Effect of Vaccine Antigen Exposure in First 23 Months of Life

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None of the secondary analyses revealed a statistically significant association between estimated cumulative or maximum single-day antigen exposure and non–vaccine-targeted infections.
None of the secondary analyses revealed a statistically significant association between estimated cumulative or maximum single-day antigen exposure and non–vaccine-targeted infections.

HealthDay News — The estimated cumulative vaccine antigen exposure through age 23 months does not differ significantly for children with vs those without hospital visits for infectious diseases not targeted by vaccines from age 24 to 47 months, according to a study published in the Journal of the American Medical Association.

Jason M. Glanz, PhD, from Kaiser Permanente Colorado in Denver, and colleagues conducted a nested case-control study in children aged 24 through 47 months in 6 US health care organizations.

Cases were identified by International Classification of Diseases codes for infectious diseases in the emergency department and inpatient medical settings; cases of non-vaccine-targeted infection were matched by age, sex, health care organization site, and chronic disease status to controls (193 cases and 751 controls).

The researchers found that the estimated mean cumulative vaccine antigen exposure was 240.6 for cases and 242.9 for controls through the first 23 months. For estimated cumulative antigen exposure, the between-group difference was −2.3 (95% CI, −10.1 to 5.4; P =.55).

The matched odds ratio for estimated cumulative antigen exposure through 23 months was not significant among children with vs those without non-vaccine-targeted infections from 24 through 47 months of age (matched odds ratio, 0.94; 95% CI, 0.84 to 1.07).

"This study did not reveal any beneficial or detrimental associations with estimated cumulative vaccine antigen exposure in young children with non-vaccine-targeted infections," the authors write.

One author disclosed financial ties to the pharmaceutical industry.

Reference

Glanz JM, Newcomer SR, Daley MF, et al. Association between estimated cumulative vaccine antigen exposure through the first 23 months of life and non-vaccine-targeted infections from 24 through 47 months of age. JAMA. 2018; 319(9): 906-913.

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