Respiratory Latest News Archive
New data suggest commensal respiratory microbiota play a significant role in susceptibility to viral infection.
High serum levels of IL-8 were highly specific and showed high sensitivity when combined with either the BALF, LFD, or BALF Aspergillus PCR, for differentiating probable invasive aspergillosis from cases with no infection.
Human airway mucus alters the susceptibility of Pseudomonas aeruginosa biofilms to tobramycin, but not colistin.
New research supports expanded restrictions on opioid-containing cough and cold medications for children.
Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) deaths in children decreased between 2000 and 2015.
Most deaths related to community-acquired pneumonia that occurred at tertiary-case hospitals were not preventable.
The CDC has issued updated recommendations regarding the use of 3HP for the treatment of latent tuberculosis.
Respiratory pathogens were associated with an increased risk for treatment failure in children with asthma exacerbations.
Baloxavir marboxil, an investigational, oral treatment for acute uncomplicated influenza in those aged ≥12 years has been granted Priority Review by the FDA.
There was an increase in Legionnaires' Disease (LD) from 2014 to 2016.
A national survey was conducted to assess influenza prevention practices in Veterans Affairs and non-Veterans Affairs hospitals in the United States.
Between 2014 and 2016, a total of 2967 cases of enterovirus and parechovirus were reported to the National Enterovirus Surveillance System in the United States.
Injection drug users are more than 16-fold more likely to develop invasive methicillin-resistant Staphylococcus aureus infections.
The real-world effectiveness of PCV13 vaccine in preventing hospitalization for vaccine-type community-acquired pneumonia was assessed.
Respiratory pathogens are associated with increased risk of treatment failure in children with asthma exacerbations.
The FDA has issued final guidance to assist in the development of drugs for the prevention of inhalational anthrax.
Infants with bronchiolitis and comorbidities plus other predictive factors are at higher risk for death following discharge from the emergency department.
Early clinical response rates were similar across PORT risk class subgroups in patients with community-acquired bacterial pneumonia when treated with omadacycline or moxifloxacin.
Clinicians should consider these findings when using atypical antipsychotics in patients at risk for pneumonia.
Study identifies and validates a simple PCR-based test from accessible blood samples that predicts TB in heterogeneous African populations with intermediate to high TB burdens.
Two novel immune-response clusters have been identified to respiratory syncytial virus, tied to first-, second-year recurrent wheeze.
In the LEAP 2 study (N=738), patients with moderate CABP received either oral lefamulin 600mg every 12 hours for 5 days or oral moxifloxacin 400mg once daily for 7 days.
A childhood measles infection may increase the risk for post-bronchodilator airflow obstruction in middle-age adults via its interaction with asthma and smoking.
Short-term exposure to fine particulate matter is associated with increased health care utilization for acute lower respiratory infection.
Large cavitary lung disease may increase cough frequency that lasts for a longer duration in individuals with tuberculosis.
Control of active tuberculosis (TB) and a major effort to decrease latent TB infection are both necessary to reduce morbidity and achieve TB elimination in the United States.
Additional studies are needed to investigate whether there are differences between individual fluoroquinolones with respect to the risk for aortic aneurysm.
During the cold and flu season, the use and over-dosing of paracetamol is common, and may partially be driven by higher use of over-the-counter combination medications for the treatment of upper respiratory cold/flu symptoms.
Researchers found increased myocardial infarction rates during the week after Streptococcus pneumoniae and influenza infections.
Researchers assessed the relationship between prevention of RSV in preterm infants and the frequency of subsequent wheeze in childhood.
When antibiotics are indicated for the treatment of acute bacterial sinusitis, the Infectious Diseases Society of America evidence-based clinical practice guidelines recommend 5 to 7 days of therapy for patients with a low risk of antibiotic resistance who have a favorable response to initial therapy.
Childhood measles compounds the association between smoking and midlife airflow obstruction.
The probability of direct transmission of respiratory diseases for passengers on transcontinental US flights not seated in close proximity to an infectious passenger is low.
Children receiving 3 months of once-weekly isoniazid and rifapentine were more likely to complete therapy than those receiving 9 months of daily isoniazid.
All formulations of a respiratory syncytial virus (RSV) candidate vaccine were able to boost RSV antibody titers and their safety profile was similar to the Tdap vaccine.
Patients with type 2 diabetes treated with sulfonylureas may be at a higher risk of contracting tuberculosis.
A simple diagnostic test aids in the early and accurate detection of respiratory viral infection.
Report updated the 2006 American College of Chest Physicians clinical practice guideline for cough due to TB and other chronic infections.
Broad-spectrum antibiotics are not associated with better clinical or patient-centered outcomes compared with narrow-spectrum antibiotics in pediatric acute RTI.
Prolonged treatment with high-dose steroids is a significant risk factor for pneumocystis pneumonia in patients with hematologic malignancies, solid organ transplants, and rheumatic diseases.
Prophylactic antibiotics delivered by nebulization in patients who were mechanically ventilated reduced the rate of ventilator-associated pneumonia
The iAdhere study found that once-weekly self-administration of isoniazid and rifapentine had high treatment completion rates in the United States, Hong Kong, Spain, and South Africa.
Additional strategies to prevent transmission will be necessary to stop multidrug-resistant (MDR) or extensively drug-resistant tuberculosis in countries with a high burden of MDR tuberculosis.
New data shows a higher risk of respiratory syncytial virus hospitalization for preterm infants during the 2015-2016 season vs data from the previous season.
Researchers assess all-cause mortality during tuberculosis treatment in patients with diabetes, the use of metformin, and effect sputum culture-conversion rates.
This new risk score may guide the identification of high-risk people who would benefit from preventative measures.
Difficulty breathing and hypoxemia may be a better indication of pneumonia in children.
High-dose vitamin D supplements do not prevent viral upper respiratory tract infections in young children.
Lower microbial diversity in the respiratory tract was linked with prophylactic antibiotic use and less airway inflammation in cystic fibrosis.
Regeneron discontinued further development of suptavumab for respiratory syncytial virus.
A new study examined whether isoniazid resistance was associated with variations in treatment outcomes in patients receiving standard first-line pharmacotherapy for TB.
A 'wait-and-see' approach may reduce the number of inappropriate antibiotic prescriptions for acute upper respiratory tract infections.
A change of QuantiFERON-TB interferon (IFN)γ values could improve tuberculosis detection.
A recent update of a meta-analysis evaluating treatments for latent tuberculosis infection found that several regimens, including those with a low pill burden and short duration, were safe and effective.
Varicella-zoster virus-related community-acquired pneumonia can be linked to significant rates of morbidity and mortality in adults.
High-doses of atorvastatin reduced inflammation and improved health-related quality of life in patients with bronchiectasis.
Patients admitted to high-volume intensive care units with acute respiratory distress syndrome were likely to experience a shorter hospital stay and lower mortality rate.
A decrease in all-cause mortality associated with multidrug-resistant tuberculosis (TB) can be correlated with an increase in directly observed therapy.
Retrospective study analyzes whether preadmission oral corticosteroids might lower ARDS risk in patients admitted to the ICU.
Oxidative stress after viral acute respiratory infections in the first year of life may increase the risk of recurrent wheezing in early childhood.
Risk of acute myocardial infarction is 17 times higher after respiratory infection.
Elderly patients with a nonbacterial acute upper respiratory tract infection are more likely to be prescribed antibiotics.
An increased risk in sepsis was linked to short-term oral corticosteroid use.
Evidence shows that antibiotic use before age 3 years is associated with asthma risk but not with asthma exacerbations in later childhood.
Deep learning with deep convolutional neural networks can accurately detect tuberculosis on chest radiographs.
Patients with a history of tuberculosis are at risk for developing osteoporosis or osteoporotic fractures.
Maternal vaccination of tetanus-diphtheria-acellular pertussis (Tdap) was found to be more effective in the second rather than the third trimester of pregnancy.
Maternal Tdap vaccination was found to be highly protective against pertussis in newborns.
The first RCT of high-flow warm humidified oxygen (HFWHO) compared to low-flow cold cannula oxygen showed HFWHO was safe and more effective when used after failed standard therapy.
Interrupting the transmission of extensively drug-resistant tuberculosis is the most important factor in curtailing the epidemic areas of high disease burden.
At this time, no vaccine to prevent or drug to treat respiratory syncytial virus infection is available.
First study to examine the benefit of treating GERD with proton pump inhibitors in reducing the acute respiratory infections complications.
Test uses procalcitonin as a biomarker to help make antibiotic management decisions in patients with lower respiratory tract infections and sepsis.
Vitamin D supplementation may prevent acute respiratory tract infections, according to a recent study.
A prospective, multicenter, randomized, placebo-controlled trial evaluates efficacy of the 23-valent pneumococcal polysaccharide vaccine in preventing pneumonia in patients with rheumatoid arthritis.
According to a new 7-year observational study, use of nonsteroidal anti-inflammatory drugs (NSAIDs) during acute respiratory infection may significantly increase the risk of heart attack.
Literature review and meta-analysis reveal poor treatment outcomes in patients with isoniazid-resistant TB.
High-dose vitamin D supplementation reduced the incident of acute respiratory infection in older long-term care residents.
Two phase 3 trials (ORBIT-3 and ORBIT-4) yielded promising results for Pulmaquin (inhaled ciprofloxacin) in treating patients with non-CF bronchiectasis who have chronic lung infections with P aeruginosa.
More awareness needed regarding the increasing burden of COPD in women.
Patients with acute bacterial lower respiratory tract infection have a slightly worse disease course than those without an identified bacterial cause.
A new study finds that COPD Assessment Test is a predictor of outcome among patients with interstitial lung disease.
Researchers find that oxygen therapy does not help patients in the less severe stages of COPD.
A five-item questionnaire plus peak expiratory flow can identify undiagnosed chronic obstructive pulmonary disease.
Pyrazinamide resistance linked with rifampicin resistance in treating TB, however, fourth generation fluoroquinolones are still highly effective.
Researchers predict COPD cases to increase by more than 150% from 2010 to 2030, with the greatest increase among those aged 75 years and older.
Probiotics does not reduce antibiotic use in patients with asthma.
Older adults are at significant risk for poor outcomes from pneumonia.
Stool samples from a racially diverse group of infants were used to map the bacterial and fungal gut environment.
The researchers noted that 68% of the errors made involved overdosing.
The statement defines some of those people who may be at risk for latent tuberculosis infection (LTBI), including people who have lived in group settings where TB exposure is likely, or those people who resided or were born in countries with a high prevalence of TB.
Despite fewer symptoms than diagnosed patients, they use similar health services for exacerbations.
Cases of endogenous Klebsiella pneumoniae endophthalmitis (EPKE) are on the rise in Australia.
The presence of viral RNA in blood is an indicator of more serious illness in patients with Middle East Respiratory Syndrome coronavirus, including fever, the need for mechanical ventilation, and death.
Higher risk of death from respiratory diseases, gastrointestinal diseases, and trauma.
Costs 1.62 times those of children with healthy weight.
Germs can survive on plastic surfaces for 24 hours or more.
Reduced antibiotic prescribing may lead to increase in pneumonia, peritonsillar abscess cases.
No significant effect for handgrip, handheld dynamometer strength, physical/mental health.
Researchers traced an outbreak of MERS-CoV to a single super-spreader patient at Samsung Medical Center in Seoul.
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