were administered pneumococcal vaccination as advised by their healthcare providers.

Prior Atypical Antipsychotic Use May Increase Mortality Risk in Pneumonia

Prior Atypical Antipsychotic Use May Increase Mortality Risk in Pneumonia

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Clinicians should consider these findings when using atypical antipsychotics in patients at risk for pneumonia.

Pediatric Pneumonia: Sensitivity of Lung Ultrasound vs Chest Radiography

Pediatric Pneumonia: Sensitivity of Lung Ultrasound vs Chest Radiography

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Lung ultrasound was more effective in diagnosing pediatric community-acquired pneumonia than chest radiography.

Positive Results Announced for Pleuromutilin Antibiotic in CABP

Positive Results Announced for Pleuromutilin Antibiotic in CABP

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In the LEAP 2 study (N=738), patients with moderate CABP received either oral lefamulin 600mg every 12 hours for 5 days or oral moxifloxacin 400mg once daily for 7 days.

MenACWY-TT Vaccine Can Be Effectively Coadministered With Routine Pediatric Immunizations

MenACWY-TT Vaccine Can Be Effectively Coadministered With Routine Pediatric Immunizations

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Study showed that DTPa-HBV-IPV/Hib and PHiD-CV coadministered with MenACWY-TT in infants and toddlers were immunogenic with an acceptable reactogenicity profile.

Low-Dose CT May Modify Pneumonia Diagnosis in Elderly Patients

Low-Dose CT May Modify Pneumonia Diagnosis in Elderly Patients

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Low-dose computed tomography may assist clinicians in modifying diagnosis of elderly patients who are admitted with suspected pneumonia.

<i>Legionella</i> Pneumonia Outcomes Similar in Adults With/Without HIV

Legionella Pneumonia Outcomes Similar in Adults With/Without HIV

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Clinical presentation and outcomes in HIV-infected patients with Legionella pneumonia did not differ from patients without HIV infection.

Effect of Pneumococcal Vaccination With PCV10 on All-Cause Acute Otitis Media

Effect of Pneumococcal Vaccination With PCV10 on All-Cause Acute Otitis Media

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In this whole-population study, researchers demonstrated a 22% vaccine effect of the 10-valent pneumococcal conjugate vaccine on all-cause acute otitis media.

Military Personnel Remain at Risk for Infection Long After Hospital Discharge

Military Personnel Remain at Risk for Infection Long After Hospital Discharge

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Deployment-related trauma infectious complications continue after initial hospital discharge and into Veterans Affairs healthcare.

Infections Complicating the Use of Monoclonal Antibodies for Malignancy

Infections Complicating the Use of Monoclonal Antibodies for Malignancy

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In this review, David C. Helfgott, MD, editorial advisory board member for Infectious Disease Advisor, focuses on infectious complications from the use of monoclonal antibodies for malignancy.

Pneumonia Risk in Severe COPD Linked to Elevated Eosinophil Count

Pneumonia Risk in Severe COPD Linked to Elevated Eosinophil Count

A higher proportion of patients with COPD and a blood eosinophil count of ≥0.34×109/L had elevated markers of low-grade systemic inflammation regardless of forced expiratory volume in 1 second.

Mortality in Mechanically Ventilated Community-Acquired Pneumonia With or Without ARDS

Mortality in Mechanically Ventilated Community-Acquired Pneumonia With or Without ARDS

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The risk for death in patients with community-acquired pneumonia who were given mechanical ventilation does not seem to be affected by the presence of acute respiratory distress syndrome.

Pneumonia and Influenza May Trigger Acute MI, Stroke

Pneumonia and Influenza May Trigger Acute MI, Stroke

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Researchers found increased myocardial infarction rates during the week after Streptococcus pneumoniae and influenza infections.

Inflammatory Markers in CAP Influenced by Time From Symptom Onset to Presentation

Inflammatory Markers in CAP Influenced by Time From Symptom Onset to Presentation

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Differences in serum inflammatory markers may exist between patients with community-acquired pneumonia who present within the first 48 hours of symptom onset vs those who present later.

Comparing Diagnostic Imaging for Community-Acquired Pneumonia

Comparing Diagnostic Imaging for Community-Acquired Pneumonia

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Adults with community-acquired pneumonia that is visualized on CT scan but not on concurrent chest radiograph have similar pathogens, disease severity, and outcomes as patients who had pneumonia confirmed via chest radiograph.

Omadacycline Granted Priority Review for CABP, Skin/Skin Structure Infections

Omadacycline Granted Priority Review for CABP, Skin/Skin Structure Infections

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Omadacycline met all required FDA and European Medicines Agency primary endpoints in each study and demonstrated a generally safe and well-tolerated profile.

Predictive Model Identifies Risk Factors for Bacteremia in Pneumococcal Pneumonia

Predictive Model Identifies Risk Factors for Bacteremia in Pneumococcal Pneumonia

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Researchers retrospectively analyzed data from patients hospitalized with pneumococcal community-acquired pneumonia to determine risk factors for pneumococcal bacteremia.

Azithromycin Timing Not Associated With Childhood Mycoplasma Pneumonia Outcomes

Azithromycin Timing Not Associated With Childhood Mycoplasma Pneumonia Outcomes

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Researchers assessed the timing of azithromycin administration for pediatric community-acquired pneumonia to determine its effectiveness in the setting of macrolide resistance.

Pneumonia: Inflammation Linked to Cardiovascular Complications

Pneumonia: Inflammation Linked to Cardiovascular Complications

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Community-acquired pneumonia and other acute infections can cause or exacerbate cardiovascular complications.

No Benefit From Prophylactic Antimicrobials in Aspiration Pneumonitis

No Benefit From Prophylactic Antimicrobials in Aspiration Pneumonitis

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Use of prophylactic antimicrobial therapy was not associated with a reduction in mortality or transfer to critical care compared with patients managed with supportive care only.

Prognostic Role of Serum Angiopoietin in Pneumonia-Induced Acute Lung Failure

Prognostic Role of Serum Angiopoietin in Pneumonia-Induced Acute Lung Failure

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Researchers investigated the prognostic and pathogenetic effect of angiopoietins in regulating pulmonary vascular barrier function and inflammation in bacterial pneumonia.

Preventing Hospitalizations in the Elderly: High-Dose vs Standard-Dose Influenza Vaccine

Preventing Hospitalizations in the Elderly: High-Dose vs Standard-Dose Influenza Vaccine

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In protecting senior Veterans Health Administration patients against influenza- or pneumonia-associated hospitalization, high-dose influenza vaccine was more effective than standard-dose vaccine.

Pulse Oximetry May Aid Pneumonia Diagnosis in Patients With Lower Respiratory Tract Infections

Pulse Oximetry May Aid Pneumonia Diagnosis in Patients With Lower Respiratory Tract Infections

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The utilization of this tool could prevent severe complications secondary to delayed pneumonia diagnosis and treatment.

Antibiotic Stewardship: Role of MRSA Nasal Screening

Antibiotic Stewardship: Role of MRSA Nasal Screening

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MRSA nares screening can be a stewardship tool to streamline empiric antibiotic therapy among those not nares colonized with MRSA.

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