Risk of Infant Hospitalizations, Death Not Linked to Maternal Vaccination

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No correlation was identified between infant mortality and maternal influenza or Tdap vaccinations.
No correlation was identified between infant mortality and maternal influenza or Tdap vaccinations.

HealthDay News — Maternal receipt of influenza and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines is not associated with infant hospitalization or death in the first 6 months of life, according to a study published in Pediatrics.

Lakshmi Sukumaran, MD, MPH, from the US Centers for Disease Control and Prevention in Atlanta, and colleagues examined the correlation between maternal receipt of influenza and Tdap vaccines and the risk of infant hospitalization or death. Singleton, live-birth pregnancies in the Vaccine Safety Datalink between 2004 and 2014 were included.

The researchers identified 413,034 live births in the population. In the first 6 months of life, 25,222 infants had hospitalizations and 157 infants died. 

There was no correlation between infant hospitalization and maternal influenza (adjusted odds ratio, 1; 95% CI, 0.96 to 1.04) or Tdap (adjusted odds ratio, 0.94; 95% CI, 0.88 to 1.01) vaccinations. No correlation was identified between infant mortality and maternal influenza (adjusted odds ratio, 0.96; 95% CI, 0.54 to 1.69) or Tdap (adjusted odds ratio, 0.44; 95% CI, 0.17 to 1.13) vaccinations.

"These findings support the safety of current recommendations for influenza and Tdap vaccination during pregnancy," the authors wrote.

Two authors disclosed financial ties to the pharmaceutical industry.

Reference

Sukumaran L, McCarthy NL, Kharbanda EO, et al. Infant hospitalizations and mortality after maternal vaccination [published online February 20, 2018]. Pediatrics. doi: 10.1542/peds.2017-3310

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