Variable Period of Risk for Myocardial Infarction and Stroke Following Sepsis
The results showed a time-varying risk profile of MI and stroke after sepsis in a Taiwanese population.
Patients recovering from sepsis had an elevated risk for myocardial infarction (MI) or stroke in the first 4 weeks after hospital discharge compared to the general population, according to data published in the Canadian Medical Association Journal.
Using a retrospective population-based cohort study, 42,316 patients with sepsis were identified from the National Health Insurance Research Database in Taiwan. The risk for MI and stroke following sepsis was assessed by comparing data from individuals who had sepsis to individuals of a matched population and hospital control group.
Because MI and stroke are independent risk factors for infection, only incident MI and stroke that occurred after the patient was discharged from the hospital admission index for sepsis were investigated to minimize protopathic bias. It is possible, however, that this underestimated the risk for MI and stroke after sepsis that developed during the index hospital admission. Detailed in-hospital parameters and laboratory results were also not available because of the use of administrative databases, resulting in investigators being unable to assess classification of patients into different severity scoring systems, which affects the risk for MI and stroke. Further, lifestyle factors and stroke subtypes could not be analyzed, also because of the use of administrative databases, but alcohol, smoking, or obesity-related diseases were used as a proxy for lifestyle factors.
Lai CC, Lee MG, Lee WC, et al. Susceptible period for cardiovascular complications in patients recovering from sepsis. CMAJ. 2018;190:E1062-E1069