Respiratory Feature Archive

A Pan-Tuberculosis Regimen: The Debate Continues

A Pan-Tuberculosis Regimen: The Debate Continues

Last month the South Africa National Tuberculosis Program decided to make oral bedaqualine available for all rifampin-resistant TB (RR-TB) in place of — the often more toxic — injectable drugs.

Could a New Universal Tuberculosis Regimen Help End the TB Pandemic?

Could a New Universal Tuberculosis Regimen Help End the TB Pandemic?

The Lancet Respiratory Medicine staged a debate between proponents and opponents of pan-TB regimens to tackle the current suboptimal worldwide management of TB resistance.

A 56-Year-Old Man With Flu-Like Symptoms Presents With Palpitations

A 56-Year-Old Man With Flu-Like Symptoms Presents With Palpitations

A 56-year-old man with improved flu-like symptoms, but marked shortness of breath and palpitations, presents to an urgent care center.

Case: Fever, Generalized Weakness One Year After Heart Transplant

Case: Fever, Generalized Weakness One Year After Heart Transplant

Middle-aged woman who received a heart transplant 1 year ago because of dilated cardiomyopathy now presents with mild fever and generalized weakness.

Case Study: Persistent Upper Respiratory Infection in a 44-Year-Old Man

Case Study: Persistent Upper Respiratory Infection in a 44-Year-Old Man

A middle-aged man with no significant medical history presents to the local urgent care center after 3 days of fevers, sore throat, rhinitis, coughing, and myalgia.

Update on Latent Tuberculosis Testing and Treatment

Update on Latent Tuberculosis Testing and Treatment

A representative from the California Department of Public Health discusses latent TB infection testing and treatment recommendations and reasons why US physicians have been slow to test for and treat for the condition.

Challenges in Diagnosing Tuberculous Meningitis

Challenges in Diagnosing Tuberculous Meningitis

Diagnosis of tuberculous meningitis is challenging, although new, next-generation rapid POC testing holds promise for greatly improved sensitivity. Shorter and more effective treatments are needed.

M tuberculosis Disrupts Regulatory Macrophage Pathways Driving Immunopathology

M tuberculosis Disrupts Regulatory Macrophage Pathways Driving Immunopathology

Mycobacterium tuberculosis engages the host immune response to drive immunopathology and tissue destruction by disrupting negative regulatory pathways in human macrophages.

A Commentary on the FDA's Advice to Avoid Fluoroquinolones for Mild Infections

A Commentary on the FDA's Advice to Avoid Fluoroquinolones for Mild Infections

The FDA now advises against choosing fluoroquinolones to treat certain common infections when alternate antibiotics are available.

Addressing Altered Vaccine Immunogenicity and Low Vaccination Rates in Those With Autoimmune Diseases

Addressing Altered Vaccine Immunogenicity and Low Vaccination Rates in Those With Autoimmune Diseases

Despite decades of research on the disproportionate impact of infection on those with rheumatic disease, patients in this population are less likely than those without rheumatic disease to undergo routine vaccination.

Missing Clinic Visit, Treatment Type, and Other Factors Influence TB Treatment Compliance

Missing Clinic Visit, Treatment Type, and Other Factors Influence TB Treatment Compliance

About 22% of 6232 patients did not complete latent tuberculosis (LTBI) treatment.

Should You Stay at Home When Sick? Evolution May Hold Answer

Should You Stay at Home When Sick? Evolution May Hold Answer

Symptoms of being sick are not an adaptation that works at the individual level, but are on the level of the "selfish gene," proposed researchers from the Weizmann Institute of Science.

Research Into TB Medications Strong, But Much More Work to Do

Research Into TB Medications Strong, But Much More Work to Do

Review outlines current treatment hurdles for TB.

Influenza Vaccine Remains A Vital Tool

Influenza Vaccine Remains A Vital Tool

Even if the flu shot "misses," as it did last year, it remains one of the best tools we have to help our patients live healthier lives.

Opioid Adjustment May Be Warranted During Peak Respiratory Illness Season

Opioid Adjustment May Be Warranted During Peak Respiratory Illness Season

A patient with debilitating chronic pain experiences an altered level of consciousness following a bout of the flu. Could his high-dose opioid regimen be to blame?

Combating Diabetes, Tuberculosis Epidemics Around the World

Combating Diabetes, Tuberculosis Epidemics Around the World

Greater efforts are needed to address the growing burden of tuberculosis and diabetes in developing countries.

Updated Sinusitis Guideline Released

Updated Sinusitis Guideline Released

The American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) has released updated clinical practice guidelines that highlight areas for improvement and recommendations for clinicians in managing adult sinusitis.

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