Pregnancy

Labeling for Two HIV Drugs Updated With Safety, PK Data for Pregnant Patients

Labeling for Two HIV Drugs Updated With Safety, PK Data for Pregnant Patients

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The "8.1 Pregnancy" and "12.3 Pharmacokinetics" sections have been updated with data showing no increase in the risk of overall major birth defects with 1st trimester exposure for rilpivirine.

Optimal Pertussis Toxin Antibodies Achieved With Third Trimester Tdap Vaccination

Optimal Pertussis Toxin Antibodies Achieved With Third Trimester Tdap Vaccination

Immunization with Tdap vaccine during the third trimester of pregnancy resulted in higher concentrations of pertussis toxin antibodies in newborns.

Contraceptive Use Inadequate Among Young Women With HIV

Contraceptive Use Inadequate Among Young Women With HIV

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Effective contraception, condoms, and dual method use was inadequately low in a cohort of young HIV-positive women.

Sustained Follow-Up Essential for Infants of Women Exposed to Zika Virus

Sustained Follow-Up Essential for Infants of Women Exposed to Zika Virus

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Approximately 14% of children who were born to mothers with confirmed or possible Zika virus infection during pregnancy were identified during infancy or early childhood as having a Zika-associated birth defect.

CDC Updates Guidance for Post-Zika Virus Exposure Counseling in Males

CDC Updates Guidance for Post-Zika Virus Exposure Counseling in Males

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In an updated interim guidance, the CDC now recommends that couples wait at least 3 months before attempting to conceive after possible Zika virus exposure in the male.

Safety and Immunogenicity of Tdap Vaccine Immunization During Pregnancy

Safety and Immunogenicity of Tdap Vaccine Immunization During Pregnancy

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Immunization with Tdap vaccine during pregnancy results in higher levels of antibodies early in infancy but lower levels after the primary vaccine series.

Comparison of Live Attenuated vs Inactive Influenza Vaccine in Nursing Mothers

Comparison of Live Attenuated vs Inactive Influenza Vaccine in Nursing Mothers

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Both LAIV and IIV are safe for nursing mothers, however, breast milk and serum antibody responses were higher for IIV.

Amniotic Fluid Is Sterile in Uncomplicated Term Pregnancies

Amniotic Fluid Is Sterile in Uncomplicated Term Pregnancies

Fetal development in uncomplicated pregnancies occurs in the absence of amniotic fluid microbiota and offspring microbial colonization starts after uterine contractions and rupture of amniotic membrane.

HSV-1 and HSV-2 Seroprevalence Among Pregnant Women in the United States

HSV-1 and HSV-2 Seroprevalence Among Pregnant Women in the United States

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Further investigation into new strategies to prevent herpes simplex virus (HSV) acquisition in pregnant women and to prevent HSV transmission from mother to neonate are warranted.

Risk of Adverse Birth Outcomes in Women With HIV Using Tenofovir-Emtricitabine

Risk of Adverse Birth Outcomes in Women With HIV Using Tenofovir-Emtricitabine

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The number of adverse birth outcomes was not higher with tenofovir, emtricitabine, and ritonavir-boosted lopinavir than with zidovudine, lamivudine, and ritonavir-boosted lopinavir or tenofovir, emtricitabine, and ritonavir-boosted atazanavir in HIV-infected women and their infants in the United States.

In-utero exposure to tenofovir-emtricitabine not associated with higher risk of adverse birth outcomes

Pairwise comparisons of tenofovir-emtricitabine and ritonavir-boosted lopinavir (TDF-FTC-LPV/r), zidovudine-lamivudine and ritonavir-boosted lopinavir (ZDV-3TC-LPV/r), and tenofovir-emtricitabine and ritonavir-boosted atazanavir (TDF-FTC-ATV/r) HIV regimens among pregnant women with HIV showed all 3 regimens had comparable risks of preterm birth, low birth weight, and neonatal death.

ACOG: Updated Recommendations for Influenza Vaccination During Pregnancy

ACOG: Updated Recommendations for Influenza Vaccination During Pregnancy

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This updated Committee Opinion includes more recent data on the safety and efficacy of influenza vaccination during pregnancy, as well as recommendations for treatment and postexposure chemoprophylaxis.

About Half of Pregnant Women With HIV Have C-Sections

About Half of Pregnant Women With HIV Have C-Sections

About half of pregnant women with HIV infection underwent cesarean delivery between 1998 and 2013.

Risk Factors for Cytomegalovirus Reinfections in Seropositive Women

Risk Factors for Cytomegalovirus Reinfections in Seropositive Women

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Findings provide an alternative explanation for virus acquisition and shedding in seroimumne pregnant women that contrasts with proposed mechanisms that argue that reactivation of persistent infection in seroimmune women leads to infection and virus shedding.

CDC Recommends Additional Malaria Treatment Option During Pregnancy

CDC Recommends Additional Malaria Treatment Option During Pregnancy

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Women in the United States with uncomplicated malaria during the first trimester of pregnancy should be treated with the currently recommended options of either mefloquine or quinine plus clindamycin. However, when neither of these options is available, artemether-lumefantrine should be considered for treatment.

HIV-1 Susceptibility Increases in Late Pregnancy and Postpartum Periods

HIV-1 Susceptibility Increases in Late Pregnancy and Postpartum Periods

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Researchers assessed the differential risk of acquiring HIV-1 infection across reproductive stages by calculating per-coital-act risk for each stage and comparing with nonpregnant times.

Rate of Birth Defects in Pregnant Women With Confirmed Zika Virus Infection

Rate of Birth Defects in Pregnant Women With Confirmed Zika Virus Infection

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Researchers estimated this risk among pregnant women with symptomatic Zika virus infection in French territories in the Americas.

No difference between tenofovir and placebo in reducing perinatal transmission of hepatitis B

Hepatitis B e-antigen positive mothers receiving tenofovir daily from 28-weeks gestation to 2 months postpartum did not show significant reductions in HBV transmission rates compared to placebo treated participants.

Risk of Infant Hospitalizations, Death Not Linked to Maternal Vaccination

Risk of Infant Hospitalizations, Death Not Linked to Maternal Vaccination

Maternal receipt of influenza and tetanus toxoid, reduced diphtheria toxoid, and Tdap vaccines is not associated with infant hospitalization or death.

Maternal vaccination during pregnancy not associated with infant hospitalization, mortality

No significant association was identified between maternal intrapartum vaccination with the influenza or tetanus, diphtheria, and acellular pertussis (Tdap) vaccine and infant hospitalization or mortality.

Chlamydia Infection Not Associated With Adverse Birth Outcomes

Chlamydia Infection Not Associated With Adverse Birth Outcomes

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A chlamydia infection that has been identified during pregnancy and treated does not appear to result in a substantial increase in the risk of preterm birth compared with the risk in women tested and shown to not have a chlamydia infection.

Antibiotic Prescribing Habits for UTI in Pregnant Women

Antibiotic Prescribing Habits for UTI in Pregnant Women

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For pregnant women in their first trimester, a 2011 Committee Opinion from the ACOG recommended that sulfonamides and nitrofurantoin may be prescribed only if other antimicrobial therapies are deemed clinically inappropriate.

Tenofovir Use Safe During Pregnancy

Tenofovir Use Safe During Pregnancy

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Further research on longer-term effects of maternal prenatal TDF use is important given the majority of HIV-infected women are prescribed a TDF-containing prevention of mother-to-child transmission regimen.

New Recommendations for Managing Hepatitis C Infection During Pregnancy

New Recommendations for Managing Hepatitis C Infection During Pregnancy

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The recommendations will be published in the November issue of the American Journal of Obstetrics and Gynecology.

New ART Recommendations for Pregnant Women With HIV

New ART Recommendations for Pregnant Women With HIV

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The GRADE framework recommendations provide guidance for combination treatment regimens based on 2 systemic reviews, patient considerations, fetal outcomes, and practical issues.

Link Between Influenza Vaccine, Spontaneous Abortion Further Clarified

Link Between Influenza Vaccine, Spontaneous Abortion Further Clarified

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Pregnant women who received vaccines containing the pH1N1 antigen for 2 consecutive influenza seasons may have increased risk for spontaneous abortion 28 days postvaccination.

HPV Vaccine Does Not Increase Risk for Adverse Maternal, Infant Outcomes

HPV Vaccine Does Not Increase Risk for Adverse Maternal, Infant Outcomes

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Inadvertent administration of the quadrivalent HPV vaccine during periconception or pregnancy was not associated with additional risk to mothers and their infants.

Viral Load Rebound Seen After HIV Suppression in Pregnancy

Viral Load Rebound Seen After HIV Suppression in Pregnancy

Women achieving HIV viral suppression in pregnancy can experience viral load rebound predelivery.

Risk of Congenital Malformations With Gestational Antibiotic Use

Risk of Congenital Malformations With Gestational Antibiotic Use

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The use of specific antibiotics during pregnancy may be associated with increased risk for major congenital malformations.

Prior Maternal Flu Vaccination Does Not Affect Newborn Antibody Titers

Prior Maternal Flu Vaccination Does Not Affect Newborn Antibody Titers

Prior influenza vaccination predicts higher baseline antibody titers and decreased peak antibody responses against all influenza strains in pregnant women.

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