Prevention

Factors Increasing Risk for Hemorrhagic Stroke After Infective Endocarditis

Factors Increasing Risk for Hemorrhagic Stroke After Infective Endocarditis

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The apparent increase in risk for hemorrhagic stroke among patients with previous infective endocarditis was explained by the mediating factors of mechanical heart valve insertion, atrial fibrillation, and anticoagulation medication.

Harms Reporting Limited in Trials of Prebiotics, Probiotics, Synbiotics

Harms Reporting Limited in Trials of Prebiotics, Probiotics, Synbiotics

A considerable number of randomized controlled trials of probiotics, prebiotics, or synbiotics do not report harms-related data and/or safety results.

Inadvertent Quadrivalent HPV Vaccine Exposure Not Associated With Spontaneous Abortion Risk

Inadvertent Quadrivalent HPV Vaccine Exposure Not Associated With Spontaneous Abortion Risk

The quadrivalent HPV vaccine is not associated with an increased risk of spontaneous abortion when inadvertently given before or during pregnancy.

TPOXX Approved for the Treatment of Human Smallpox Disease

TPOXX Approved for the Treatment of Human Smallpox Disease

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The approval was supported by findings from 12 clinical trials of TPOXX with more than 700 healthy volunteers that showed no drug-related serious adverse events.

Promising Early Results With P27A Candidate Vaccine for Malaria Prevention

Promising Early Results With P27A Candidate Vaccine for Malaria Prevention

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Early findings show that the P27A candidate vaccine for malaria prevention appeared to be safe and induced a strong immunogenic response with parasite growth inhibitory capacity.

Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy

Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy

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A tetravalent dengue vaccine protective against severe virologically confirmed dengue and hospitalization because of VCD for 5 years in patients with previous dengue exposure before vaccination.

Mosaic HIV-1 Vaccine Induces Responses in Humans and Monkeys

Mosaic HIV-1 Vaccine Induces Responses in Humans and Monkeys

Mosaic adenovirus serotype 26-based vaccine induces immune responses in humans, rhesus monkeys

FDA Announces New Drug Shortages Task Force

FDA Announces New Drug Shortages Task Force

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Gottlieb said "The charge to this new task force is to look for holistic solutions to addressing the underlying causes for these [drug] shortages."

Routine ED Pelvic Exam May Not Improve STI Diagnosis in Young Women

Routine ED Pelvic Exam May Not Improve STI Diagnosis in Young Women

Pelvic examination does not increase the sensitivity or specificity for diagnosis of chlamydia, gonorrhea, or trichomonas over taking a history alone for young female patients presenting to the emergency department.

Quick Sequential Organ Failure Assessment Score Effectively Identifies Patients With High Mortality Risk

Quick Sequential Organ Failure Assessment Score Effectively Identifies Patients With High Mortality Risk

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qSOFA score can identify patients with suspected infection, who are at a higher risk for excess hospital mortality.

Public Health Vaccine Opposition Growing in the United States

Public Health Vaccine Opposition Growing in the United States

Inverse association identified between NME rate and MMR vaccine coverage of kindergarteners

Blister Packs for Several Meds Recalled Due to Risk of Harm to Children

Blister Packs for Several Meds Recalled Due to Risk of Harm to Children

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The recall affects approximately 470,000 units that include drugs packaged with 3 to 10 tablets per blister card. The blister packs were developed for use in hospitals, however some were sent to retail pharmacies and were likely dispensed for in-home use.

Universal Purchase Programs in the United States May Not Effectively Increase Vaccination Rates

Universal Purchase Programs in the United States May Not Effectively Increase Vaccination Rates

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Using state- and individual-level data from the 1995-2014 National Immunization Survey, the effect of a state's Universal Purchase adoption on vaccination rates was estimated.

Are Hospital Staff Failing to Practice Transmission-Based Precautions?

Are Hospital Staff Failing to Practice Transmission-Based Precautions?

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Active failures in personal protective equipment use by healthcare personnel may potentially lead to self-contamination.

Latent Toxoplasma Infection Occurs More Frequently in Schizophrenia

Latent Toxoplasma Infection Occurs More Frequently in Schizophrenia

Investigators examined whether latent toxoplasma infection was associated with higher levels of psychotic symptomatology.

BCG Vaccine Tied to Reduced Hyperglycemia in Type 1 Diabetes

BCG Vaccine Tied to Reduced Hyperglycemia in Type 1 Diabetes

The Bacillus Calmette Guérin vaccine is associated with a reduction in hyperglycemia among patients with type 1 diabetes with long-term disease.

From Needle Exchanges to Supervised Injection

From Needle Exchanges to Supervised Injection

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Like needle exchanges before them, supervised injection sites have been shown to decrease the harms associated with injection drug use.

Unplanned Pregnancies Prevalent Among HIV-Positive Women

Unplanned Pregnancies Prevalent Among HIV-Positive Women

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Researchers examined unplanned pregnancies and contraceptive use among HIV-positive women in a cross-sectional study.

Pharmacists Are Well Placed to Improve Adult Vaccination Rates

Pharmacists Are Well Placed to Improve Adult Vaccination Rates

Pharmacists can help increase adult vaccination rates by offering vaccination at lower cost and greater convenience.

HPV Vaccine Under Priority Review for Expanded Age Range

HPV Vaccine Under Priority Review for Expanded Age Range

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Specifically, the types the vaccine protects against are HPV 16, 18, 31, 33, 45, 52, 58 (which cause ~90% of cervical cancer cases worldwide), and types 6 and 11 which case genital warts.

Provider Engagement With Hesitant Parents May Increase HPV Vaccination Rates

Provider Engagement With Hesitant Parents May Increase HPV Vaccination Rates

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Investigators examined parental hesitancy when discussing human papillomavirus vaccination with providers.

Active Failures Seen in Proper Use of Personal Protective Equipment

Active Failures Seen in Proper Use of Personal Protective Equipment

Active failures frequently occur in infectious agent transmission-based precautions, including personal protective equipment use.

Many AKI Reports in FAERS Linked to Drugs Not Recognized as Nephrotoxic

Many AKI Reports in FAERS Linked to Drugs Not Recognized as Nephrotoxic

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According to the authors, this is the first study to identify medications most commonly reported for a specific adverse reaction using this database.

Kitchen Towels Are Source of Possibly Pathogenic Bacteria

Kitchen Towels Are Source of Possibly Pathogenic Bacteria

Family composition and hygiene practices are associated with the microbial load of kitchen towels.

CDC: Get Vaccinated for Measles Before Traveling

CDC: Get Vaccinated for Measles Before Traveling

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The CDC recommends 2 doses of the MMR vaccine, which provides 97% protection against measles, prior to international travel.

Varicella Zoster Vaccine Effective for Hematopoietic Stem Cell Transplant Recipients

Varicella Zoster Vaccine Effective for Hematopoietic Stem Cell Transplant Recipients

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In a phase 3 clinical trial, early vaccination effectively prevented herpes zoster in auto-HSCT recipients.

Pegfilgrastim Biosimilar FDA Approved to Decrease Infection Risk in Febrile Neutropenia

Pegfilgrastim Biosimilar FDA Approved to Decrease Infection Risk in Febrile Neutropenia

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Fulphila will be available as a 6mg/0.6mL single-dose prefilled syringe for subcutaneous (SC) injection.

Micafungin Prophylaxis Effective for Chemotherapy-Induced Neutropenia in ALL, MDS

Micafungin Prophylaxis Effective for Chemotherapy-Induced Neutropenia in ALL, MDS

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A study sought to compare the effectiveness of micafungin vs posaconazole prophylaxis during chemotherapy-induced neutropenia for ALL and MDS.

Is Current Hib Vaccine Effectiveness Decreasing in Children?

Is Current Hib Vaccine Effectiveness Decreasing in Children?

The hexavalent DTPa-HBV-IPV/Hib vaccine may not affect Hib vaccine efficacy.

CDC: Administration Errors Reported With New Shingles Vaccine

CDC: Administration Errors Reported With New Shingles Vaccine

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Between October 20, 2017 and February 20, 2018, the Vaccine Adverse Event Reporting System (VAERS) received 155 reports involving RZV, with 13 (8%) involving an administrative error.

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